Asthma: distribution, familial association, evaluation a cross sectional study in north India
Main Article Content
Keywords
Asthma, Demography, genetic inheritance, Symptoms, Evaluation
Abstract
All over the world asthma is a major cause of morbidity. To understand it we have to find out its associations, either if it is due to environmental factors or due to genetic inheritance or both are interacting in its etiology. In this study we found that some age groups (41 to 50 years) are at higher risk of asthma incidence than others and also the female sex was more prone to have asthma attacks during these years of life. We also found that other lung conditions like tuberculosis was also associated with asthma poor control or sometimes also precipitates acute attacks. As we also evaluated our patients with X-ray and spirometry, so we found that instead of good evidence of superiority of spirometry over X-ray in diagnosis and evaluation of asthma, even then patients were not interested in that investigation. In our evaluation of four cardinal symptoms of asthma we concluded that chest tightness was the first symptom that patient experience and also the last symptom to be relieved by treatment followed by breathlessness. We also found that most of patients approaching physician were follow-up patients and only 15% had familial history of asthma.
References
2. Verma R. Resource scarcity in India New Challenges and Threats to U.S. Prosperity and Security. In: Reed D (Ed). In Pursuit of Prosperity. 1sted. New York: Routledge; 2015. p215-40.
3. The International Union against Tuberculosis and Lung Disease. The Global Asthma Report 2011. Paris, France: The International Study of Asthma and Allergies in childhood, 2011
4. Dutta MM. Health insurance sector in India: an analysis of its performance. XJM. 2020; 172): 97-109
5. Pal R, Dahal S, Pal S. Prevalence of bronchial asthma in Indian children. Indian J Community Med. 2009 Oct;34(4):310-16.
6.To T, Stanojevic S, Moores G, Gershon AS, Bateman ED, Cruz AA, et al. Global asthma prevalence in adults: Findings from the cross sectional world health survey. BMC Public Health. 2012;12:204
7.The International Union against Tuberculosis and Lung Disease. The Global Asthma Report 2011. Paris, France: The International Study of Asthma and Allergies in childhood, 2011
8.Pandey A, Tripathi P, Pandey RD. Prescription pattern in asthma therapy at Gorakhpur hospitals. Lung India. 2010;27(1):8-10.
9.Dharmage SC, Perret JL, Custovic A. Epidemiology of Asthma in Children and Adults. Front Pediatr. 2019;7:246
10.Agrawal S, Pearce N, Ebrahim S. Prevalence and risk factors for self-reported asthma in an adult Indian population: A cross-sectional survey. Int J Tuberc Lung Dis. 2013;17:275-82
11. Aggarwal AN, Chaudhry K, Chhabra SK, D’Souza GA, Gupta D, Jindal SK,et al.; Asthma Epidemiology Study Group. Prevalence and risk factors for bronchial asthma in Indian adults: A multicentre study. Indian J Chest Dis Allied Sci. 2006;48:13-22
12. Jindal SK, Aggarwal AN, Gupta D, Agarwal R, Kumar R, Kaur T, et al. Indian study on epidemiology of asthma, respiratory symptoms and chronic bronchitis in adults (INSEARCH). Int J Tuberc Lung Dis. 2012;16:1270-7
13.Trivedi N, Acharya HR, Barvaliya MJ, Tripathi CB. Prescribing pattern in patients of asthma visiting outpatient departments of tertiary care hospital: a cross sectional, observational study. Int J Basic ClinPharmacol. 2017;6:587-91
14. Brigham EP. Diagnosis of asthma: diagnosis testing. IFAR. 2015; 5(S1): S27-30
15. McCracken JL, Veeranki SP, Ameredes BT, Calhoun WJ. Diagnosis and Management of Asthma in Adults: A Review. JAMA. 2017 Jul 18;318(3):279-90
16. Global initiative for asthma. Asthma management and prevention for adults and children older than 5 years. Paris, France:2019
17. Quirt J, Hildebrand KJ, Mazza J, Noya F, Kim H. Asthma. Allergy Asthma ClinImmunol. 2018;14(2):50
18. Kaplan AG, Balter MS, Bell AD, Kim H, McIvor RA. Diagnosis of asthma in adults.CMAJ. 2009;181(10):E210-20
19. Saglani S, Menzie-Gow AN. Approaches to Asthma Diagnosis in Children and Adults. Front Pediatr. 2019;7:148
20krishnasailaja, Abbaraju. (2014). An overall review on chronic asthma. 2. 275-279
21Quirt J, Hildebrand KJ, Mazza J, Noya F, Kim H. Asthma. Allergy Asthma ClinImmunol. 2018;14(2):50
22. Globe G, Martin M, Schatz M, et al. Symptoms and markers of symptom severity in asthma--content validity of the asthma symptom diary. Health Qual Life Outcomes. 2015;13:21
23. He Z, Feng J, Xia J, Wu Q, Yang H, Ma Q. Frequency of Signs and Symptoms in Persons With Asthma. Respir Care. 2020 Feb;65(2):252-64
24. Reed CE. The natural history of asthma.J Allergy ClinImmunol. 2006 Sep;118(3):543-8
25. Wiener AS, Zieve I, Fries JH. The inheritance of allergic disease. Ann Eugenics. 1936;7:141–62
26. Thomsen SF Exploring the origins of asthma: Lessons from twin studies. EurClinRespir J. 2014;1(1):10
27. Sibbald B, Horn ME, Brain EA, Gregg I. Genetic factors in childhood asthma. Thorax. 1980;35(9):671-4
28. Bijanzadeh M, Mahesh PA, Ramachandra NB. An understanding of the genetic basis of asthma. Indian J Med Res. 2011;134(2):149-61.
29. Thomsen SF. Genetics of asthma: an introduction for the clinician. EurClinRespir J. 2015;2:10
30. National current asthma prevalence 2017 [Internet]. Washington: Center for Disease Control and Prevention (CDC) 2017. Available from :https://www.cdc.gov/asthma/most_recent_national_asthma_data.htm [Cited 30 November 2019]
31. Sly PD, Kusel M, Holt PG. Do early-life viral infections cause asthma? J Allergy ClinImmunol. 2010;125:1202-5
32 De Luca G, Olivieri F, Melotti G, Aiello G, Lubrano L, Boner AL. Fetal and early postnatal life roots of asthma. J Matern Fetal Neonatal Med. 2010; 23(S3):80‑3
33. Bijanzadeh M, Mahesh PA, Ramachandra NB. An understanding of the genetic basis of asthma. Indian J Med Res. 2011;134(2):149-61.