AEFI (ADVERSE EVENTS FOLLOWING IMMUNIZATION) AMONG CHILDREN LESS THAN 2 YEARS FOLLOWING PENTAVALENT VACCINE– A CROSS-SECTIONAL STUDY IN INDIA
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Keywords
Vaccination, Immunization, Adverse Events Following Immunization, pentavalent vaccine, AEFI
Abstract
Introduction: Despite significant progress in vaccine-preventable disease control, Immunization is not free of controversies. Vaccine safety is increasingly becoming important because of alleged safety issues that can derail vaccine programs worldwide.
Aims: To study AEFI (Adverse Events Following Immunization) following the Pentavalent vaccine among children under two years old getting immunized at the session site.
Methods and Material: The study was a population-based cross-sectional study. A total of 209 children got vaccinated at the selected sub-centers for one year. The investigator contacted the mothers of the vaccinated children through two home visits. A pre-designed, pre-tested, semi-structured schedule was used to gather data. Categorical data was presented as a percentage (%). The descriptive analysis of data was depicted in graphs and percentages after statistical analysis.
Results: It was observed that AEFI incidence rate per 1000 doses was higher following the first dose of pentavalent vaccine (312.05), followed by the second dose (290.78) and third dose (271.42), fever [31.3% (1st dose), 29.1% (2nd dose), 27.1% (3rd dose)] was the most common AEFI observed. All the mothers (100%) were told that the vaccine was responsible for the occurrence of AEFI in their children and wished to continue vaccinating their children for further doses.
Conclusion: All the AEFI observed were minor. The benefits of vaccines outweighed the AEFI observed, as the mothers were willing to continue vaccinating their children even after the occurrence of AEFI.
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Pragya Dixit MD
Medical Officer, ESI Health Care Haryana, Panipat, HR, INDIA
Praveen Prashant MD
Senior Resident/Demonstrator, Department of Biochemistry, Pt. B D Sharma PGIMS, Rohtak, HR, INDIA
Vivek Gera MD
Medical Officer, Haryana Civil Medical Services, Rohtak, HR, INDIA.
Abhishek Bansal MSc
Senior Resident/Demonstrator, Department of Biochemistry, Pt. B D Sharma PGIMS, Rohtak, HR, INDIA