INTRALESIONAL TRANEXAMIC ACID-EFFECTIVE AND SAFE WAY OF TREATMENT FOR MELASMA.
Main Article Content
Keywords
melasma, intralesional tranexamic acid, oral tranexamic acid, treatment of melasma.
Abstract
Even though melasma is primarily a cosmetic concern, this condition can dramatically impact the quality of life of affected patients and causes depression and frustration, reducing their psychosocial quality of life. Currently, there are numerous treatment modalities for melasma but it is a challenging condition for dermatologists due to its chronicity and with a high recurrence rate after treatment. However, for the satisfactory outcomes, role of the recent developments, tranexamic acid (TA) was evaluated. A quasi-experimental study was done to evaluate the efficacy and safety of tranexamic acid (TA). Group A Patients were administered intralesional injection (4 mg/ml) of Tranexamic acid (TA) weekly for 6 weeks and group B patients were treated with oral Tranexamic acid 250 mg 12 hourly for 12 weeks. The response to treatment was assessed by The Melasma Area and Severity Index (MASI) score. The study showed the MASI scores at the baseline, 4 weeks, 8 weeks and 12 weeks in group A were 15.23±1.21, 5.14±2.25, 3.11±1.14 and 2.21±2.01 respectively and in group B 14.77±1.11,10.21±4.25, 7.57±5.25 and 6.22±4.16 respectively. The mean MASI significantly reduced in group A compared to group B. The present study showed that among the group A patients, 44% rated excellent (>75% reduction) in outcome, and only 8%(<25% reduction) was unsatisfactory and among group B patients, 16% rated excellent in outcome, and 18% was unsatisfactory. Side effects were negligible. Study results concluded that intralesional injection of tranexamic acid produces effective results without significant side effects.
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Lubna Khondker
Associate Professor, Dept of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.
Md Shirajul Islam Khan
Professor (Brigadier General), Head of Dept of Dermatology and Venereology, Combined Military Hospital (CMH), Dhaka, Bangladesh.
Toioba Akter
Junior Consultant, Department of Dermatology and Venereology, Dhaka Medical College Hospital, Dhaka, Bangladesh.