UTILITY OF HER2/NEU AND KI67 IMMUNOSTAINING AND THEIR CORRELATION WITH HISTOLOGICAL TYPES, GRADES & STAGING OF SURFACE EPITHELIAL TUMOURS OF OVARY
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Keywords
ovarian tumor, HER2/neu, Ki-67, targeted therapy
Abstract
Background: Ovarian carcinoma is one of the most common gynecologic malignancies in women with highest mortality rate. It was reported that ovarian cancer affected 238,719 women and causes over 150,000 deaths annually as patients were diagnosed in late stages of the disease
Aim: To evaluate the HER2/neu expression and Ki-67 expression in ovarian tumor.
Method: A hospital based prospective study was conducted in eastern India. All the cases of ovarian tumor undergone surgery were included. Results and data were analyzing in the department of pathology of Hi-Tech Medical College Bhubaneswar between2018-2020 for diagnostic accuracy by using stata.
Results: Out of 75 cases consisting 46 cases of Benign mors,9 case of border line and 20 cases of malignant tumors. Mostly elderly age groups were diagnosed as malignant tumors. HER2/neu and Ki67 expression increase with increasing grade.
Conclusion: HER2/ neu over expression in malignant tumors & can be utilized in different types of cancers for targeted therapy and more comprehensive management of patients.
References
2. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424. [PubMed] [Google Scholar]
3. WHO Classification of Tumours of Female Reproductive Organs WHO Classification of Tumours, 4th Edition, Volume 6 Edited by Kurman RJ, Carcangiu ML, Herrington CS, Young RH 2014 ISBN-13 978-92-832-2435-8
4. Yoneda A, Lendorf ME, Couchman JR, Multhaupt HA. Breast and ovarian cancers: a survey and possible roles for the cell surface heparan sulfate proteoglycans. J Histochem Cytochem. 2012;60(1):9–21. doi: 10.1369/0022155411428469 [PMC free article] [PubMed] [CrossRef] [Google Scholar]
5. Jacobs IJ, Menon U. Progress and challenges in screening for early detection of ovarian cancer. Mol Cell Proteomics. 2004;3(4):355–366. doi: 10.1074/mcp.R400006-MCP200 [PubMed] [CrossRef] [Google Scholar]
6. Badgwell D, Bast JRC. Early detection of ovarian cancer. Dis Markers. 2007;23(5–6):397–410. [PMC free article] [PubMed] [Google Scholar]
7. Jyothi Kancherla , Raghu Kalahasti , K P A Chandra Sekhar , Srikanth Babu Yarlagadda , S Parimala Devi on Histomorphological Study of Ovarian Tumors: An Institutional Experience of 2 Years Print ISSN: 2321-6379 Online ISSN: 2321-595X DOI: 10.17354/ijss/2017/301
8. Roopali Jandial , Ritu Bhagat Diversity of Ovarian Tumors: An Institutional Study Asian Pac. J. Helth Sci., 2019; 6(2):78-82 e-ISSN: 2349-0659, p-ISSN: 2350-096
9. I aNyoman Gede Budiana,1 Michelle Angelina,1 and Tjokorda Gede Astawa Pemayun Ovarian cancer: Pathogenesis and current recommendations for prophylactic surgery Published online 2019 Feb 26. doi: 10.4274/jtgga.galenos.2018.2018.0119
10. Shahin R, Ghulam S, Abid A. A clinicpathological study of ovarian cancer. Mother Child 1998;36:117-25.
11. Gupta S, Mehra M, Khattri J, Madhvi M. A study of her-2/ neu oncogene expression in benign and malignant ovarian tumors. Int J Med Res Rev [Internet]. 2020Apr.30 [cited 2024Apr.24];8(2):169-75.
12. Villella JA, Cohen S, Smith DH, Hibshoosh H, Hershman D, HER-2/neu overexpression in uterine papillary serous cancers and its possible therapeutic implications, Int J Gynecol Cancer, 2006, 16(5):1897–1902.
13. Sylvia, Mary T.; Kumar, Surendra; Dasari, Papa1The expression of immunohistochemical markers estrogen receptor, progesterone receptor, Her-2-neu, p53 and Ki-67 in epithelial ovarian tumors and its correlation with clinicopathologic variablesIndian Journal of Pathology and Microbiology 55(1):p 33-37, Jan–Mar 2012. | DOI: 10.4103/0377-4929.94852
14. Jennifer S. Woo1 , Sophia K. Apple1 , Peggy S. Sullivan1 , Jian-Yu Rao1 , Nora Ostrzega1,2 and Neda A. Moatamed Systematic assessment of HER2/neu in gynecologi Woo et al. Diagnostic Pathology (2016) 11:102 DOI 10.1186/s13000-016-0553-8 c neoplasms, an institutional experience.
15. Yusra Abdulkhaliq Qasim , Shatha Zaker Saeed , Ilham Majeed Rashid Immunohistochemical Study of P53 and Ki 67 Expression in Surface Epithelial Tumor of the Ovary DOI:10.21276/sjpm.2017.2.3.3 52 Original Research Article Saudi Journal of Pathology and Microbiology
16. Clement PB, Young HR. Sternberg’s Diagnostic Surgical Pathology, 5th Edition. Ovarian Surface Epithelial-Stromal Tumours. Lippincott Williams & Wilkins; 2010. pp. 2272–306. [Google Scholar]
17. Zaman S, Majid S, Hussain M, Chughtai O, Mahboob J, Chughtai S. A retrospective study of ovarian tumours and tumour-like lesions. Journal of Ayub Medical College Abbottabad. 2010;22(1):104–08. [PubMed] [Google Scholar]
18. Swamy GG, Satyanarayana N. Clinicopathological analysis of ovarian tumours – A study on five years samples. Nepal Medical College Journal. 2010;12(4):221–23. [PubMed] [Google Scholar]
19. Pilli GS, Sunitha KP, Dhaded AV, Yenni VV. Ovarian tumours a study of 282 cases. J Indian Med Associ. 2002;100(7):420–24. [PubMed] [Google Scholar]
20. Mankar DV, Jain GK. Histopathological profile of ovarian tumours: A twelve year institutional experience. Muller Journal of Medical Sciences and Research. 2015;6:107–11. [Google Scholar]
21. Kanthikar SN, Dravid NV, Deore PN, Nikumbh DB, Suryawanshi KH. Clinico-Histopathological analysis of neoplastic and non-neoplastic lesions of the ovary: A 3-Year prospective study in Dhule, North Maharashtra, India. Journal of Clinical and Diagnostic Research : JCDR. 2014;8(8):FC04–FC07. [PMC free article] [PubMed] [Google Scholar]
22. Seidman JD, Cho KR, Ronnett BM, Kurman RJ. In Blaustein’s Pathology of Female genital Tract. 6th edition. New York: Springer; 2010. Surface Epithelial Tumours of the Ovary. Chapter 14; pp. 682–685. [Google Scholar]
23. Mondal SK, Banyopadhyay R, Nag DR, Roychowdhury S, Mondal PK, Sinha SK. Histologic pattern, bilaterality and clinical evaluation of 957 ovarian neoplasms: A 10-year study in a tertiary hospital of eastern India. J Can Res Ther. 2011;7:433–37. [PubMed] [Google Scholar]
24. Suo Z, Karbovo E, Trope CG, Metodiev K, Nesland JM, Papillary serous carcinoma of the ovary: an ultrastructural and immunohistochemical study, Ultrastruct Pathol, 2004, 28(3):141–147.
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Dr. Swati Saswati
Assistant Professor, Department of Pathology, DRIEMS Institute of Health Sciences & Hospital, Tangi, Cuttack, Odisha, India.
Dr. K. Mohini Rao
Professor, Department of Pathology, IMS & SUM Hospital (campus II), Phulnakhara, Bhubaneswar, Odisha, India.
Dr. Chetana Pradhan
Assistant Professor, Department of Pathology, IMS & SUM Hospital (campus II), Phulnakhara, Bhubaneswar, Odisha, India.
Dr. Swagatika Agrawal
Professor, Department of Pathology, IMS & SUM Hospital (campus II), Phulnakhara, Bhubaneswar, Odisha, India.