COMPARATIVE ANALYSIS OF RENAL STONE INCIDENCE BETWEEN DIABETIC AND NON-DIABETIC PATIENTS ON ULTRASOUND: A SINGLE CENTRE STUDY
Main Article Content
Keywords
Renal stone, Nephrolithiasis, Ultrasound, Sonography, Diabetes
Abstract
Objective:To ascertain the renal stone disease incidence in diabetic vs. non-diabetic individuals.
Materials and methods:This cross-sectional descriptive study, conducted over one year at Department of Radiology, Chandka Medical College Hospital, Shaheed Muhtarma Benazeer Bhutto Medical University, Larkana aimed to assess nephrolithiasis incidence in diabetic and non-diabetic cohorts. Eligible participants, visiting the ultrasound clinic for abdominal ultrasound, were included, with diabetic patients aged over 40 and on hypoglycemic agents or insulin for ≥5 years. Exclusions comprised those with diabetes complications, urinary calculi history, or urogenital disorders. Out of 140 participants, detailed clinical data were collected, and abdominal scans performed by a sonographer. IBM-SPSS version-23.0 analyzed the data.
Results:Among 140 participants, males represented 61.4%, with half having diabetes. The age range spanned 19-85 years, with the highest prevalence in the 49-62 age group. Renal stone diagnosis was prevalent in 17.14% of diabetic participants compared to 5.71% of non-diabetics. Mean stone size was higher in diabetics (3.768 mm) than non-diabetics (2.512 mm). Stone numbers varied, with most having one stone.
Conclusion:In conclusion, diabetic patients, especially males, face a higher risk of kidney stones. The study recommends routine ultrasound screening for asymptomatic renal stone disease in diabetic individuals to prevent chronic renal damage and acute kidney injuries.
References
2. Aggarwal KP, Narula S, Kakkar M, Tandon C. Nephrolithiasis: molecular mechanism of renal stone formation and the critical role played by modulators. Biomed Res Int. 2013; 2013:292953. [PMC free article] [PubMed]
3. Brisbane, W., Bailey, M. R., & Sorensen, M. D. (2016). An overview of kidney stone imaging techniques. Nature reviews. Urology, 13(11), 654–662. https://doi.org/10.1038/nrurol.2016.154
4. Abate N, Chandalia M, Cabo-Chan AV, Moe OW, Sakhaee K. The metabolic syndrome and uric acid nephrolithiasis: novel features of renal manifestation of insulin resistance. Kidney Int. 2004 Feb;65(2):386-92. [PubMed]
5. Kumar, M., Dev, S., Khalid, M. U., Siddenthi, S. M., Noman, M., John, C., Akubuiro, C., Haider, A., Rani, R., Kashif, M., Varrassi, G., Khatri, M., Kumar, S., & Mohamad, T. (2023). The Bidirectional Link Between Diabetes and Kidney Disease: Mechanisms and Management. Cureus, 15(9), e45615. https://doi.org/10.7759/cureus.45615
6. Diabetic kidney disease: past and present. Akhtar M, Taha NM, Nauman A, Mujeeb IB, Al-Nabet AD. Adv Anat Pathol. 2020;27:87–97. [PubMed] [Google Scholar]
7. The global burden of diabetic kidney disease: time trends and gender gaps. Thomas B. Curr Diab Rep. 2019;19:18. [PubMed] [Google Scholar]
8. Diabetic kidney disease in adolescents with type 2 diabetes: new insights and potential therapies. Bjornstad P, Cherney DZ, Maahs DM, Nadeau KJ. Curr Diab Rep. 2016;16:11. [PMC free article] [PubMed] [Google Scholar]
9. Zulqar M, Shabbir H, Kanwal I, Zafar F, Taj A, Nadeem M, et al. Sonographic Assessment of Nephrolithiasis in Patients of Type II Diabetes in the 30 to 50 Year Age Group. Journal of Health and Medical Sciences. 2019 Dec 30; 2(4). doi: 10.31014/aior.1994.02.04.85
10. Khan BB, Qureshi KA, Ahmed A, Kumar A, Hashami U. Incidence of Renal Stones In Diabetic Patients. Turkish Journal of Physiotherapy and Rehabilitation. 32:3.
11. Spivacow F, Del Valle E, Boailchuk J, Allo PM, Pailler M. Metabolic Risk Factors in Patients with Kidney Stones with and without Type 2 Diabetes. Research Square. doi: 10.21203/rs.3.rs-855238/v1.
12. Jastaniah SD, Alsayed NM, Awad IA, Fida HR, Elniel HH. Evaluation of renal disorders in type 2 diabetic patients using ultrsonography. Open Journal of Medical Imaging. 2013 Dec; 2013. doi: 10.4236/ojmi. 2013.34024
13. Weinberg, A. E., Patel, C. J., Chertow, G. M., & Leppert, J. T. (2014). Diabetic severity and risk of kidney stone disease. European urology, 65(1), 242–247. https://doi.org/10.1016/j.euru ro.2013.03.026
14. Wondmkun Y. T. (2020). Obesity, Insulin Resistance, and Type 2 Diabetes: Associations and Therapeutic Implications. Diabetes, metabolic syndrome and obesity : targets and therapy, 13, 3611–3616. https://doi.org/10.2147/DMSO.S275898