The Role of Microbiota in Gastrointestinal Cancers: Investigating the Gut Microbiome's Influence on Tumor Development and Treatment Response
Main Article Content
Keywords
Gut microbiome, gastrointestinal cancers, tumor development, treatment response, microbiota profiles, biomarkers.
Abstract
Recent research has tinted significant role of gut microbiota in various physiological procedures, with its influence on gastrointestinal (GI) cancers. The interaction among gut microbiome and host's immune system, metabolic functions, and response to therapies in GI cancers necessitates a comprehensive understanding of these dynamics.
Aim: This research intended to investigate influence of gut microbiome on development and treatment response of gastrointestinal cancers.
Methods: A cohort of 90 patients diagnosed with various gastrointestinal cancers was enrolled for this study, conducted from March 2023 to February 2024. The study employed a longitudinal design, collecting fecal samples at multiple time points before, throughout, and after treatment. High-throughput sequencing was used to analyze microbiome composition. Clinical data, including tumor progression, treatment outcomes, and patient demographics, were integrated with microbiome profiles to assess correlations.
Results: The analysis revealed significant alterations in gut microbiota arrangement between patients with different stages of GI cancers and healthy controls. Specific microbial taxa were associated with tumor development and progression. Notably, patients who responded favorably to cancer treatments exhibited distinct microbiome signatures compared to non-responders. These findings suggested that certain microbiota profiles could predict treatment efficacy and patient prognosis.
Conclusion: The study demonstrated that gut microbiome plays very crucial part in development and progression of gastrointestinal cancers. Furthermore, microbiota profiles were linked to treatment response, indicating potential for microbiome-based biomarkers in predicting treatment outcomes. These insights underscore the importance of integrating microbiome analysis into cancer management strategies
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