EVALUATION OF HEAT SHOCK PROTEINS AND OXIDATIVE STRESS MARKERS IN SERUM IN PATIENTS WITH MYOCARDIAL INFRACTION
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Keywords
Atherosclerosis, Myocardial infarction, Heat shock proteins, Cardiovascular diseases
Abstract
Background: Atherosclerosis, a chronic inflammatory disease, leads to arterial narrowing and cardiovascular events like myocardial infarction. Heat shock proteins (HSPs) are implicated in cellular response to stress, including oxidative damage. Understanding the roles of HSPs in atherosclerosis and myocardial infarction could offer insights into disease mechanisms and potential therapeutic targets.
Objectives: The objectives of this study are to investigate the association between heat shock proteins (HSPs) and cardiovascular diseases, particularly atherosclerosis and myocardial infarction. This includes examining the role of HSPs in oxidative stress, inflammation, and cellular protection, with potential implications for diagnosis and therapeutic interventions.
Material and methods: Patients diagnosed with myocardial infarction were selected from January 2018 to January 2019 at Bacha Khan Medical College Mardan's Biochemistry department. Inclusion criteria comprised individuals aged 35 to 75, diagnosed with myocardial infarction. Exclusion criteria included congenital heart disease and pregnancy. Blood samples were collected and analyzed using various techniques, including ELISA for HSPs and spectrophotometry for antioxidant enzymes.
Results: Demographic and hematological profiles of myocardial infarction patients and control subjects are presented. Circulating stress biomarkers and levels of heat shock proteins in myocardial infarction patients are also reported.
Conclusion: Heat shock proteins, including HSP27, HSP60, and HSP90, play critical roles in cardiovascular diseases such as atherosclerosis and myocardial infarction. Understanding their functions and levels in patients may provide valuable insights for diagnosis and treatment.
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Nadia Halem
Associate Professor Biochemistry Ayub Medical College, Abbottabad – Pakistan
Ayesha Naureen Awan
Associate Professor Biochemistry Ayub Medical College, Abbottabad – Pakistan
Mohammad Israr
Assistant Professor Biochemistry Department, Bacha Khan Medical College, Mardan - Pakistan
Aziz Ur Rehman
Associate Professor Biochemistry Department, Rehman Medical College, Hayatabad Peshawar - Pakistan
Sofia Shoukat
Assistant Professor Biochemistry Department, Ayub Medical College, Abbottabad - Pakistan
Madeeha Jadoon
Assistant Professor Biochemistry Department, Women Medical and Dental College, Abbottabad - Pakistan