TO STUDY THE DESIGN AND BIOPHARMACEUTICAL EVALUATION OF NANOPARTICLES CONTAINING 5-FLUOROURACIL (5-FLUORO-H,3-H-PRIMIDINE2,4-DIONE)

Abstract

Cancer is a major public health concern in both developed and developing countries. Now a days, the treatments of cancer categorizes   in to 5 classes, Surgery, Radiation, Chemotherapy, targeted and immunotherapy.  Cancer   chemotherapy   is   one   the   major   way to   treat   cancer without medical assistants. The main aim of the ideal cancer chemotherapy is to deliver the correct   amount of   drug   with   desired   controlled   rate   and  sufficiently  longer  duration  of  time  to  the  site  of  action(Tumor cells)to  obtain  the  desired  therapeutic response. Traditional cancer chemotherapy is based on the promise that tumor cells are more likely to be killed by anticancer drugs because of the faster proliferation of those cancer cells. However, in reality most of the drugs cannot differentiate cancer cells from the normal cells. This results in the undesirable effect of the drug because of the lack of selectivity. To minimize this risk, the development of tumor targeted drug delivery systems of anti-cancerous agents is necessary. The success of therapy depends on the selection of ideal carriers’ system that can deliver the drug selectively to tumor cells.  These carries include nanoparticles, nanotubes, nanorods, dendrimers, micelles, solid lipid nanoparticles, microspheres.