NOVEL Plumbago Indica L. EXTRACT HERBOSOMES: DEVELOPMENT AND OPTIMIZATION USING EXPERIMENTAL DESIGN
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Keywords
Efficacy, Herbosome, In-vitro studies, Plumbago Indica L, soyalecithin
Abstract
Aim: This study was to develop and evaluate a novel herbosome formulation of Plumbago Indica L. Root Extract with phospholipid.
Methods: The impact of many methods and formulation factors was examined in order to synthesize the Herbosome-loaded Plumbago Indica L. roots extract. The technique of thin-film hydration was utilized, with soya-lecithin serving as the phospholipid of choice. The Plumbagin herbosome was confirmed by taking into account a number of factors, including as particle size, zeta-potential, scanning electron microscopy and entrapment efficiency (%) compared with drug.
Results: The optimized technique provided that particle size within the range and good polydispersity index, an average Zeta potential of -45.3 mV, and an entrapment efficacy (%) of 69.42. Shape and morphology analysis using a scanning electron microscope revealed a smooth surface and spherical shape. The formulation adheres to the zero order kinetic models based on the greatest correlation (R2) value, as evidenced by further in-vitro drug release studies of the improved formulation.
Conclusion: Formulation research aims to develop a dosage form that is elegant, reliable, safe, and compatible with other components. The herbosomal complex was observed better solubility, melting point. In-vitro studies for hepatic malignancy were conducted to further confirm the efficacy of the optimized formulation.
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Hemant Bhatia
Research Scholar, Faculty of Pharmaceutical Sciences, Jayoti Vidyapeeth Women’s University,
Jaipur – 303122, Rajasthan, INDIA
Dharmendra Ahuja
Dean & Director, Faculty of Pharmaceutical Sciences, Jayoti Vidyapeeth Women’s University, Jaipur – 303122, Rajasthan, INDIA