CLINICAL STUDY OF DYNAMIC CHANGES OF ACUTE PHASE REACTANTS IN SEPSIS
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Keywords
Sepsis, biochemical abnormalities, infections
Abstract
Aim: - The aim of this original research is to evaluate APR levels in sepsis, evaluate procalcitonin's significance, analyze the predictive role of CRP and Procalcitonin, and examine the correlation of serum albumin levels with treatment outcomes.
Method: - The prospective observational study was conducted at a health care urban teaching hospital in Gujarat, India, between May 2019 and October 2020. The research included 105 ICU patients diagnosed with sepsis, meeting specific inclusion criteria such as age above 18 years and fulfilling the qSOFA score parameters. Patients with chronic inflammatory conditions, advanced malignancy, or who did not provide consent were excluded.
Result: - This study investigated biomarker trends and clinical outcomes in sepsis patients. The analysis included 105 ICU patients with sepsis. Results showed significant trends in erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels, while white blood cell (WBC) count and ferritin levels remained stable. Albumin levels were statistically significant. The distribution of scores revealed different levels of severity. Outcomes presented a discharge rate of 71.4% and a fatal outcome rate of 28.6%. This study provides valuable insights into biomarker dynamics and their correlation with sepsis outcomes.
Conclusion: - Acute Phase Reactants (APRs) provide valuable insights into sepsis. CRP is a strong predictor of prognosis, while procalcitonin indicates poor outcomes. Serum Albumin is useful for short-term outcome prediction. CRP and procalcitonin guide antibiotic treatments in sepsis.
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Dr. Rinal M Parikh
MBBS, MD General Medicine Senior Resident Department of General Medicine, Shri Narendra
Modi Medical College and LG Hospital, Ahmedabad
Dr. Anushree Paras Doshi
MBBS, MD General Medicine General Medicine Resident at Department of General Medicine from Narendra Modi Medical College, Ahmedabad
Dr. Utsav Rajeshbhai Thakkar
MBBS Intern Doctor at Smt. NHL Municipal Medical College and Sardar Vallabhbhai Patel Institute Of Medical Sciences And Research, Ahmedabad
Dr. Rishva Parthiv Vyas
MBBS Intern Doctor at Smt. NHL Municipal Medical College and Sardar Vallabhbhai Patel Institute Of Medical Sciences And Research, Ahmedabad
Dr. Juhi R Ramnani
MBBS, MD General Medicine Senior Resident at Department of General Medicine from Shri Narendra Modi Medical College and LG Hospital, Ahmedabad
Dr. Ishan Parthiv Vyas
MBBS Shri Narendra Modi Medical College and LG Hospital, Ahmedabad