ANTI-MULLERIAN HORMONE AND INHIBIN B AS A DIAGNOSTIC REPLACEMENT OF HUMAN CHORIONIC GONADOTROPIN STIMULATION TEST IN EVALUATION OF 46 XY DISORDERS OF SEX DEVELOPMENT
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Keywords
46 XY DSD, inhibin B, anti-Mullerian hormone (AMH), testosterone
Abstract
Background: As blood anti-Müllerian hormone (AMH) measurement may assess male gonad function without the need of invasive dynamic testing, it is becoming more and more common. A measurement of inhibin B may be thought of as a diagnosis tool that provides accurate data regarding the existence and functionality of the tests.
Objective: To assess the role of AMH and inhibin-B in diagnosis of 46, XY disorders of sex development (DSD) in comparison to HCG stimulation test.
Patients and methods: 42 individuals with 46 XY DSD were the subject of the research, which also included 42 healthy male participants from DEMPU, New Pediatric Hospital, and Cairo University. The analyzed patients had a 4 year average age.
Results: there was a statistically considerable variation between level of AMH in testicular agenesis/dysgenesis and 46 XY DSD group (p˂0.001). Basal AMH and HCG-activated testosterone and DHT showed a substantial connection. Inhibin B, HCG-stimulated testosterone, and DHT were not shown to be substantially connected with one another. At a cut-off value of (43.2ng/ml), the sensitivity of AMH was (90.9%), specificity (96.8%), NPV (90.91%) PPV (96.77%), with overall accuracy (95.24%) to determine if functioning testicular tissue is present. While the inhibin B showed no discrimination between subjects who had functioning testicular tissue from those who had not.
Conclusion: AMH is valuable reliable non-invasive parameter for identifying functional testicular tissue in 46 XY DSD patients.
References
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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Fatma Ahmed Fathi Elmougy
Department of chemical pathology, Kasr alaini hospital, Cairo university
Mona Hassan Hafez
Department of chemical pathology, Kasr alaini hospital, Cairo university
Reham Assem AlEssawy
Department of chemical pathology, Kasr alaini hospital, Cairo university
Soha Hamed Ammar Abd-Elhaleem
Department of chemical pathology, Kasr alaini hospital, Cairo university
Hend M. Soliman
Department of chemical pathology, Kasr alaini hospital, Cairo university
Rania Essam Ali Gamal Eldin
Department of chemical pathology, Kasr alaini hospital, Cairo university