OPTIMIZING VACCINE EFFICACY WITH DNA NANOSTRUCTURES: A COMPREHENSIVE REVIEW
Main Article Content
Keywords
DNA Nanostructures, Subunit Vaccines,, Immunogenicity Enhancement,, Nanotechnology-Based Delivery Systems, Systematic Review
Abstract
Background: This systematic review aims to evaluate the impact of DNA nanostructures on enhancing the immunogenicity of subunit vaccinations. It explores the literature to identify key aspects of utilizing DNA nanotechnology in vaccine design and administration, as well as strategies to optimize DNA-based subunit vaccines and address practical limitations.
Methods: A systematic literature search was conducted across multiple databases including PubMed, Scopus, Google Scholar, and Science Direct. Search terms encompassed descriptors related to DNA nanostructures and vaccine enhancement. Publications within the past decade, with full reports involving human subjects, were primarily considered. Eligibility was assessed based on predefined criteria, and included studies underwent rigorous bias assessment to ensure reliability.
Results: The review comprised 1,354 entries across all databases, with 10 studies meeting inclusion criteria. These studies were thoroughly analyzed to extract pertinent information on objectives, methodologies, results, and conclusions. Main findings highlight DNA nanostructures' capacity to serve as carriers, augmenting the immunogenic potential of subunit vaccines. Additionally, studies underscored the promise of nanodelivery systems in overcoming delivery barriers and maximizing DNA vaccine efficacy.
Discussion: This systematic review provides valuable insights into the potential applications, challenges, and future prospects of leveraging DNA nanostructures to enhance vaccines. By bridging basic science with clinical translation, it contributes to combating infectious and cancerous diseases and illuminates novel immunotherapeutic avenues. Further collaborative studies and developments are essential for deeper understanding of how DNA nanostructures enhance immunogenicity and for optimizing their application in vaccine development to bolster global public health.
Conclusion: The findings underscore the importance of advancing research and development efforts in harnessing DNA nanostructures for vaccine enhancement. Promoting optimization of DNA nanostructure utilization in vaccine design holds significant promise for positively impacting global public health outcomes.
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Faisal Saeed Alzahrni
Final Year MBBS Student, HBS Medical and Dental College Islamabad, Pakistan
Amina Farrukh Alavi
PhD Scholar, Department of Microbiology, Quaid-i-Azam University, Islamabad, Pakistan
Mohit Lakkimsetti
MBBS, Department of Internal Medicine, Mamata Medical College, Khammam, India
Ahmed Samir Abdelmageed Mohamed Elfiki
Internal Medicine Specialist and Resident in Egyptian Board 3rd Year, Egypt
Amgad Samir Abdelmageed Mohamed Elfeki
Internal Medicine Resident in Egyptian Board 3rd Year, Egypt
Likowsky Desir
MPH, MSc, Department of Surgery, Wyckoff Heights Medical Center, United States