EXAMINING CD133, C-MYC, AND AXL EXPRESSION IN COLON ADENOCARCINOMAS: PROGNOSTIC VALUE AND CLINICAL ASSOCIATIONS
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Keywords
Primary Health Care, Counseling, Healthcare Staff, Motor Activity, Public Health
Abstract
Background: CD133 and AXL are recognized as markers for tumor stem cells, while c-MYC is acrucial player in colon cancer (CRC) as acellular regulator.
Objective: This study aimed to evaluate the utility of AXL, c-MYC, and CD133 as prognosticindicators and their association with clinical or pathological characteristics in colon adenocarcinomas and adenomas.
Methods: A total of 156 individuals with colon adenomas (n=34) and UICC staging I–IV adenocarcinomas (n=122) underwent examination. Tissue microarrays (TMAs) containing primarytumors and adenomas were utilized to detect CD133, c-MYC, and AXL expression. Subsequently, correlations with pathological and clinical characteristics were analyzed.
Findings: Poorly differentiated adenocarcinomas and disease progression were identified assignificant contributors to poor overall prognosis, with an average life expectancy of thirty months. A one-variable analysis revealed a correlation between elevated CD133 production (35.9% of cases)and mortality, particularly in right colon tumors (44.8% of CD133+ cases). However, this association did not hold significance in multivariate analysis. c-MYC was predominantly detected in advanced-stage patients with distant metastases (15.4% of cases), while AXL expression was primarily observed in adenomas and less common in high-grade dysplasia. No general correlation was found betweenCD133 expression and decreased survival risk in CRC. Although c-MYC transcription in original tumors was associated with metastasis to other body areas, AXL expression yielded in conclusive results.
Conclusion: CD133, c-MYC, and AXL demonstrate varied associations with clinical and pathological characteristics in colon adenocarcinomas and adenomas. While CD133 and c-MYC show some correlation with prognosis and disease progression, AXL expression appears less consistent as aprognostic marker. Further investigations are warranted to elucidate their precise roles in colon cancer prognosis and treatment.
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Ayesha Erum Hadi
Junior Resident, Dr. D.Y Patil Medical College, Hospital and Research Centre, Pune, India, Department of Diagnostic Radiology
Muntaser Ibrahim Aasi Massad
University of Medicine and Pharmacy "Carol Davila" Bucharest
Faraz Waheed
Doctor, Department of Medicine, Hayatabad Medical Complex, Pakistan,
Shagufta Rasool
Student, Department of CAMB, Punjab University, Pakistan,
Maryam Naz
Lab Assistant at GGCD Nahaqi, Qurtaba University Peshawar, Pakistan
Syed Adnan Rahmat
PhD Student, Department of Epidemiology and Health Statistics, Cancer Institute, The Fourth Hospital of Hebei Medical University/The Tumor Hospital of Hebei Province, Shijiazhuang, Hebei 050011, China
Sidra Ahmad
Institute of Biotechnology and Genetic Engineering, The University of Agriculture Peshawar, Pakistan, Email: sidraa267@gmail.com