THE CORRELATION BETWEEN POLYCYSTIC OVARY SYNDROME AND VITAMIN D DEFICIENCY: UNVEILING THE IMPACT OF LOW VITAMIN D LEVELS ON POLYCYSTIC OVARY SYNDROME SYMPTOMS
Main Article Content
Keywords
Vitamin D deficiency, Polycystic Ovary Syndrome, Hyperandrogenism, Insulin resistance, Menstrual irregularities
Abstract
Polycystic ovary syndrome (PCOS) is a prevalent hormonal disorder affecting 5-10% of women of reproductive age. Recent investigations highlight a potential link between PCOS and inflammation, with studies indicating elevated levels of inflammatory markers in women with PCOS compared to controls. This study involved 200 PCOS participants for investigation of impact of vitamin D with respect to clinical and metabolic traits and findings revealed that 60% of participants were vitamin D deficient (below 20 ng/mL). Deficiency was associated with higher rates of obesity (41.7% vs. 27.5%), oligo/amenorrhea (88.3% vs. 57.5%), and hirsutism (51.7% vs. 35%). Significant negative connections were observed between vitamin D levels and BMI, insulin resistance, androgen levels, hirsutism index, anovulatory cycles, and ovarian changes.
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20. Lagowska, K., Y. H., Snackey, C., Louwers, Y., Lips, P.(2018). "Vitamin D status and its association with metabolic risk markers, androgenic symptoms and ovarian volume in young females with different phenotypes of polycystic ovary syndrome." Hormone and Metabolic Research, 50(3), 220-226.
21. Teede, H. J., Adali, E., Kolusari, A., Edirne, T., Sahin, (2010). "Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan." BMC Medicine, 8, 41.
22. 9. Muscogiuri, G., Coraluzzi, L., Kustanovich, M., (2014). "Vitamin D and the metabolic syndrome." Reviews in Endocrine and Metabolic Disorders, 15(2), 135-146.
23. Pal, L., et al. (2016). "Vitamin D status relates to reproductive outcome in females with polycystic ovary syndrome: Secondary analysis of a randomized controlled trial." Journal of Clinical Endocrinology & Metabolism, 101(8), 3027-3035.
24. Pal, L., Berry, A., Coraluzzi, L., Kustanovich, M., Shpeen, B., & Isaacson, K. (2012). Therapeutic implications of vitamin D and insulin resistance in polycystic ovary syndrome. Gynecological Endocrinology, 28(3), 179-183. https://doi.org/10.3109/09513590.2011.589925
25. Thomson, R. L., Spedding, S., & Buckley, J. D. (2012). Vitamin D in the etiology and management of polycystic ovary syndrome. Clinical Endocrinology, 77(3), 343-350. https://doi.org/10.1111/j.1365-2265.2012.04434.x
26. Yildizhan, R., Kurdoglu, M., Adali, E., Kolusari, A., Edirne, T., Sahin, H. G., ... & Kamaci, M. (2009). Serum 25-hydroxyvitamin D concentrations in obese and non-obese females with polycystic ovary syndrome. Archives of Gynecology and Obstetrics, 280(4), 559-563. https://doi.org/10.1007/s00404-009-0966-y
2. Azziz, R., Carmina, E., Chen, Z., Dunaif, A., Laven, J. S., Legro, R. S., & Lizneva, D. (2016). Polycystic ovary syndrome. Nature Reviews Disease Primers, 2(1), 1-18. https://doi.org/10.1038/nrdp.2016.57
3. Bikle, D. D. (2014). Vitamin D metabolism, mechanism of action, and clinical applications. Chemistry & Biology, 21(3), 319-329. https://doi.org/10.1016/j.chembiol.2013.12.016
4. Dunaif, A. (2016). Perspectives in polycystic ovary syndrome: From hair to eternity. The Journal of Clinical Endocrinology & Metabolism, 101(3), 759-768. https://doi.org/10.1210/jc.2015-3900
5. Escobar-Morreale, H. F. (2018). Polycystic ovary syndrome: Definition, etiology, diagnosis, and treatment. Nature Reviews Endocrinology, 14(5), 270-284. https://doi.org/10.1038/nrendo.2018.24
6. Irani, M., & Merhi, Z. (2014). Role of vitamin D in ovarian physiology and its implication in reproduction: A systematic review. Fertility and Sterility, 102(2), 460-468. https://doi.org/10.1016/j.fertnstert.2014.04.046
7. Javed, Z., Papageorgiou, M., Deshmukh, H., Kilpatrick, E. S., Mann, V., Corless, L., ... & Atkin, S. L. (2019). Vitamin D3 supplementation in polycystic ovary syndrome: A double-blind randomized placebo-controlled trial. Journal of Clinical Endocrinology & Metabolism, 104(4), 1119-1131. https://doi.org/10.1210/jc.2018-01192
8. Krul-Poel, Y. H., Snackey, C., Louwers, Y., Lips, P., Lambalk, C. B., Laven, J. S., ... & Simsek, S. (2018). The role of vitamin D in metabolic disturbances in polycystic ovary syndrome: A systematic review. European Journal of Endocrinology, 179(5), 67-76. https://doi.org/10.1530/EJE-18-0364
9. Muscogiuri, G., Policola, C., Prioletta, A., Sorice, G. P., Mezza, T., Lassandro, A., ... & Bizzarri, C. (2014). Low levels of 25(OH)D and insulin resistance: 2 unrelated features or a cause-effect in POLYCYSTIC OVARY SYNDROME? Clinical Nutrition, 33(4), 676-680. https://doi.org/10.1016/j.clnu.2013.09.009
10. Pal, L., Berry, A., Coraluzzi, L., Kustanovich, M., & Shmulsky, A. (2012). Therapeutic implications of vitamin D and calcium in overweight females with polycystic ovary syndrome. Gynecological Endocrinology, 28(12), 965-968. https://doi.org/10.3109/09513590.2012.696753
11. Pittas, A. G., Lau, J., Hu, F. B., & Dawson-Hughes, B. (2007). The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. The Journal of Clinical Endocrinology & Metabolism, 92(6), 2017-2029. https://doi.org/10.1210/jc.2007-029
12. Rashidi, B., Haghollahi, F., Shariat, M., & Zayerii, F. (2009). The effects of calcium-vitamin D and metformin on polycystic ovary syndrome: A pilot study. Taiwanese Journal of Obstetrics and Gynecology, 48(2), 142-147. https://doi.org/10.1016/S1028-4559(09)60274-9
13. Teede, H. J., Misso, M. L., Costello, M. F., Dokras, A., Laven, J., Moran, L., ... & International Polycystic ovary syndrome Network. (2018). Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome. Human Reproduction, 33(9), 1602-1618. https://doi.org/10.1093/humrep/dey256
14. Thomson, R. L., Spedding, S., & Buckley, J. D. (2012). Vitamin D in the etiology and management of polycystic ovary syndrome. Clinical Endocrinology, 77(3), 343-350. https://doi.org/10.1111/j.1365-2265.2012.04355.x
15. Wehr, E., Pilz, S., Schweighofer, N., Giuliani, A., Kopera, D., Pieber, T. R., ... & Obermayer-Pietsch, B. (2011). Association of hypovitaminosis D with metabolic disturbances in polycystic ovary syndrome. European Journal of Endocrinology, 164(4), 575-582. https://doi.org/10.1530/EJE-10-1045
16. Yildizhan, R., Kurdoglu, M., Adali, E., Kolusari, A., Edirne, T., Sahin, H. G., ... & Kamaci, M. (2009). Serum 25-hydroxyvitamin D concentrations in obese and non-obese females with polycystic ovary syndrome. Archives of Gynecology and Obstetrics, 280(4), 559-563. https://doi.org/10.1007/s00404-009-0953-1
17. Contreras-Bolívar, V., García-Fontana, B., García-Fontana, C., & Muñoz-Torres, M. (2021) Mechanisms Involved in the Relationship between Vitamin D and Insulin Resistance: Impact on Clinical Practice. Nutrients, 13(10), 3491. https://doi.org/10.3390/nu13103491
18. Saharkhiz, P. (2021b, January 11). Dealing with POLYCYSTIC OVARY SYNDROME: Symptoms, Side Effects, and Treatments. Elan Healthcare. https://elanhealthcare.ca/blogs/health-blog/a-review-of-polycystic-ovarian-syndrome-Polycystic ovary syndrome
19. Várbíró, S., Takács, I., Tűű, L., Nas, K., Sziva, R. E., Hetthéssy, J. R., & Török, M. (2022). Effects of Vitamin D on Fertility, Pregnancy and Polycystic Ovary Syndrome—A Review. Nutrients, 14(8), 1649. https://doi.org/10.3390/nu14081649
20. Lagowska, K., Y. H., Snackey, C., Louwers, Y., Lips, P.(2018). "Vitamin D status and its association with metabolic risk markers, androgenic symptoms and ovarian volume in young females with different phenotypes of polycystic ovary syndrome." Hormone and Metabolic Research, 50(3), 220-226.
21. Teede, H. J., Adali, E., Kolusari, A., Edirne, T., Sahin, (2010). "Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan." BMC Medicine, 8, 41.
22. 9. Muscogiuri, G., Coraluzzi, L., Kustanovich, M., (2014). "Vitamin D and the metabolic syndrome." Reviews in Endocrine and Metabolic Disorders, 15(2), 135-146.
23. Pal, L., et al. (2016). "Vitamin D status relates to reproductive outcome in females with polycystic ovary syndrome: Secondary analysis of a randomized controlled trial." Journal of Clinical Endocrinology & Metabolism, 101(8), 3027-3035.
24. Pal, L., Berry, A., Coraluzzi, L., Kustanovich, M., Shpeen, B., & Isaacson, K. (2012). Therapeutic implications of vitamin D and insulin resistance in polycystic ovary syndrome. Gynecological Endocrinology, 28(3), 179-183. https://doi.org/10.3109/09513590.2011.589925
25. Thomson, R. L., Spedding, S., & Buckley, J. D. (2012). Vitamin D in the etiology and management of polycystic ovary syndrome. Clinical Endocrinology, 77(3), 343-350. https://doi.org/10.1111/j.1365-2265.2012.04434.x
26. Yildizhan, R., Kurdoglu, M., Adali, E., Kolusari, A., Edirne, T., Sahin, H. G., ... & Kamaci, M. (2009). Serum 25-hydroxyvitamin D concentrations in obese and non-obese females with polycystic ovary syndrome. Archives of Gynecology and Obstetrics, 280(4), 559-563. https://doi.org/10.1007/s00404-009-0966-y
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Jun 18, 2024
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How to Cite
Dr Shweta Mendiratta, & Dr Preeti Singh. (2024). THE CORRELATION BETWEEN POLYCYSTIC OVARY SYNDROME AND VITAMIN D DEFICIENCY: UNVEILING THE IMPACT OF LOW VITAMIN D LEVELS ON POLYCYSTIC OVARY SYNDROME SYMPTOMS. Journal of Population Therapeutics and Clinical Pharmacology, 31(6), 1301-1309. https://doi.org/10.53555/jptcp.v31i6.6669
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Author Biographies
Dr Shweta Mendiratta
Senior Consultant, Assistant Professor, Amrita Institute of Medical Sciences, Faridabad
Dr Preeti Singh
Dr Preeti Singh, MBBS DNB, Assistant professor, Amrita School of Medicine Faridabad
How to Cite
Dr Shweta Mendiratta, & Dr Preeti Singh. (2024). THE CORRELATION BETWEEN POLYCYSTIC OVARY SYNDROME AND VITAMIN D DEFICIENCY: UNVEILING THE IMPACT OF LOW VITAMIN D LEVELS ON POLYCYSTIC OVARY SYNDROME SYMPTOMS. Journal of Population Therapeutics and Clinical Pharmacology, 31(6), 1301-1309. https://doi.org/10.53555/jptcp.v31i6.6669