A REVIEW ON RECENT ADVANCES IN UNDERSTANDING AND MANAGING ASTHMA CLINICALLY
Main Article Content
Keywords
.
Abstract
Asthma is paroxysmal, intermittent disease of airway inflammation, all around the globe affecting people of all age groups. The global asthma report in 2014 was estimated at 334 million globally and 23.5 million in Pakistan. It is also predicted by the Global Asthma Report that in 2025 the number will rise to 100 million people. Despite emerging technologies in the diagnosis and asthma treatment, the majority of the population remain controlled poorly. However, the symptoms in some patients have been controlled through avoidance measures and pharmacological interventions. Different treatment strategies such as the use of inhaled corticosteroids (ICSs) have controlled the symptoms in asthmatic patients. If ICS therapy is ineffective alone, it can be used in combination with long-acting beta2 agonists. But other therapies such as allergen-specific immunotherapies have a significant role in disease modification but must be prescribed by healthcare professionals. This review article provides recent updates from the literature on asthma and its proper management.
References
2. Adams, R. J., Appleton, S. L., Hill, C. L., Ruffin, R. E., & Wilson, D. H. (2009). Inadequate health literacy is associated with increased asthma morbidity in a population sample. Journal of allergy and clinical immunology, 124(3), 601-603.
3. Álvarez-Gutiérrez, F. J., Medina-Gallardo, J. F., Pérez-Navarro, P., Martín-Villasclaras, J. J., Etchegoren, B. M., Romero-Romero, B., & Praena-Fernández, J. M. (2010). Relationship of the Asthma Control Test (ACT) with lung function, levels of exhaled nitric oxide and control according to the Global Initiative for Asthma (GINA). Archivos De Bronconeumología ((English Edition)), 46(7), 370-377.
4. Bateman, E. D., Hurd, S., Barnes, P., Bousquet, J., Drazen, J., FitzGerald, M., . . . Pedersen, S. (2008). Global strategy for asthma management and prevention: GINA executive summary. European Respiratory Journal, 31(1), 143-178.
5. Beasley, C., Cotter, D., & Everall, I. (2002). An investigation of the Wnt-signalling pathway in the prefrontal cortex in schizophrenia, bipolar disorder and major depressive disorder. Schizophrenia research, 58(1), 63-67.
6. Celmeli, F., Turkkahraman, D., Cetin, Z., Mihci, E., & Yegin, O. (2014). Selective IgM deficiency in a boy with ring chromosome 18. J. investig. allergol. clin. immunol, 442-444.
7. Eder, W., Ege, M. J., & von Mutius, E. (2006). The asthma epidemic. New England Journal of Medicine, 355(21), 2226-2235.
8. Frew, A. J. (2010). Allergen immunotherapy. Journal of Allergy and Clinical Immunology, 125(2), S306-S313.
9. Kemp, J. P. (2002). Clinician's Manual on Pediatric Asthma: Science Press Incorporated.
10. Koeppen-Schomerus, G., Stevenson, J., & Plomin, R. (2001). Genes and environment in asthma: a study of 4 year old twins. Archives of disease in childhood, 85(5), 398-400.
11. Krishnan, J. A., Schatz, M., & Apter, A. J. (2011). A call for action: comparative effectiveness research in asthma. Journal of Allergy and Clinical Immunology, 127(1), 123-127.
12. Lougheed, M. D., Lemière, C., Dell, S. D., Ducharme, F. M., FitzGerald, J. M., Leigh, R., . . . Becker, A. (2010). Canadian Thoracic Society Asthma Management Continuum–2010 Consensus Summary for children six years of age and over, and adults. Canadian Respiratory Journal, 17.
13. Pauwels, R. A., Pedersen, S., Busse, W. W., Tan, W. C., Chen, Y.-Z., Ohlsson, S. V., . . . Group, S. I. (2003). Early intervention with budesonide in mild persistent asthma: a randomised, double-blind trial. The Lancet, 361(9363), 1071-1076.
14. Schatz, M., & Rosenwasser, L. (2014). The allergic asthma phenotype. The Journal of Allergy and Clinical Immunology: In Practice, 2(6), 645-648.
15. Sears, W. G. (1929). The nervous complications of whooping cough. Brit. J. Child. Dis., 26(July), 191.
16. Sly, P. D., Boner, A. L., Björksten, B., Bush, A., Custovic, A., Eigenmann, P. A., . . . Helms, P. J. (2008). Early identification of atopy in the prediction of persistent asthma in children. The Lancet, 372(9643), 1100-1106.
17. Smith, S. D. (2009). Diagnosis of asthma in adults. Cmaj.
18. Walters, J. A., Tan, D. J., White, C. J., Gibson, P. G., Wood‐Baker, R., & Walters, E. H. (2014). Systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease. Cochrane Database of Systematic Reviews(9).