PREPARATION AND IN VITRO EVALUATION OF IMMEDIATE-RELEASE TABLETS OF EMTRICITABINE
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Keywords
Emtricitabine, Sodium starch glycolate, Polyplasdone XL10, Ac-Di-Sol, Immediate-release tablets.
Abstract
Immediate-release tablets disintegrate rapidly in the gastrointestinal tract, ensuring swift drug release and absorption. Recently, these tablets have gained popularity and acceptance as a drug delivery system due to their ease of administration and enhanced patient compliance. This study aims to formulate and evaluate various direct compression immediate-release tablets of Emtricitabine using different superdisintegrants (Sodium starch glycolate, Polyplasdone XL10, and Ac-Di-Sol). Fourier-transform infrared spectroscopy (FTIR) was employed to investigate the interactions between the drug and excipients. Emtricitabine granules and tablets were subjected to various pre- and post-compression assessments, including angle of repose, compressibility index, Hausner's ratio, tablet hardness, friability, and in vitro disintegration and dissolution tests. The results were satisfactory across all parameters. Among the formulations, the F3 procedure demonstrated the highest in vitro dissolution profile, suggesting that it is the most effective formulation for immediate drug release.
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Shaik Neha Samreen
Research scholar Department of Pharmaceutics, Safa College of Pharmacy, Kurnool
B Sandhya Rani
Assistant Professor, Safa College of Pharmacy, Kurnool
K. Lakshmikanth
Research scholar Department of Pharmaceutics, Safa College of Pharmacy, Kurnool
M. Priyanka
Research scholar Department of Pharmaceutics, Safa College of Pharmacy, Kurnool
MD Iftekhar Ahmed Khan
Associate Professor, Department of Pharmaceutics, Safa College of Pharmacy, Kurnool
MISBA
Assistant Professor, Safa College of Pharmacy, Kurnool
Dr. Md Sultan Ali Basha
Professor and Principal, Safa College of Pharmacy, Kurnool