EFFECTIVENESS OF PREGABALIN AND ORAL TRAMADOL AS PREVENTIVE ANALGESICS FOR POST-OPERATIVE DISCOMFORT IN PATIENTS UNDERGOING BREAST SURGERY
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Keywords
Pain relievers, Breast surgery, pregabalin and tramadol
Abstract
OBJECTIVE: To evaluate the effectiveness of pregabalin and tramadol as preventative analgesics in association with need of opioids during and after breast surgery.
BACKGROUND: Although prophylactic analgesia is not a new idea, in recent years it has become much more widely acknowledged in the treatment of both acute and chronic pain. Because breast cancer surgery is one of the procedures linked to a higher prevalence of chronic post-surgical pain, optimal pain management is even more crucial. Many techniques are employed, such as the use of local anesthetics and intravenous analgesics, to lessen the discomfort.
STUDY DESIGN: randomized control trial
PLACE AND DURATION: This study was conducted in Ghulam Muhammad Mahar Medical College, Sukkur from January 2023 to January 2024
METHADOLOGY: The breast cancer patients between the ages of 18 and 65 were included. Patients were divided into two groups: those in the experimental group took 50 mg of tab tramadol and 100 milligrams of pregabalin orally, while those in the placebo group took two soda mint pills orally half an hour earlier. The data analysis tool used was SPSS version 26
RESULTS: The mean age in group A was 42.34 ± 5.6, while 44.75 ± 8.34 in group B. The mean BMI was 29.62± 3.67 and 27.91 ± 4.12 in group A and B respectively. The morphine utilized in both groups did not differ substantially, while the mean rescue morphine was 0.43 ± 1.1 and 01.12 ± 0.98 in A and B groups (P –value= 0.076). The VAS score was significantly different in both groups.
CONCLUSION: The study concluded that pregabalin and tramadol are a better choice as preventative analgesics during and after breast surgery to minimize the need for pain relievers.
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Maqsood Ahmed Siddiqui
Associate Professor & Head Department of Anaesthesiology, SICU & Pain Management, Ghulam Muhammad Mahar Medical College, Sukkur Pakistan.
Pardeep Kumar
Resident FCPS 2 Anesthesiology, Liaquat University of Medical and Health Sciences Jamshoro Pakistan
Ahmed uddin Soomro
Associate Professor Anesthesiology, CMC Hospital @ SMBBMU Larkana Pakistan.
Kelash Kumar
Assistant Professor Anesthesiology and intensive care, Liaquat University of Medical and Health Sciences Jamshoro Pakistan
Muhammad Anwaar-ul-Hassan Khan
Consultant Anesthesiologist, D.H.Q Hospital Mianwali Pakistan
Mamoona Shaikh
Assistant Professor Anesthesiology, Liaquat University of Medical and Health Sciences Jamshoro Pakistan