SYNTHESIS, CHARACTERIZATION, AND BIOLOGICAL EVALUATION OF 3-BROMO ISOQUINOLINE DERIVATIVES: POTENTIAL LEAD MOLECULES FOR ANALGESIC AND ANTI-INFLAMMATORY AGENTS
Main Article Content
Keywords
N-heterocycles, bioactive compounds, 3-bromo isoquinoline derivatives, Suzuki coupling reaction, analgesic activity, and anti-inflammatory activity
Abstract
Nitrogen containing heterocycles have gained massive research attention since they are frequently found as naturally occurring bioactive compounds. This status of N-heterocycles makes it dynamic to design methods to expand their synthetic efficacies and review the effects of their modifications on biological systems. In the present study we synthesized several 3-bromo isoquinoline derivatives which are nitrogen-containing arylated heterocycles via Suzuki coupling reaction. The prepared compounds were physically and chemically characterized by Fourier transform infrared (FTIR), 1H NMR, and 13C NMR spectral data. Biological screening such as antibacterial, antifungal, antioxidant, analgesic, and anti-inflammatory, COX2 inhibitor activities along with toxicity concerns were checked. Molecular docking studies were performed to confirm the ligand protein binding and type of binding interactions resulting in the biological activities of the compounds. Therefore, our study proposed that the 3-bromo isoquinoline derivatives hold noteworthy analgesic and anti-inflammatory activity and have very positive toxicity values. These facts serve as basis that keeping the activity and safety considerations these molecules might attend researcher’s attention as a lead molecule for the discovery of potent analgesic and anti-inflammatory agents.
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Tariq Javed
Gomal Centre of Pharmaceutical Sciences, Faculty of Pharmacy, Gomal University, D .l. Khan.29111 Pakistan
Hashmat Ullah
Gomal Centre of Pharmaceutical Sciences, Faculty of Pharmacy, Gomal University, D. l. Khan.29111 Pakistan
Sheikh Abdur Rashid
Gomal Centre of Pharmaceutical Sciences, Faculty of Pharmacy, Gomal University, D .l. Khan.29111 Pakistan
Muhammad Tariq Khan
Faculty of Pharmacy, Capital University of Science and Technology, Islamabad, 44000 Pakistan
Nadia Shamshad Malik
Faculty of Pharmacy, Capital University of Science and Technology, Islamabad, 44000 Pakistan
Ahmed Sadiq Sheikh
Faculty of Pharmacy, My University, Islamabad, 44000 Pakistan
Nitasha Gohar
Faculty of Pharmacy, Capital University of Science and Technology, Islamabad, 44000 Pakistan
Ayesha Rashid
Department of Pharmacy, The Women University Multan, 61000, Pakistan
Amina Riaz
Department of Pharmacy, The Women University Multan, 61000, Pakistan
Muhammad Atta ur Rehman
Institute of Chemical Sciences, Gomal University, D. l. Khan.29111, Pakistan