EFFECTS OF MAGNESIUM SUPPLEMENTATION ON ANTI-MULLERIAN HORMONE LEVEL IN PREMENOPAUSAL WOMEN
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Keywords
Fertility, anti-müllerian hormone, Follicles, Magnesium, Premenopausal
Abstract
In human females, fertility is closely linked to anti-müllerian hormone (AMH) levels. As women age, the number of follicles in their ovaries decreases, as a result their AMH levels decline. This decrease in AMH levels is associated with a decrease in fertility, and a higher risk of infertility and pregnancy complications. Magnesium supplementation has been suggested to positively affect the AMH level in women serum. The study aimed to investigate whether oral magnesium supplementation is positively or negatively correlated with the serum levels of AMH among premenopausal females. The study involved 26 females, including 13 normal fertile females (control group) and 13 infertile females (experimental group). The experimental group was further divided into pre-supplement and post-supplement groups, and given magnesium supplementation (Nutrifactor 500 mg) at regular intervals for 4 weeks. The results showed a significant increase in AMH levels in the post-supplement group compared to the pre-supplement group. The findings suggest that magnesium supplementation can enhance AMH levels, which are responsible for follicle recruitment and fertility. This finding is particularly relevant for assisted reproductive techniques, like in-vitro fertilization (IVF) and intra-cytoplasmic sperm injection (ICSI), where AMH levels are critical for success.
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Rabia Sundas
Department of Zoology, University of Sialkot, Punjab, Pakistan
Rabea Ejaz
Department of Zoology, Rawalpindi Women University, Rawalpindi-46300 Pakistan
Saleha Ashfaq
Department of Biology, University of Haripur, Haripur-22620, Khyber Kakhtunkhwa, Pakistan
Saima Qadeer
Department of Zoology, Division of Sciences and Technology, University of Education, Lahore-54000 Pakistan.
Asima Azam
Department of Zoology, Shaheed Benazir Bhutto Women University, Peshawar-25000 Pakistan
Wajeeha Saeed
Department of Biology, University of Haripur, Haripur-22620, Khyber Kakhtunkhwa, Pakistan
Naqash Khan
Department of Biology, University of Haripur, Haripur-22620, Khyber Kakhtunkhwa, Pakistan
Rukshanda Saleem
Department of Zoology, University of Sialkot, Punjab, Pakistan
Asma Ul Husna
Department of Biology, University of Haripur, Haripur-22620, Khyber Kakhtunkhwa, Pakistan