MICROPERIMETRIC SENSITIVITY IN PATIENTS ON HYDROXYCHLOROQUINE (PLAQUENIL) THERAPY‏

Main Article Content

Ahmad Mohammad Albogami
Zakaria Ali Alobaidi
Abdullah Abdulmohsen Alotaibi
Mnwer Khlaiwi Alalasi
Eyad Ahmed Althagafi
Tahreer Ahmed Saleh Al Habeeb

Keywords

Hydroxychloroquine, Plaquenil, Microperimetry, Retinal Toxicity, Autoimmune Diseases

Abstract

Hydroxychloroquine (Plenil) therapy is commonly used in the treatment of various autoimmune diseases, such as lupus and rheumatoid arthritis. One of the side effects of hydrochloroquine therapy is retinal toxicity, which can lead to irreversible vision loss if not detected early. Microperimetry has proven to be a valuable tool in assessing retinal sensitivity in patients on hydroxychloroquine therapy. This essay aims to investigate the microperimetric sensitivity in patients on hydroxychloroquine therapy, exploring the methods used, results obtained, and implications for clinical practice.

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References

1. Marmor MF, Kellner U, Lai TY, Lyons JS, Mieler WF. Revised recommendations on screening for chloroquine and hydroxychloroquine retinopathy. Ophthalmology. 2011;118(2):415-422.
2. Marmor MF, Hu J. Effect of disease stage on progression of hydroxychloroquine retinopathy. JAMA Ophthalmology. 2014;132(10):1215-1220.
3. Lai TY, Chan WM, Lai RY, et al. Visual field and multifocal electroretinography and their correlations in patients on hydroxychloroquine therapy. Documenta Ophthalmologica. 2006;113(3):187-197.
4. Yusuf IH, Sharma S, Luqmani R, Downes SM. Hydroxychloroquine retinopathy. Eye. 2017;31(6):828-845.
5. Amirah U, Yusoff PNM, Mohamad M, et al. Progression of retinal toxicity with hydroxychloroquine: a follow-up study using Humphrey visual field analysis. International Journal of Ophthalmology. 2017;10(9):1415-1420.
6. Mititelu M, Wong BJ, Brenner M, Bryar PJ, Jampol LM, Fawzi AA. Progression of hydroxychloroquine toxic effects after drug therapy cessation: new evidence from multimodal imaging. JAMA Ophthalmology. 2013;131(9):1187-1197.
7. Browning DJ, Lee C. The relative sensitivity and specificity of 10-2 visual fields, multifocal electroretinography, and spectral domain optical coherence tomography in detecting hydroxychloroquine and chloroquine retinopathy. Clinical Ophthalmology. 2014;8:1389-1399.
8. Aristodemou P, Aboshiha J, Athanasiou D, et al. High-resolution spectral domain optical coherence tomography imaging of retinal changes in hydroxychloroquine toxicity. Ophthalmic Surgery, Lasers, and Imaging Retina. 2013;44(3):187-189.
9. Melles RB, Marmor MF. The risk of toxic retinopathy in patients on long-term hydroxychloroquine therapy. JAMA Ophthalmology. 2014;132(12):1453-1460.
10. Kliś K, Janiszewska J, Słowińska M, Modrzejewska M. Evaluation of retinal sensitivity in patients treated with hydroxychloroquine: a case series. Current Issues in Ophthalmology. 2018;29(1):37-45.

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