AN INVESTIGATIVE MULTICENTRIC EVALUATION OF THE PSYCHOLOGICAL AND BEHAVIORAL SYMPTOMS THAT CORRESPOND TO DEMENTIA
Main Article Content
Keywords
Dementia, Behavioral and psychological symptoms, clusters, NPI-Q, MoCA, CDR, psychiatric disorder(s)
Abstract
Background: Dementia is typically predicted to result in behavioral and psychological symptoms (BPS). BPS has an impact on care expenditures, quality of life, and morbidity and burden. Less research has been done on the symptom features, clinical correlations, and symptom-specific clusters that help in diagnosis, particularly in the Indian population.
Materials and Methods: As part of a multicentric study conducted in India, the current study looked at the BPS clusters based on different cognitive and neuropsychiatric profiles in dementia patients. Using the Neuropsychiatric Inventory Questionnaire (NPI-Q), the Montreal Cognitive evaluation (MoCA) for cognitive functioning, and the Clinical Dementia Rating (CDR) scale for dementia severity, we conducted a cross-sectional evaluation. Furthermore, a standardized Clinical Interview for DSM-5 Research Version was used to assess each participant for previous psychiatric disorder(s).
Results: We outline the different BPS clusters that are specifically linked to dementia severity. Three symptom clusters (anxiety, irritability, abnormal motor) were predicted for mild dementia, two symptom clusters (disinhibition, agitation/aggression) for intermediate dementia, and three symptom clusters (delusion, euphoria/elation, disinhibition) for severe dementia based on linear regression analysis.
Conclusion: The research offers valuable understanding of the diverse symptom attributes and their correlations within BPS, potentially aiding clinicians in the evaluation of dementia patients.
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Jeby Abraham
Medical Officer / General Medicine Yenepoya Medical University, Deralakatte, Karnataka, India 575018
Ahmad Farqleet
Research Student Aziz Fatimah Medical and Dental College Faisalabad, Punjab, Pakistan
Tshetiz Dahal
General Physician, Clinical Researcher General Medicine Lugansk State Medical University, 16 Lypnia St. Rivne 33028, Ukraine
Dhiraj Prasad Shah
Medical Officer Kathmandu University, Dhulikhel, Kavre, Nepal 6250