CORRELATION OF GENOTYPES, ANTIVIRAL DRUGS, GENDER AND AGE DIFFERENCES IN OLD AGED HCV PATIENTS OF SIALKOT, PAKISTAN
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Keywords
Hepatitis C virus, genotype 3, direct-acting antiviral drugs, age, gender
Abstract
The Hepatitis C virus contains RNA as its genome that can cause liver injury at the cellular level. Inflammation caused by viruses can progress to lethal conditions such as fibrosis, cirrhosis and cancer. Various direct-acting anti-viral drugs are available in the market in many regions of the world. These drugs work on principle by targeting specific proteins which damage the virus. Many drugs are administered in combination and produce a sustained virological response in 12 weeks. A follow-up research was performed to evaluate 3 months of treatment outcome of some direct-acting antiviral drugs in 131 patients (110 patients of HCV genotype 3) above 50 years and they were compared related to type of genotypes, administration of antiviral drugs, gender and age differences. 115 patients yielded a pooled SVR of more than 85% after twelve weeks of commonly used antiviral drug evaluation. Commonly used antiviral drugs in Sialkot, Pakistan, showed effectiveness in HCV patients having genotypes 1-5.
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Kashif Waqas
Centre of Research in Molecular Medicine, Institute of Molecular Biology and Biotechnology, The University of Lahore - Pakistan
Syed Zeeshan Haider Naqvi
Centre of Research in Molecular Medicine, Institute of Molecular Biology and Biotechnology, The University of Lahore - Pakistan
Muhammad Usama Arshad
International Higher School of Medicine, Bishkek - Kyrgyzstan
Usama Basirat
Radiology Research Section (DMRD), The University of Lahore - Pakistan
Javed Anver Qureshi
Centre of Research in Molecular Medicine, Institute of Molecular Biology and Biotechnology, The University of Lahore - Pakistan
Sabira Sultana
Department of Eastern Medicine, Faculty of Medical Sciences, Government College University Faisalabad - Pakistan
Faheem Hadi
Faculty of Medicine and Allied Health Sciences, The Islamia University of Bahawalpur - Pakistan.
Qurban Ali
University of the Punjab, Lahore - Pakistan