Anti-Leishmaniasis, Anti-Urease, Anti-Bacterial and Anti-Oxidant Activities Of Β-Hydroxy Keto Compounds Synthesized Through Aldol Reaction
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Keywords
Synthesis, Aldol, Anti-urease, Anti- fungal, Anti-bacterial, anti-leishmaniasis.
Abstract
Aldol and its derivatives play crucial role in the field of biological research. Recently, Numerous pharmacological investigations on aldol and its compounds have been carried out. However, more research is needed to determine the significance of biological compounds. “The β-hydroxy carbonyl compound is the central core for different necessity of biological compounds. The β-hydroxy carbonyl compounds are synthesized by an aldol reaction of Cyclohexanone with 2- bromo, 3-bromo, 4-bromo benzaldehydes in the presence of a catalyst (2-picolylamine) and solvent (water & ethanol) gives a compound. Different biological studies were carried out of the synthesized compound, such as anti- bacterial, anti-fungal, anti-leishmaniasis, anti-urease. Among different substituted compounds some were found with few folds’ better potentials than standard drug E. coli, Terbinafine, thiourea and paromomycin.
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Muhammad Shoaib
Department of Chemistry, University of Malakand, Chakdara Dir Lower, KPK, 18800, Pakistan.
Muhammad Naveed Umar
Department of Chemistry, University of Liverpool, UK.
Muhammad Zahoor
a:1:{s:5:"en_US";s:23:"University of Malakand ";}
Sher Wali Khan
Department of chemistry, the Rawalpindi women university, 6th road satellite town Rawalpindi-Pakistan
Riaz Ullah
Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
Essam A. Ali
Department of Pharmaceutical Chemistry, College of Pharmacy King Saud University Riyadh Saudi Arabia
Naila Gulfam
Department of Zoology, Jinnah College for Women, University of Peshawar Khyber Pakhtunkhwa Province, Pakistan