MULTIDRUG-RESISTANT PATHOGENS IN WOUND INFECTIONS: FINDINGS FROM A TERTIARY CARE HOSPITAL IN PESHAWAR, PAKISTAN
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Abstract
The emergence and spread of multidrug-resistant pathogens in wound infections represent a growing public health concern, threatening to undermine the efficacy of conventional antimicrobial therapies. Objectives: The main objective of the study is to find the multidrug-resistant (MDR) pathogens in wound infections and these findings are from a tertiary care hospital in Peshawar, Pakistan. Methodology of the study: This retrospective observational study was conducted at Lady Reading Hospital Peshawar from January 2023 till December 2023. A total of 350 patients with clinically diagnosed wound infections were included in the study. Patients of all ages and genders who presented with wound infections during were included in the study. Patient data were retrieved from electronic medical records, including demographic information, clinical history, wound characteristics, microbiological culture results, and antibiotic susceptibility profiles. Results: Data were collected from 350 patients according to inclusion criteria. Out of the 350 patients included in the study, multidrug-resistant pathogens were identified in 45% of cases. The most commonly isolated multidrug-resistant organisms were Methicillin-resistant Staphylococcus aureus (MRSA) (20%), Extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli (15%), and Vancomycin-resistant Enterococcus (VRE) (10%). It revealed that patients with MDR infections had a significantly higher rate of prolonged hospital stays, with 70% requiring extended medical care compared to 40% in the susceptible group. Conclusion: It is concluded that wound infections caused by multidrug-resistant pathogens pose significant challenges in clinical practice, emphasizing the critical need for effective management strategies
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