COMPUTERIZED IDENTIFICATION OF THE PHASES OF LIVER FIBROSIS BY ULTRASONOGRAPHY: QUANTITATIVE STUDY OF DEEP CONVOLUTIONAL NEURAL NETWORK

Main Article Content

Shekh Mohammad Mostafa
Sejuti Sarker Tinny
Meshari Attar
Sandra Rumi Madhu
Kamrun Nahar
Md. Allama Iqbal
Rabia Zulfiqar

Keywords

computerized identification, phases, liver fibrosis, ultrasonography, deep convolutional neural network

Abstract

This study aimed to evaluate the effectiveness of a widely used and well-respected deep convolutional neural network and to determine the computerized detection of liver fibrosis episodes using ultrasonography. In three months of 2024, a quantitative study was conducted in several settings in Bangladesh. The design of the study was quantitative; therefore informed consent was not required. While non-invasive techniques like transient elastography are frequently employed to assess liver fibrosis, mistakes may arise in situations involving a constricted liver or ascites. In this work, we used US photos to fine-tune the model following transfer learning on ImageNet. In this study, the learning-rate scheduler and optimization algorithm was Adam optimizer, respectively, while the loss function used for training the models was CrossEntropyLoss. Accuracy, sensitivity, specificity, and positive and negative likelihood ratios were used to assess DCNN performance. Furthermore, the effectiveness of DCNNs was evaluated using the area under the receiver operating characteristic curve (AUC) with a 95% confidential interval for five-level categorization. 49 were the median age (IQR: 42–58). F0 is generally easy to get, and 33.2% of the dataset consists of such data. 33.2% of the dataset was made up of liver fibrosis stage 4, or F4. However, because so few individuals were evaluated in the early stages of hepatic fibrosis, the proportions of F1 (13.2%), F2 (8.4%), and F3 (24.2%) were quite low. Using a computer vision method, a data augmentation of the images expands the size of a limited dataset. In the final analysis, researchers have shown that DCNNs can accurately classify METAVIR grade employing traditional US pictures. The DCNNs-based diagnosis of liver fibrosis using B-mode images will be an effective instrument for promoting radiologists in the clinical setting, as US imaging is a commonly accessible method and is primarily employed in periodic subsequent studies of patients with persistent liver disease. Additional enhancement and verification might be necessary, though.

Abstract 181 | PDF Downloads 44

References

[1] Song, J., Zhang, Y., Cheng, J., Wang, S., Liu, Z., & Sun, D. (2022). Non-invasive quantitative diagnosis of liver fibrosis with an artificial neural network. Neural Computing and Applications, 1-12.
[2] Nguyen, T. N., Podkowa, A. S., Park, T. H., Miller, R. J., Do, M. N., & Oelze, M. L. (2021). Use of a convolutional neural network and quantitative ultrasound for diagnosis of fatty liver. Ultrasound in medicine & biology, 47(3), 556-568.
[3] Banik, S., Barai, N. G., & Shamrat, F. J. M. (2023). Blockchain Integrated Neural Networks: A New Frontier in MRI-based Brain Tumor Detection. Brain, 14(11).
[4] Destrempes, F., Gesnik, M., Chayer, B., Roy-Cardinal, M. H., Olivié, D., Giard, J. M., ... & Tang, A. (2022). Quantitative ultrasound, elastography, and machine learning for assessment of steatosis, inflammation, and fibrosis in chronic liver disease. PLoS One, 17(1), e0262291.
[5] Cha, D. I., Kang, T. W., Min, J. H., Joo, I., Sinn, D. H., Ha, S. Y., ... & Yi, J. (2021). Deep learning-based automated quantification of the hepatorenal index for evaluation of fatty liver by ultrasonography. Ultrasonography, 40(4), 565.
[6] Banik, S., Barai, N. G., & Shamrat, F. J. M. (2023). Blockchain Integrated Neural Networks: A New Frontier in MRI-based Brain Tumor Detection. Brain, 14(11).
[7] Li, B., Tai, D. I., Yan, K., Chen, Y. C., Chen, C. J., Huang, S. F., ... & Harrison, A. P. (2022). Accurate and generalizable quantitative scoring of liver steatosis from ultrasound images via scalable deep learning. World Journal of Gastroenterology, 28(22), 2494.
[8] Jeon, S. K., Lee, J. M., Joo, I., Yoon, J. H., & Lee, G. (2023). Two-dimensional convolutional neural network using quantitative US for noninvasive assessment of hepatic steatosis in NAFLD. Radiology, 307(1), e221510.
[9] Sohel Mahmud, Sharmin Ara Yasmin, Nahal Mostak Khan, Soheb Ahmed Robin & Lutfullahil Khabir (2024). Demographic Profile & Associated Risk Factors of Patients with Retinal Vein Occlusion in a Tertiary Eye Hospital. Dinkum Journal of Medical Innovations, 3(01):64-71.
[10] Surachhya Sharma (2024). Knowledge, Attitude and Practices of Hormonal Contraceptives and Incidences of ADR among Users. Dinkum Journal of Medical Innovations, 3(02):199-213.
[11] Dr. Shovit Dutta (2024). Knowledge & Practice about Personal Hygiene among Primary School Students in Rural Chattogram, Bangladesh . Dinkum Journal of Medical Innovations, 3(02):72-88.
[12] Dr. Anupama Sharma, Dr. Himanshu Shah & Dr. Vandana Mourya (2024). The evaluation of maternal morbidity and perinatal morbidity & mortality in Breech Delivery and Its Comparison with Mode of Delivery. Dinkum Journal of Medical Innovations, 3(02):89-101.
[13] Dr. Md. Hasan Moshiur Shawon & Prof. Dr. Shanjoy Kumar Paul (2024). Risk Factors of Urinary Tract Infection Caused by Extended-Spectrum Beta-Lactamases-Producing Bacteria in Children . Dinkum Journal of Medical Innovations, 3(02):102-117.
[14] Muhammad Abdullah Al Amin, Abdul Mumin, A.K.M Shahariar Kabir, Rifat Ara Noor, Md Atiqur Rahman, Urmi Rahman & Fatema Marzia Nur (2024). Role of Dexamethasone in the Management of Acute Ischaemic Stroke in a Tertiary Hospital: A Randomized Clinical Study . Dinkum Journal of Medical Innovations, 3(02):118-131.
[15] Dr. Nabin Kumar Sinjali Magar, Dr. Dhruba Gaire & Dr. Prasanna Bahadur Amatya (2024). Evaluation of Pulmonary Hypertension in Chronic Obstructive Pulmonary Disease (COPD) by assessment of Chest X- Ray, ECG and Echocardiography. Dinkum Journal of Medical Innovations, 3(02):132-144.
[16] Dr. Rosina Paudel, Dr. Dhan Keshar Khadka & Dr. Arpana Rijal (2024). Clinico-epidemiological Profile of Adult Acne and factors Associated with Adult Acne . Dinkum Journal of Medical Innovations, 3(02):145-164.
[17] Dr. Sangam Pokharel, Dr. Rajesh Yadav, Dr. Anima Pradhan & Dr. Ashmita Paudel (2024). Comparative Study of Bupivacaine 0.5% and Ropivacaine 0.75% Epidurally In Lower Limb Orthopedic Surgeries. Dinkum Journal of Medical Innovations, 3(02):165-173.
[18] Ms. Saroja Poudel & Dr. Rajesh Niraula (2024). Comprehensive study of Placenta Previa & Its Psychological Consequences. Dinkum Journal of Medical Innovations, 3(02):174-187.
[19] Dr. Sujan Pradhan, Dr. Sabi Rana, Dr. Property Bhandari, Dr. Ozone Shrestha & Dr. Pranjal Shrestha (2024). The Correlation of Hearing Loss with Site & Size in Tympanic Membrane Perforation. Dinkum Journal of Medical Innovations, 3(02):188-198.
[20] Abdul Mumin, Abdullah Al Amin, A.K.M. Shahriar Kabir, Rifat Ara Noor & Urmi Rahman (2024). Role of C- Reactive Protein (CRP) and Neutrophil Lymphocyte Ratio (NLR) in detecting severity & Predicting outcome of Acute Pancreatitis patients. Dinkum Journal of Medical Innovations, 3(01):01-12.
[21] Dr. Prabin Kumar Jha, Dr. Bindu Laxmi Shah, Dr. Shruti Kumari Thakur & Dr. Avinash Thakur (2024). Effectiveness of Dexamethasone as an Adjuvant to Bupivacaine in Supraclavicular Brachial Plexus Block. Dinkum Journal of Medical Innovations, 3(01):13-25.
[22] Nahal Mostak Khan, Soheb Ahmed Robin, Lutfullahil Khabir & Sohel Mahmud (2024). Role of Vitamin C in Development of Age Related Cataract. Dinkum Journal of Medical Innovations, 3(01):26-34.
[23] Nistha Thapa, Puja Gartaula & Pushpa Chand Thakuri (2024). Knowledge of hygienic food-handling Practices among street Food vendors in Dhading Besi, District Dhading, Nepal. Dinkum Journal of Medical Innovations, 3(01):35-51.
[24] Dr. Md. Salah Uddin (2024). Correlation between Duration of Preoperative Motor Deficit and Early Postoperative Motor Functional Recovery in Patients with Intradural Extramedullary Spinal Tumor. Dinkum Journal of Medical Innovations, 3(01):52-63
[25] Banik, S., Barai, N. G., & Shamrat, F. J. M. (2023). Blockchain Integrated Neural Networks: A New Frontier in MRI-based Brain Tumor Detection. Brain, 14(11).
[26] Cheng, G., Dai, M., Xiao, T., Fu, T., Han, H., Wang, Y., ... & Yu, J. (2021). Quantitative evaluation of liver fibrosis based on ultrasound radio frequency signals: An animal experimental study. Computer Methods and Programs in Biomedicine, 199, 105875.
[27] Mst.Dil Afroz Bhuiyan, Md. Abul Hossain, Shekh Mohammad Mostafa, Anirudha Biswas, Mohammed Samiullah, Gul Mehnaz, Fozan Ahmad, Arooj Saeed, Arif Ahmed, & Rabia Zulfiqar. (2024). The QUANTITATIVE ANALYSIS OF HAZARDS OF HEAVY METALS ON HUMAN HEALTH AND AGRICULTURAL PRODUCTION. Journal of Population Therapeutics and Clinical Pharmacology, 31(2), 2820–2829. https://doi.org/10.53555/jptcp.v31i2.4543.
[28] Azer, S. A. (2019). Deep learning with convolutional neural networks for identification of liver masses and hepatocellular carcinoma: A systematic review. World journal of gastrointestinal oncology, 11(12), 1218.
[29] Reddy, D. S., Bharath, R., & Rajalakshmi, P. (2018, September). A novel computer-aided diagnosis framework using deep learning for classification of fatty liver disease in ultrasound imaging. In 2018 IEEE 20th international conference on e-health networking, applications and services (Healthcom) (pp. 1-5). IEEE.
[30] Punn, N. S., Patel, B., & Banerjee, I. (2024). Liver fibrosis classification from ultrasound using machine learning: a systematic literature review. Abdominal Radiology, 49(1), 69-80.
[31] Lu, X. Z., Hu, H. T., Li, W., Deng, J. F., Cheng, M. Q., Huang, H., ... & Sun, B. G. (2024). Exploring hepatic fibrosis screening via deep learning analysis of tongue images. Journal of Traditional and Complementary Medicine.
[32] Zhang, Z., Li, G., Wang, Z., Xia, F., Zhao, N., Nie, H., ... & Liu, X. (2024). Deep-learning segmentation to select liver parenchyma for categorizing hepatic steatosis on multinational chest CT. Scientific Reports, 14(1), 11987.
[33] Santoro, S., Khalil, M., Abdallah, H., Farella, I., Noto, A., Dipalo, G. M., ... & Portincasa, P. (2024). Early and accurate diagnosis of steatotic liver by artificial intelligence (AI)-supported ultrasonography. European Journal of Internal Medicine.
[34] Banik, S., Barai, N. G., & Shamrat, F. J. M. (2023). Blockchain Integrated Neural Networks: A New Frontier in MRI-based Brain Tumor Detection. Brain, 14(11).

Most read articles by the same author(s)