BIOCHEMICAL EVALUATION OFVACCINIUM MACROCARPON AND EMBLICA OFFICINALIS IN ALLEVIATING ULCERATIVE COLITIS IN MICE
Main Article Content
Keywords
V. macrocarpon, E. officinalis, Ulcerative colitis, Mice, Biochemical evaluation, Ulcerative Colitis, Therapeutic potential.
Abstract
The chronic inflammatory disease ulcerative colitis, which affects the colon and rectum, causes much
healthcare morbidity and burden. Because conventional medicine couldn't relieve or prevent
symptoms, complementary and alternative therapies were sought. This mouse model study examines
the biochemical effects of cranberry and amla extracts on ulcerative colitis symptom. Evidence
supports the claim that these compounds reduce oxidative stress markers, retain mucosal membrane
integrity in colitic mice, and lower pro-inflammatory cytokines (e.g., TNF-α and IL-6). Because of
their complex action mechanisms, they target many pathogenic pathways involved in UC
pathophysiology. This makes them effective. UC patients can receive individualized and holistic
treatment by incorporating evidence-based research on natural products and herbal remedies. Due to
natural and herbal ingredients, this is possible. Patients would have access to additional therapeutic
alternatives as a result of this circumstance, which would ultimately result in an increase in the quality
of life that they experience.
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3. Ahmad, B., Hafeez, N., Rauf, A., Bashir, S., Linfang, H., Rehman, M.-u., . . . Shariati, M. A. (2021). Phyllanthus emblica: A comprehensive review of its therapeutic benefits. South African journal of botany, 138, 278-310.
4. Akkol, E. K., Karpuz, B., Sobarzo-Sánchez, E., & Khan, H. (2020). A phytopharmacological overview of medicinal plants used for prophylactic and treatment of colitis. Food and chemical toxicology, 144, 111628.
5. Alaqeel, N. K., AlSheikh, M. H., & Al-Hariri, M. T. (2022). Quercetin nanoemulsion ameliorates neuronal dysfunction in experimental Alzheimer’s disease model. Antioxidants, 11(10), 1986.
6. Amin, R., Thalluri, C., Docea, A. O., Sharifi‐Rad, J., & Calina, D. (2022). Therapeutic potential of cranberry for kidney health and diseases. eFood, 3(5), e33.
7. Armuzzi, A., & Liguori, G. (2021). Quality of life in patients with moderate to severe ulcerative colitis and the impact of treatment: a narrative review. Digestive and Liver Disease, 53(7), 803-808.
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10. Attallah, N. G., El-Kadem, A. H., Negm, W. A., Elekhnawy, E., El-Masry, T. A., Elmongy, E. I., . . . Ragab, A. E. (2021). Promising antiviral activity of Agrimonia pilosa phytochemicals against severe acute respiratory syndrome coronavirus 2 supported with in vivo mice study. Pharmaceuticals, 14(12), 1313.
11. Attia, S. M., Varadharajan, K., Shanmugakonar, M., Das, S. C., & Al-Naemi, H. A. (2022). Cadmium: an emerging role in adipose tissue dysfunction. Exposure and health, 14(1), 171-183.
12. Baars, E. W., Zoen, E. B.-v., Breitkreuz, T., Martin, D., Matthes, H., Schoen-Angerer, T. v., . . . Patijn, O. (2019). The contribution of complementary and alternative medicine to reduce antibiotic use: a narrative review of health concepts, prevention, and treatment strategies. Evidence-Based Complementary and Alternative Medicine, 2019.
13. Baranao, R., Piazza, A., Rumi, L., & Fried, E. P. d. (1997). Determination of IL‐1 and IL‐6 levels in human embryo culture‐conditioned media. American journal of reproductive immunology, 37(2), 191-194.
14. Barbara, G., Barbaro, M. R., Fuschi, D., Palombo, M., Falangone, F., Cremon, C., . . . Stanghellini, V. (2021). Inflammatory and microbiota-related regulation of the intestinal epithelial barrier. Frontiers in Nutrition, 8, 718356.
15. Bobis, O., Nayik, G. A., Wagay, J. A., Farooq, U., Zehra, A., & Nanda, V. (2020). Cranberry. Antioxidants in fruits: Properties and health benefits, 479-505.
16. Bologa, C. (2021). Foods that promote health. Foods That Harm, Foods That Promote Health: A Biochemical and Nutritional Perspective in Health and Disease Prevention. Irvine, CA, USA: Universal Publishers Inc, 181-213.
17. Bouyahya, A., Omari, N. E., El Hachlafi, N., Jemly, M. E., Hakkour, M., Balahbib, A., . . . Khouchlaa, A. (2022). Chemical compounds of berry-derived polyphenols and their effects on gut microbiota, inflammation, and cancer. Molecules, 27(10), 3286.
18. Cai, X., Han, Y., Gu, M., Song, M., Wu, X., Li, Z., . . . Xiao, H. (2019). Dietary cranberry suppressed colonic inflammation and alleviated gut microbiota dysbiosis in dextran sodium sulfate-treated mice. Food & Function, 10(10), 6331-6341.
19. Cai, Z., Wang, S., & Li, J. (2021). Treatment of inflammatory bowel disease: a comprehensive review. Frontiers in medicine, 8, 765474.
20. Cheraghi, E., & Roshanaei, K. (2019). The protective effect of curcumin against aluminum chloride-induced oxidative stress and hepatotoxicity in rats. Pharmaceutical and Biomedical Research.
21. Cox-Georgian, D., Ramadoss, N., Dona, C., & Basu, C. (2019). Therapeutic and medicinal uses of terpenes. Medicinal plants: from farm to pharmacy, 333-359.
22. Elmaghraby, D. A., Alsalman, G. A., Alawadh, L. H., Al-Abdulqader, S. A., Alaithan, M. M., & Alnuwaysir, B. I. (2023). Integrated traditional herbal medicine in the treatment of gastrointestinal disorder: the pattern of use and the knowledge of safety among the Eastern Region Saudi population. BMC Complementary Medicine and Therapies, 23(1), 1-12.
23. Elnaas, A. R. (2020). Escaping Bio-Assay Guided Isolation: Nature's Tools for Chemical Biology.
24. Gajendran, M., Loganathan, P., Jimenez, G., Catinella, A. P., Ng, N., Umapathy, C., . . . Hashash, J. G. (2019). A comprehensive review and update on ulcerative colitis. Disease-a-month, 65(12), 100851.
25. Gill, P. K. (2023). Lactic Acid Bacteria as Probiotics: Current Status and Future Prospects. Asian Journal of Microbiology and Biotechnology, 120-139.
26. Golovinskaia, O., & Wang, C.-K. (2021). Review of functional and pharmacological activities of berries. Molecules, 26(13), 3904.
27. Gupta, M., Mishra, V., Gulati, M., Kapoor, B., Kaur, A., Gupta, R., & Tambuwala, M. M. (2022). Natural compounds as safe therapeutic options for ulcerative colitis. Inflammopharmacology, 30(2), 397-434.
28. Haddeland, K., Marthinsen, G. N., Söderhamn, U., Flateland, S. M., & Moi, E. M. (2022). Experiences of using the ISBAR tool after an intervention: A focus group study among critical care nurses and anaesthesiologists. Intensive and Critical Care Nursing, 70, 103195.
29. Hussain, S. Z., Naseer, B., Qadri, T., Fatima, T., & Bhat, T. A. (2021). Anola (Emblica officinalis): Morphology, Taxonomy, Composition and Health Benefits. In Fruits Grown in Highland Regions of the Himalayas: Nutritional and Health Benefits (pp. 193-206): Springer.
30. Ikram, A., Khalid, W., Aziz, M., Arif, M. A., Jha, R. P., Khalid, M. Z., . . . Rahim, M. A. (2021). Nutritional and biochemical composition of amla (Emblica officinalis) and its therapeutic impact: A review. Acta Scientific NUTRITIONAL HEALTH (ISSN: 2582-1423), 5(2).
31. Iqbal, M. (2022). Complementary and Alternative Medicinal Approaches for Enhancing Immunity: CRC Press.
32. Jabeen, K., Rehman, K., Akash, M. S. H., Nadeem, A., & Mir, T. M. (2023). Neuroprotective and cardiometabolic role of vitamin E: alleviating neuroinflammation and metabolic disturbance induced by AlCl3 in rat models. Biomedicines, 11(9), 2453.
33. Jalwal, P., Singh, B., & Kumar, A. A COMPREHENSIVE REVIEW ON DISSOLUTION TESTING.
34. Kadariya, Y., Sementino, E., Shrestha, U., Gorman, G., White, J. M., Ross, E. A., . . . Testa, J. R. (2022). Inflammation as a chemoprevention target in asbestos-induced malignant mesothelioma. Carcinogenesis, 43(12), 1137-1148
35. Kaur, S., Gupta, K. B., Kumar, S., Upadhyay, S., Mantha, A. K., & Dhiman, M. (2022). Methods to detect nitric oxide and reactive nitrogen species in biological sample. In Cancer Biomarkers: Methods and Protocols (pp. 69-76): Springer.
36. Khalil, R. R., Mustafa, E. T. M., & Fakri, Y. (2021). Various Promising Biological Effects of Cranberry Extract: A Review. Clinical Schizophrenia & Related Psychoses, 15.
37. Kumar, S., Verma, M., Hajam, Y. A., & Kumar, R. (2024). Honey infused with herbs: A boon to cure pathological diseases. Heliyon.
38. Kunchana, K., Jarisarapurin, W., Chularojmontri, L., & Wattanapitayakul, S. K. (2021). Potential use of amla (Phyllanthus emblica L.) fruit extract to protect skin keratinocytes from inflammation and apoptosis after UVB irradiation. Antioxidants, 10(5), 703.
39. Li, X., Wu, L., Wu, R., Sun, M., Fu, K., Kuang, T., & Wang, Z. (2022). Comparison of medicinal preparations of Ayurveda in India and five traditional medicines in China. Journal of Ethnopharmacology, 284, 114775.
40. Liaquat, L., Sadir, S., Batool, Z., Tabassum, S., Shahzad, S., Afzal, A., & Haider, S. (2019). Acute aluminum chloride toxicity revisited: Study on DNA damage and histopathological, biochemical and neurochemical alterations in rat brain. Life Sciences, 217, 202-211.
41. Majeed, M., Nagabhushanam, K., Lawrence, L., Nallathambi, R., Thiyagarajan, V., & Mundkur, L. (2021). Boswellia serrata extract containing 30% 3-acetyl-11-keto-boswellic acid attenuates inflammatory mediators and preserves extracellular matrix in collagen-induced arthritis. Frontiers in Physiology, 12, 735247.
42. Manful, C. F., Hameed, A., & Thomas, R. H. (2023). Berries. In Functional foods and their implications for health promotion (pp. 161-217): Elsevier.
43. Martins-Gomes, C., Nunes, F. M., & Silva, A. M. (2024). Natural Products as Dietary Agents for the Prevention and Mitigation of Oxidative Damage and Inflammation in the Intestinal Barrier. Antioxidants, 13(1), 65.
44. Masoodi, H. (2020). Effect of polyphenol-rich beverages made with Citrus and maqui fruits added with low-caloric sweeteners in overweight subjects.
45. Mayegowda, S. B., Ng, M., Alghamdi, S., Atwah, B., Alhindi, Z., & Islam, F. (2022). Role of antimicrobial drug in the development of potential therapeutics. Evidence-Based Complementary and Alternative Medicine, 2022.
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Mar 5, 2024
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Pari Gul, Malik Ihsan Ullah Khan, Sadaf Ajmal, Shaista Anjum, Ayeesha Masood, & Kulsoom Baloch. (2024). BIOCHEMICAL EVALUATION OFVACCINIUM MACROCARPON AND EMBLICA OFFICINALIS IN ALLEVIATING ULCERATIVE COLITIS IN MICE . Journal of Population Therapeutics and Clinical Pharmacology, 31(3), 157-179. https://doi.org/10.53555/jptcp.v31i3.4790
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Author Biographies
Pari Gul
Institute of Biochemistry, University of Baluchistan, Pakistan.
Malik Ihsan Ullah Khan
Institute of Molecular Biology and Biotechnology, University of Lahore, Pakistan.
Sadaf Ajmal
Department of Genetics, University of Karachi, Pakistan.
Shaista Anjum
Department of Botany, University of Balochistan, Pakistan.
Ayeesha Masood
Department of Botany, University of Balochistan, Pakistan.
Kulsoom Baloch
Institute of Biochemistry, University Of Baluchistan, Pakistan.
How to Cite
Pari Gul, Malik Ihsan Ullah Khan, Sadaf Ajmal, Shaista Anjum, Ayeesha Masood, & Kulsoom Baloch. (2024). BIOCHEMICAL EVALUATION OFVACCINIUM MACROCARPON AND EMBLICA OFFICINALIS IN ALLEVIATING ULCERATIVE COLITIS IN MICE . Journal of Population Therapeutics and Clinical Pharmacology, 31(3), 157-179. https://doi.org/10.53555/jptcp.v31i3.4790