PROGRAMMED DEATH- LIGAND 1 EXPRESSION IN UROTHELIAL CARCINOMA
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Keywords
urothelial bladder carcinoma, glandular, histopathological
Abstract
Background :Urothelial bladder cancer is a disease of significant morbidity and mortality. It is ninth most common malignancy worldwide. It is the 7th most common cancer worldwide in men and the 17th most common cancer worldwide in women. Methods: The present study was undertaken in the Department of Pathology, after getting approval from Institutional Ethical Committee . Samples were collected from the department of urology with their clinical details. The study design was Retrospective and Prospective Cross-sectional study. Results: Majority of the cases were Conventional UC (83.8%), other common types were Squamoid, Glandular and Signet ring (5.0%, 6.3% & 2.5%). Apart from these, 1 (1.3%) case each was differentiated as Sarcomatoid and Sarcomatoid with glandular variant. Conclusions: Majority of cases with tumour recurrence showed strong positive PD-L1 expression and this association was found to be significant suggesting that degree of PD-L1 expression may be a crucial determinant of tumour invasiveness not only for primary tumours but also for recurrent tumours.
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Dr Nidhi Pagia
Asisstant Professor, Department Of Pathology, Rama Medical College Hospital And Research Center, Hapur
Dr Ritu Saxena
Asisstant Professor, Department Of Pathology, Rama Medical College Hospital And Research Center , Hapur