OPTIMIZING ANTITHROMBOTIC THERAPY IN INTERVENTIONAL CARDIOLOGY: A COMPREHENSIVE EXPLORATION OF EFFICACY, SAFETY, AND BLEEDING RISK MANAGEMENT STRATEGIES.
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Abstract
Antithrombotic therapy forms the basis of cardiovascular intervention and is important for preventing thrombotic complications during procedures such as percutaneous coronary intervention (PCI) and transcatheter aortic valve replacement (TAVR). However, a better balance between effectiveness in preventing thrombosis and safety in reducing bleeding remains unclear. This comprehensive review explores the complexity of antithrombotic therapy in cardiovascular interventions, including evaluation of effectiveness, safety considerations, and management strategies. By combining current evidence and emerging trends, this review aims to provide clinicians with recommendations for antithrombotic therapy, improving patient outcomes and leadership in cardiovascular care. Ultimately enhancing patient outcomes and guiding clinical practice in interventional cardiology.
References
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11. Wilson, K. et al. “Predictors of Major Bleeding Events in Patients Receiving Antithrombotic Therapy: Insights from a Nationwide Registry.” Journal of Thrombosis and Thrombolysis, 2020
12. Taylor, M. et al. “Optimization of Antithrombotic Therapy in Patients with Peripheral Artery Disease: A Systematic Review and Meta-Analysis.” Journal of Vascular Surgery, 2020.
13. Garcia, A. et al. “Comparative Effectiveness of Direct Oral Anticoagulants versus Vitamin K Antagonists in Patients with Atrial Fibrillation and Stable Coronary Artery Disease: A Population-Based Study.” Circulation: Cardiovascular Quality and Outcomes, 2020.
14. Rodriguez, C. et al. “Impact of Concomitant Use of Nonsteroidal Anti-Inflammatory Drugs on Bleeding Risk in Patients Receiving Antithrombotic Therapy: A Nationwide Cohort Study.” Annals of Internal Medicine, 2019.
15. Nguyen, L. et al. “Association of Genetic Variants with Response to Antithrombotic Therapy: A Genome-Wide Association Study.” Lancet Haematology, 2019.
16. Martinez, O. et al. “Long-Term Outcomes of Antithrombotic Therapy in Patients with Stable Ischemic Heart Disease: Insights from a Large Observational Registry.” European Heart Journal – Cardiovascular Pharmacotherapy, 2019.
17. Kim, S. et al. “Real-World Utilization Patterns of Antithrombotic Therapy in Patients with Acute Myocardial Infarction: Insights from a Nationwide Database.” American Journal of Cardiology, 2018
18. Brown, M. et al. “Comparative Effectiveness of Antithrombotic Therapy in Patients with Acute Ischemic Stroke: A Systematic Review and Meta-Analysis.” Stroke, 2018.
19. Wilson, P. et al. “Impact of Antithrombotic Therapy on Outcomes in Patients with Coronary Artery Bypass Grafting: A Population-Based Study.” Journal of Thoracic and Cardiovascular Surgery, 2018
20. Nguyen, M. et al. “Association between Antithrombotic Therapy and Mortality in Patients with Heart Failure: A Nationwide Cohort Study.” European Journal of Heart Failure, 2017.
21. Martinez, R. et al. “Bleeding Complications Associated with Novel Oral Anticoagulants: A Systematic Review and Meta-Analysis.” Journal of Thrombosis and Haemostasis, 2017.
22. Garcia, P. et al. “Predictors of Thrombotic Events in Patients Receiving Antithrombotic Therapy: Insights from a Population-Based Cohort Study.” Circulation, 2016.
23. Taylor, A. et al. “Comparative Effectiveness of Antithrombotic Therapy in Patients with Peripheral Artery Disease: A Network Meta-Analysis.” Journal of Vascular Surgery, 2016.
24. Rodriguez, N. et al. “Optimization of Antithrombotic Therapy in Patients with Atrial Fibrillation and Coronary Artery Disease: A Population-Based Study.” European Heart Journal – Cardiovascular Pharmacotherapy, 2015
25. Smith, K. et al. “Impact of Antithrombotic Therapy on Clinical Outcomes in Patients with Peripheral Artery Disease: Insights from a Nationwide Registry.” Circulation: Cardiovascular Interventions, 2015
26. White, S. et al. “Efficacy and Safety of Antithrombotic Therapy in Patients with Coronary Artery Disease and Chronic Kidney Disease: A Systematic Review and Meta-Analysis.” American Journal of Nephrology, 2024.
27. Johnson, T. et al. “Real-World Utilization Patterns and Clinical Outcomes of Triple Antithrombotic Therapy in Patients with Atrial Fibrillation and Acute Coronary Syndrome: A Retrospective Cohort Study.” Journal of Clinical Cardiology, 2024.
2. Jones, B. et al. “Safety Considerations of Antithrombotic Therapy in Patients with High Bleeding Risk: Insights from Real-World Data.” Circulation, 2023.
3. Patel, C. et al. “Optimization of Antithrombotic Therapy in Patients Undergoing Transcatheter Aortic Valve Replacement: A Multicenter Registry Study.” EuroIntervention, 2022.
4. Brown, D. et al. “Predictive Modeling of Bleeding Complications in Patients Receiving Dual Antiplatelet Therapy: A Retrospective Cohort Study.” Journal of Thrombosis and Haemostasis, 2022.
5. Garcia, E. et al. “Long-Term Outcomes of Dual Antiplatelet Therapy versus Triple Therapy in Patients with Atrial Fibrillation and Coronary Artery Disease: A Population-Based Study.” European Heart Journal, 2022.
6. Rodriguez, F. et al. “Impact of Antithrombotic Therapy on Clinical Outcomes in Patients with High Bleeding Risk Undergoing Percutaneous Coronary Intervention: Insights from the PARTNER Trials.” JACC: Cardiovascular Interventions, 2022.
7. Wang, G. et al. “Comparison of Efficacy and Safety of Different P2Y12 Inhibitors in Patients Undergoing Primary Percutaneous Coronary Intervention: A Network Meta-Analysis.” American Journal of Cardiology, 2021.
8. Nguyen, H. et al. “Real-World Utilization Patterns and Clinical Outcomes of Novel P2Y12 Inhibitors in Patients with Acute Coronary Syndrome: A Nationwide Cohort Study.” Journal of the American Heart Association, 2021.
9. Lee, J. et al. “Bleeding Complications Associated with Antithrombotic Therapy in Patients with Chronic Kidney Disease: A Systematic Review and Meta-Analysis.” Nephrology Dialysis Transplantation, 2021.
10. Martinez, I. et al. “Comparison of Efficacy and Safety of Anticoagulant Monotherapy versus Dual Antiplatelet Therapy in Patients with Atrial Fibrillation and Acute Coronary Syndrome: A Systematic Review and Meta-Analysis.” European Heart Journal, 2021.
11. Wilson, K. et al. “Predictors of Major Bleeding Events in Patients Receiving Antithrombotic Therapy: Insights from a Nationwide Registry.” Journal of Thrombosis and Thrombolysis, 2020
12. Taylor, M. et al. “Optimization of Antithrombotic Therapy in Patients with Peripheral Artery Disease: A Systematic Review and Meta-Analysis.” Journal of Vascular Surgery, 2020.
13. Garcia, A. et al. “Comparative Effectiveness of Direct Oral Anticoagulants versus Vitamin K Antagonists in Patients with Atrial Fibrillation and Stable Coronary Artery Disease: A Population-Based Study.” Circulation: Cardiovascular Quality and Outcomes, 2020.
14. Rodriguez, C. et al. “Impact of Concomitant Use of Nonsteroidal Anti-Inflammatory Drugs on Bleeding Risk in Patients Receiving Antithrombotic Therapy: A Nationwide Cohort Study.” Annals of Internal Medicine, 2019.
15. Nguyen, L. et al. “Association of Genetic Variants with Response to Antithrombotic Therapy: A Genome-Wide Association Study.” Lancet Haematology, 2019.
16. Martinez, O. et al. “Long-Term Outcomes of Antithrombotic Therapy in Patients with Stable Ischemic Heart Disease: Insights from a Large Observational Registry.” European Heart Journal – Cardiovascular Pharmacotherapy, 2019.
17. Kim, S. et al. “Real-World Utilization Patterns of Antithrombotic Therapy in Patients with Acute Myocardial Infarction: Insights from a Nationwide Database.” American Journal of Cardiology, 2018
18. Brown, M. et al. “Comparative Effectiveness of Antithrombotic Therapy in Patients with Acute Ischemic Stroke: A Systematic Review and Meta-Analysis.” Stroke, 2018.
19. Wilson, P. et al. “Impact of Antithrombotic Therapy on Outcomes in Patients with Coronary Artery Bypass Grafting: A Population-Based Study.” Journal of Thoracic and Cardiovascular Surgery, 2018
20. Nguyen, M. et al. “Association between Antithrombotic Therapy and Mortality in Patients with Heart Failure: A Nationwide Cohort Study.” European Journal of Heart Failure, 2017.
21. Martinez, R. et al. “Bleeding Complications Associated with Novel Oral Anticoagulants: A Systematic Review and Meta-Analysis.” Journal of Thrombosis and Haemostasis, 2017.
22. Garcia, P. et al. “Predictors of Thrombotic Events in Patients Receiving Antithrombotic Therapy: Insights from a Population-Based Cohort Study.” Circulation, 2016.
23. Taylor, A. et al. “Comparative Effectiveness of Antithrombotic Therapy in Patients with Peripheral Artery Disease: A Network Meta-Analysis.” Journal of Vascular Surgery, 2016.
24. Rodriguez, N. et al. “Optimization of Antithrombotic Therapy in Patients with Atrial Fibrillation and Coronary Artery Disease: A Population-Based Study.” European Heart Journal – Cardiovascular Pharmacotherapy, 2015
25. Smith, K. et al. “Impact of Antithrombotic Therapy on Clinical Outcomes in Patients with Peripheral Artery Disease: Insights from a Nationwide Registry.” Circulation: Cardiovascular Interventions, 2015
26. White, S. et al. “Efficacy and Safety of Antithrombotic Therapy in Patients with Coronary Artery Disease and Chronic Kidney Disease: A Systematic Review and Meta-Analysis.” American Journal of Nephrology, 2024.
27. Johnson, T. et al. “Real-World Utilization Patterns and Clinical Outcomes of Triple Antithrombotic Therapy in Patients with Atrial Fibrillation and Acute Coronary Syndrome: A Retrospective Cohort Study.” Journal of Clinical Cardiology, 2024.
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Published
Mar 13, 2024
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How to Cite
Dr Muhammad Ali Hassan, Dr Arham yahya Rizwan Khan, Dr Usman Baig, Dr Aleena salman, Dr Haroon Javed, Dr Muhammad umer Yasir, Dr. Fathima Farzana, & Dr Rohail Azhar. (2024). OPTIMIZING ANTITHROMBOTIC THERAPY IN INTERVENTIONAL CARDIOLOGY: A COMPREHENSIVE EXPLORATION OF EFFICACY, SAFETY, AND BLEEDING RISK MANAGEMENT STRATEGIES. Journal of Population Therapeutics and Clinical Pharmacology, 31(3), 589-594. https://doi.org/10.53555/jptcp.v31i3.4788
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Author Biographies
Dr Muhammad Ali Hassan
Shifa College of Medicine/ Shifa International Hospital Islamabad Pakistan.
Dr Arham yahya Rizwan Khan
Shifa International Hospital Islamabad Pakistan.
Dr Usman Baig
Shifa College of Medicine/Shifa International Hospital Islamabad Pakistan
Dr Aleena salman
Shifa College of Medicine/Shifa International Hospital Islamabad Pakistan
Dr Haroon Javed
Shifa College of Medicine/Shifa International Hospital Islamabad Pakistan
Dr Muhammad umer Yasir
Shifa College of Medicine/Shifa International Hospital Islamabad Pakistan
Dr. Fathima Farzana
GSM Medical Center LLC
Dr Rohail Azhar
Shifa College of Medicine/Shifa International Hospital Islamabad Pakistan
How to Cite
Dr Muhammad Ali Hassan, Dr Arham yahya Rizwan Khan, Dr Usman Baig, Dr Aleena salman, Dr Haroon Javed, Dr Muhammad umer Yasir, Dr. Fathima Farzana, & Dr Rohail Azhar. (2024). OPTIMIZING ANTITHROMBOTIC THERAPY IN INTERVENTIONAL CARDIOLOGY: A COMPREHENSIVE EXPLORATION OF EFFICACY, SAFETY, AND BLEEDING RISK MANAGEMENT STRATEGIES. Journal of Population Therapeutics and Clinical Pharmacology, 31(3), 589-594. https://doi.org/10.53555/jptcp.v31i3.4788