STUDY OF CHANGES IN BIOLOGICAL AND HEAMOTOLOGICAL MARKERS IN PAKISTANI PATIENTS OF AGES ABOVE 50 YEARS WITH CHRONIC HEPATITIS C GENOTYPES 1-5 IN THE ERA OF DIRECT ACTING ANTIVIRAL DRUGS
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Keywords
Hepatitis C virus, genotype 3, direct-acting antiviral drugs, liver function tests, renal function tests
Abstract
The Hepatitis C virus is RNA containing virus which damages liver at molecular level and causes inflammatory conditions such as fibrosis and cirrhosis and can also lead to cancer. Various direct-acting anti-viral drugs available in local area were administered to patients. These drugs work on principle by targeting specific proteins which damage the virus. Many drugs are administered in combination and produce a sustained virological response in 12 weeks. A follow-up research was performed to evaluate 3 months of treatment outcome of some direct-acting antiviral drugs in 131 patients (110 patients of HCV genotype 3) above 50 years using relevant biological parameters. 115 patients yielded a pooled SVR of more than 85% after twelve weeks of commonly used antiviral drug evaluation. Commonly used antiviral drugs in Sialkot, Pakistan, showed effectiveness in HCV patients having genotypes 1-5 as evidenced by biological and haemotological markers.
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Kashif Waqas
Centre of Research in Molecular Medicine, Institute of Molecular Biology and Biotechnology, The University of Lahore - Pakistan
Syed Zeeshan Haider Naqvi
Centre of Research in Molecular Medicine, Institute of Molecular Biology and Biotechnology, The University of Lahore, Lahore, Pakistan.
Usama Basirat
Radiology Research Section (DMRD), The University of Lahore - Pakistan
Muhammad Usama Arshad
International Higher School of Medicine, Bishkek - Kyrgyzstan
Javed Anver Qureshi
Centre of Research in Molecular Medicine, Institute of Molecular Biology and Biotechnology, The University of Lahore - Pakistan
Sabira Sultana
Department of Eastern Medicine, Faculty of Medical Sciences, Government College University Faisalabad - Pakistan
Faheem Hadi
Faculty of Medicine and Allied Health Sciences, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.