Single-Dose Intravenous Paracetamol for Prevention or Treatment of Postoperative Pain: A Systematic Review
Main Article Content
Keywords
Paracetamol, postoperative pain, analgesia, Nonsteroidal anti-inflammatory drugs (NSAIDs), systematic review.
Abstract
One of the main goals of postoperative treatment is providing effective analgesia. Both adult and pediatric patients routinely utilize paracetamol as an analgesic and antipyretic.
Aim and Objectives: to assess the impact of systemic acetaminophen on the results of postoperative pain management when the medication was administered as a prophylactic analgesic.
Methods: This systematic review included studies that was a blinded or unblinded RCT either with parallel or cross-over design, human RCTs, the intervention group received IV paracetamol/acetaminophen, While a placebo or an active comparator was given to the comparison group. Two authors independently searched the online databases including Web of Science, Cochrane Library, Scopus MEDLINE, and EMBASE by combing MeSH and text keywords of "paracetamol and acetaminophen, I.V. intake, postoperative pain".
Conclusion: When taken as a single dosage as part of a preventative program, systemic acetaminophen is a useful strategy to enhance postoperative pain outcomes. Systemic acetaminophen also lessens vomiting and/or nausea after surgery. It is recommended that medical professionals take into account administering a solitary prophylactic dosage of systemic acetaminophen to mitigate discomfort in surgical patients.
References
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13. Moon YE, Lee YK, Lee J, Moon DE. The effects of preoperative intravenous acetaminophen in patients undergoing abdominal hysterectomy. Arch Gynecol Obstet. 2011;284:1455–60.
14. Olonisakin RP. Morphine-sparing effect of intravenous paracetamol for post operative pain management following gynaecological surgery. Afr J Med Med Sci. 2012;41(4):429–36.
15. Khalili G, Janghorbani M, Saryazdi H, Emaminejad A. Effect of preemptive and preventive acetaminophen on postoperative pain score: a randomized, double-blind trial of patients undergoing lower extremity surgery. J Clin Anesth. 2013;25(3):188–92.
16. Eftekharian H, Tabrizi R, Kazemi H, Nili M. Evaluation of a single dose intravenous paracetamol for pain relief after maxillofacial surgery: a randomized clinical trial study. J Maxillofac Oral Surg. 2014;13:478–82.
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18. Vadivelu N, Mitra S, Schermer E, Kodumudi V, Kaye AD, Urman RD. Preventive analgesia for postoperative pain control: a broader concept. Local Reg Anesth. 2014;17–22.
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20. Katz J, Clarke H, Seltzer Z. Preventive analgesia: quo vadimus? Anesth Analg. 2011;113(5):1242–53.
21. Bandey S, Singh V. Comparison between IV paracetamol and tramadol for postoperative analgesia in patients undergoing laparoscopic cholecystectomy. J Clin diagnostic Res JCDR. 2016;10(8):UC05.
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23. Perrott DA, Piira T, Goodenough B, Champion GD. Efficacy and safety of acetaminophen vs ibuprofen for treating children’s pain or fever: a meta-analysis. Arch Pediatr Adolesc Med. 2004;158(6):521–6.
24. Mahajan L, Mittal V, Gupta R, Chhabra H, Vidhan J, Kaur A. Study to compare the effect of oral, rectal, and intravenous infusion of paracetamol for postoperative analgesia in women undergoing cesarean section under spinal anesthesia. Anesth Essays Res. 2017;11(3):594–8.
25. Raffa RB, Pawasauskas J, Pergolizzi J V, Lu L, Chen Y, Wu S, et al. Pharmacokinetics of oral and intravenous paracetamol (acetaminophen) when co-administered with intravenous morphine in healthy adult subjects. Clin Drug Investig. 2018;38:259–68.
26. Jibril F, Sharaby S, Mohamed A, Wilby KJ. Intravenous versus oral acetaminophen for pain: systematic review of current evidence to support clinical decision-making. Can J Hosp Pharm. 2015;68(3):238.
27. Öncül AMT, Çimen E, Küçükyavuz Z, Cambazoğlu M. Postoperative analgesia in orthognathic surgery patients: diclofenac sodium or paracetamol? Br J Oral Maxillofac Surg. 2011;49(2):138–41.
28. Ong CKS, Seymour RA, Lirk P, Merry AF. Combining paracetamol (acetaminophen) with nonsteroidal antiinflammatory drugs: a qualitative systematic review of analgesic efficacy for acute postoperative pain. Anesth Analg. 2010;110(4):1170–9.
29. Sinatra RS, Jahr JS, Reynolds L, Groudine SB, Royal MA, Breitmeyer JB, et al. Intravenous acetaminophen for pain after major orthopedic surgery: an expanded analysis. Pain Pract. 2012;12(5):357–65.
30. Phillips SJ, Peck CJ, Pourtaheri N, Reategui A, Carney M, Dinis J, et al. Decreasing inpatient opioid use following orthognathic surgery. J Craniofac Surg. 2021;32(8):2808–11.
31. Sinatra RS, Jahr JS, Reynolds LW, Viscusi ER, Groudine SB, Payen-Champenois C. Efficacy and safety of single and repeated administration of 1 gram intravenous acetaminophen injection (paracetamol) for pain management after major orthopedic surgery. J Am Soc Anesthesiol. 2005;102(4):822–31.
32. McNicol ED, Ferguson MC, Haroutounian S, Carr DB, Schumann R. Single dose intravenous paracetamol or intravenous propacetamol for postoperative pain. Cochrane Database Syst Rev. 2016;(5).
2. Hyland SJ, Brockhaus KK, Vincent WR, Spence NZ, Lucki MM, Howkins MJ, et al. Perioperative pain management and opioid stewardship: a practical guide. In: Healthcare. MDPI; 2021. p. 333.
3. Mitra S, Carlyle D, Kodumudi G, Kodumudi V, Vadivelu N. New advances in acute postoperative pain management. Curr Pain Headache Rep. 2018;22:1–11.
4. Kaye AD, Urman RD, Rappaport Y, Siddaiah H, Cornett EM, Belani K, et al. Multimodal analgesia as an essential part of enhanced recovery protocols in the ambulatory settings. J Anaesthesiol Clin Pharmacol. 2019;35(Suppl 1):S40–5.
5. Ohashi N, Kohno T. Analgesic effect of acetaminophen: a review of known and novel mechanisms of action. Front Pharmacol. 2020;11:580289.
6. Ayoub SS. Paracetamol (acetaminophen): A familiar drug with an unexplained mechanism of action. Temperature. 2021;8(4):351–71.
7. Kim SY, Kim JM, Lee JH, Song BM, Koo BN. Efficacy of intraoperative dexmedetomidine infusion on emergence agitation and quality of recovery after nasal surgery. Br J Anaesth. 2013;111(2):222–8.
8. Barreveld A, Witte J, Chahal H, Durieux ME, Strichartz G. Preventive analgesia by local anesthetics: the reduction of postoperative pain by peripheral nerve blocks and intravenous drugs. Anesth Analg. 2013;116(5):1141–61.
9. De Oliveira Jr GS, Agarwal D, Benzon HT. Perioperative single dose ketorolac to prevent postoperative pain: a meta-analysis of randomized trials. Anesth Analg. 2012;114(2):424–33.
10. Waldron NH, Jones CA, Gan TJ, Allen TK, Habib A. Impact of perioperative dexamethasone on postoperative analgesia and side-effects: systematic review and meta-analysis. Br J Anaesth. 2013;110(2):191–200.
11. Tzortzopoulou A, McNicol ED, Cepeda MS, Francia MBD, Farhat T, Schumann R. Single dose intravenous propacetamol or intravenous paracetamol for postoperative pain. Cochrane Database Syst Rev. 2011;(10).
12. McNicol ED, Tzortzopoulou A, Cepeda MS, Francia MBD, Farhat T, Schumann R. Single-dose intravenous paracetamol or propacetamol for prevention or treatment of postoperative pain: a systematic review and meta-analysis. Br J Anaesth. 2011;106(6):764–75.
13. Moon YE, Lee YK, Lee J, Moon DE. The effects of preoperative intravenous acetaminophen in patients undergoing abdominal hysterectomy. Arch Gynecol Obstet. 2011;284:1455–60.
14. Olonisakin RP. Morphine-sparing effect of intravenous paracetamol for post operative pain management following gynaecological surgery. Afr J Med Med Sci. 2012;41(4):429–36.
15. Khalili G, Janghorbani M, Saryazdi H, Emaminejad A. Effect of preemptive and preventive acetaminophen on postoperative pain score: a randomized, double-blind trial of patients undergoing lower extremity surgery. J Clin Anesth. 2013;25(3):188–92.
16. Eftekharian H, Tabrizi R, Kazemi H, Nili M. Evaluation of a single dose intravenous paracetamol for pain relief after maxillofacial surgery: a randomized clinical trial study. J Maxillofac Oral Surg. 2014;13:478–82.
17. Truelove EC, Urrechaga E, Fernandez C, Fowler JR. Prospective, double-blind evaluation of perioperative intravenous acetaminophen and ketorolac for postoperative pain and opioid consumption after endoscopic carpal tunnel release. HAND. 2021;16(6):785–91.
18. Vadivelu N, Mitra S, Schermer E, Kodumudi V, Kaye AD, Urman RD. Preventive analgesia for postoperative pain control: a broader concept. Local Reg Anesth. 2014;17–22.
19. Dahl JB, Kehlet H. Preventive analgesia. Curr Opin Anesthesiol. 2011;24(3):331–8.
20. Katz J, Clarke H, Seltzer Z. Preventive analgesia: quo vadimus? Anesth Analg. 2011;113(5):1242–53.
21. Bandey S, Singh V. Comparison between IV paracetamol and tramadol for postoperative analgesia in patients undergoing laparoscopic cholecystectomy. J Clin diagnostic Res JCDR. 2016;10(8):UC05.
22. Toms L, McQuay HJ, Derry S, Moore RA. Single dose oral paracetamol (acetaminophen) for postoperative pain in adults. Cochrane database Syst Rev. 2008;(4).
23. Perrott DA, Piira T, Goodenough B, Champion GD. Efficacy and safety of acetaminophen vs ibuprofen for treating children’s pain or fever: a meta-analysis. Arch Pediatr Adolesc Med. 2004;158(6):521–6.
24. Mahajan L, Mittal V, Gupta R, Chhabra H, Vidhan J, Kaur A. Study to compare the effect of oral, rectal, and intravenous infusion of paracetamol for postoperative analgesia in women undergoing cesarean section under spinal anesthesia. Anesth Essays Res. 2017;11(3):594–8.
25. Raffa RB, Pawasauskas J, Pergolizzi J V, Lu L, Chen Y, Wu S, et al. Pharmacokinetics of oral and intravenous paracetamol (acetaminophen) when co-administered with intravenous morphine in healthy adult subjects. Clin Drug Investig. 2018;38:259–68.
26. Jibril F, Sharaby S, Mohamed A, Wilby KJ. Intravenous versus oral acetaminophen for pain: systematic review of current evidence to support clinical decision-making. Can J Hosp Pharm. 2015;68(3):238.
27. Öncül AMT, Çimen E, Küçükyavuz Z, Cambazoğlu M. Postoperative analgesia in orthognathic surgery patients: diclofenac sodium or paracetamol? Br J Oral Maxillofac Surg. 2011;49(2):138–41.
28. Ong CKS, Seymour RA, Lirk P, Merry AF. Combining paracetamol (acetaminophen) with nonsteroidal antiinflammatory drugs: a qualitative systematic review of analgesic efficacy for acute postoperative pain. Anesth Analg. 2010;110(4):1170–9.
29. Sinatra RS, Jahr JS, Reynolds L, Groudine SB, Royal MA, Breitmeyer JB, et al. Intravenous acetaminophen for pain after major orthopedic surgery: an expanded analysis. Pain Pract. 2012;12(5):357–65.
30. Phillips SJ, Peck CJ, Pourtaheri N, Reategui A, Carney M, Dinis J, et al. Decreasing inpatient opioid use following orthognathic surgery. J Craniofac Surg. 2021;32(8):2808–11.
31. Sinatra RS, Jahr JS, Reynolds LW, Viscusi ER, Groudine SB, Payen-Champenois C. Efficacy and safety of single and repeated administration of 1 gram intravenous acetaminophen injection (paracetamol) for pain management after major orthopedic surgery. J Am Soc Anesthesiol. 2005;102(4):822–31.
32. McNicol ED, Ferguson MC, Haroutounian S, Carr DB, Schumann R. Single dose intravenous paracetamol or intravenous propacetamol for postoperative pain. Cochrane Database Syst Rev. 2016;(5).
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Published
Nov 22, 2022
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How to Cite
1-Abdullah Ahmed hussain, 2-Ahmad Adel Samarkandi, 3-Faisal Mohammed Hinkish, 4-Fears Osama Alghefari, 5-Abdullah Ali H Alkhairi, 6-Norah Abdullah Alasmri, 7-Mosaab Mohammed Saem Aldahr, 8-Faisal Ahmed Alomari,. (2022). Single-Dose Intravenous Paracetamol for Prevention or Treatment of Postoperative Pain: A Systematic Review. Journal of Population Therapeutics and Clinical Pharmacology, 29(03), 781-786. https://doi.org/10.53555/jptcp.v29i03.5852
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All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1-Abdullah Ahmed hussain, 2-Ahmad Adel Samarkandi, 3-Faisal Mohammed Hinkish, 4-Fears Osama Alghefari, 5-Abdullah Ali H Alkhairi, 6-Norah Abdullah Alasmri, 7-Mosaab Mohammed Saem Aldahr, 8-Faisal Ahmed Alomari,. (2022). Single-Dose Intravenous Paracetamol for Prevention or Treatment of Postoperative Pain: A Systematic Review. Journal of Population Therapeutics and Clinical Pharmacology, 29(03), 781-786. https://doi.org/10.53555/jptcp.v29i03.5852