OPTIMIZING HEALTHCARE RESOURCES: SODIUM-GLUCOSE COTRANSPORTER INHIBITORS FOR CARDIOVASCULAR RISK REDUCTION IN TYPE 2 DIABETES MELLITUS
Main Article Content
Keywords
glucose, sodium, cotransporter, diabetes, cardioprotection, cost-effectiveness
Abstract
Introduction: Type 2 diabetes mellitus (T2DM) poses a significant economic burden due to its association with cardiovascular complications, making it a leading cause of premature mortality and straining healthcare systems.
Methods: A systematic electronic search was conducted for clinical trials published between January 2015 and January 2023 in PubMed, Scopus, Web of Science, and ScieLO databases. These trials evaluated the safety and efficacy of sodium-glucose cotransporter inhibitors (SGLT2i) in patients with T2DM and established cardiovascular disease, focusing on standard treatment and cost-effectiveness analysis.
Results: The addition of SGLT2i to standard therapy led to notable reductions in rates of acute myocardial infarction, stroke, cardiovascular death, and hospitalization for heart failure. The observed decrease in cardiovascular events offset the costs associated with SGLT2i therapy, demonstrating a favorable utilization of healthcare resources.
Conclusions: Given that cardiovascular events are the primary cause of mortality in patients with T2DM and cardiovascular disease, there is a pressing need for the development of therapies that not only improve glycemic control but also mitigate cardiovascular risks. These findings underscore the emergence of an evidence-based approach to managing such patients, heralding a new era in clinical practice.
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Moeez Saqib
House Officer Mayo Hospital, Department of Internal Medicine, King Edward Medical University, Lahore, Pakistan
Mbony Joshua Cho
Medical Doctor, Department of General Medicine, Santa District Hospital Cameroon / Presbyterian Health Complex Yaounde - Cameroon
Dr. Nishat waqas
Doctor, Dow University of Health Sciences, Department of Family Medicine, Pakistan
Amgad Samir Abdelmageed Mohamed Elfeki
Internal Medicine Resident in Egyptian Board 3rd Year, Department of Internal Medicine, Graduated From Cairo University, Egypt
FNU Vishal
General Physician, Department of Medicine, Chandka Medical College, Pakistan
Aarti Kumari
MBBS, Liaquat University of Medical and Health Sciences Jamshoro, Pakistan
Muodiaju Chiazor Joan
Laboratory Research Analyst, Department of Surgery, Center for Human Systems Immunology, Duke University, USA
Ahmed Samir Abdelmageed Mohamed Elfiki
Internal Medicine Specialist and Resident in Egyptian Board 3rd Year, Department of Internal Medicine, Graduated From Cairo University, Master Degree in Shams University, Egypt