AMELIORATION OF THROMBOCYTOPENIA AND COAGULATIVE PARAMETERS BY CARICA PAPAYA FRUIT WITH HEMATOLOGICAL AND HISTOPATHOLOGICAL EVIDENCE – AN IN-VIVO STUDY

Abstract

Introduction: Recent research on analyses of the platelet-boosting abilities of polyphenolic compounds and nutritional supplements, and their efficacy to impact health parameters has been established. C. papaya is renowned for its excellent digestive, antioxidant, and nutraceutical properties derived from bioactive substances such as papain, latex, carpaines, benzyl glucosinolates, choline, zeaxanthin, and more.

Material and Methods: Twenty-four rats were randomly divided into four groups, each consisting of six: NC & CPF₁ (normal control & negative control), CPF₂, and CPF₃ (300 & 600 mg/kg dried papaya fruit). The Wistar albino rats were exposed to thrombocytopenia by cyclophosphamide (s.c.). Blood samples were collected on days 0, 10, 20, and 30 to analyze the serum platelet count and coagulation profile. Following 30 days, the kidney and liver were dissected for histopathological evaluation.

Results: The Platelet count was significantly elevated (p≥0.05) compared to normal and negative control in experimental groups. The platelet count within the CPF₃ group (a dose of 600 mg CPF), showed more promising results as compared to the CPF₂ group (a dose of 300 mg CPF) while observed at 0, 10, 20, and 30th days. The histopathology analysis on the kidney and liver revealed a reversal toward normal parenchymal structure on an administered dose of 600 mg of C. papaya L. fruit.

Conclusion: C. papaya fruit provides promise for its potential application in treating and controlling thrombocytopenia and associated bleeding disorders. This effect may be attributed to carpaines, ascorbic acid, and carotenoids in C. papaya L.