A REVIEW ON PLANT PRODUCTS AS MULTIPLE EFFECT ON OPHTHALMIC DERMATOLOGY

Main Article Content

Neha Patel
Ms. Foram Mehta
Dr. Pragnesh Patani

Keywords

herbal remedies, ophthalmic dermatology, periorbital hyperpigmentation, eyelid eczema, natural interventions

Abstract

Ophthalmic dermatology encompasses a diverse array of conditions affecting the delicate and sensitive skin around the eyes. The conventional management of such conditions often involves pharmaceutical interventions that may be associated with adverse effects. As an alternative approach, herbal remedies have gained attention for their potential multifaceted benefits in addressing various ophthalmic dermatological concerns. This review aims to consolidate current knowledge on the multiple effects of plant products used in the context of ophthalmic dermatology.


Through a comprehensive literature search, this review identifies and analyzes plants interventions that have shown promise in the management of conditions such as periorbital hyperpigmentation, eyelid eczema, dry skin around the eyes, and under-eye bags. The multifaceted effects of these plants include antioxidant, anti-inflammatory, anti-aging, moisturizing, and skin-lightening properties. Various bioactive compounds present in these plants, such as polyphenols, flavonoids, and essential oils, contribute to their therapeutic effects.


Furthermore, the review examines the safety and efficacy profiles of these plants  interventions, taking into consideration potential adverse reactions and interactions. The integration of traditional wisdom, empirical evidence, and modern scientific studies provides a holistic perspective on the utilization of plants in ophthalmic dermatology.


In conclusion, herbal interventions offer a promising avenue for individuals seeking a more natural and holistic approach to managing ophthalmic dermatological conditions. However, further research is warranted to elucidate the mechanisms of action, optimize formulation techniques, and validate the clinical efficacy of these plans. A collaborative effort between traditional herbal medicine practitioners and modern dermatologists could potentially lead to the development of evidence-based plants interventions that complement conventional therapeutic strategies for ophthalmic dermatology

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References

1. Abdul L, Abdul R, Sukul RR, Nazish S. Anti-inflammatory and antihistaminic study of a Unani eye drop formulation. Ophthalmic Eye Dis. 2010; 10:17–22.
2. Agarwal R, Gupta SK, Agarwal SS, Srivastava S, Saxena R. Oculohypotensive effects of Foeniculum vulgare in experimental models of glaucoma. Indian J Physio Pharmocol. 2008; 52:77–83.
3. Akbari A, Nasiri K, Heydari M. Ginger (Zingiber officinale Roscoe) extract can improve the levels of some trace element and total homocysteine and prevent oxidative damage induced by ethanol in rat eye. Avicenna J Phytomer. 2020; 10:365–371.
4. Babbar OP, Chatwal VK, Ray IB. Effect of berberine chloride eye drops on clinically positive trachoma patients. Ind J Med Res. 1982; 76:83–88.
5. Bajpai A, Nainwal RC, Singh D. Coptis teeta: a potential endemic and endangered medicinal plant of Eastern Himalayas. J Pharmacogn Phytochem. 2019; 8:245–248.
6. Barathi VA, Beuerman RW. Molecular mechanisms of muscarinic receptors in mouse scleral fibroblasts: Prior to and after induction of experimental myopia with atropine treatment. Mol Vis. 2011; 17:680–691.
7. Bhatia M, Siddiqui NA, Gupta SA. Abrus precatorius: an evaluation of traditional herb. Indo American Journal of Pharm Research. 2013; 3:3295–3315.
8. Bonyadi MHJ, Yazdani S, Saadat S. The ocular hypotensive effect of saffron extract in primary open angle glaucoma: a pilot study. BMC Complement Altern Med. 2014; 15:399.
9. Broadhead GK, Grigg JR, McCluskey P, Hong T, Schlub TE, Chang AA. Saffron therapy for the treatment of mild/ moderate age-related macular degeneration: a randomized clinical trial. Graefes Arch Clin Exp Ophthalmol. 2019; 257:31–40.
10. Chia A, Lu QS, Tan D. Five-year clinical trial on atropine for the treatment of myopia 2: myopia control with atropine 0. 01% eyedrops. Ophthalmology. 2016; 123:391–399.
11. Dhanik J, Arya N, Nand V. A review on Zingiber officinale. J Pharmacogn Phytochem. 2017; 6:174–184.
12. Dongare S, Gupta SK, Mathur R, Saxena R, Mathur S, Agarwal R, Nag TC, Srivastava S, Kumar P. Zingiber officinale attenuates retinal microvascular changes in diabetic rats via anti-inflammatory and antiangiogenic mechanisms. Mol Vis. 2016; 22:599–609.
13. Duncan G, Collison DJ. Role of the non-neuronal cholinergic system in the eye: a review. Life Sci. 2003; 72:2013–2019.
14. Eckert A, Keil U, Scherping I, Hauptmann S, Muller WE. Stabilization of mitochondrial membrane potential and improvement of neuronal energy metabolism by Ginkgo biloba extract EGb 761. Ann N Y Acad Sci. 2005; 1056:474–485.
15. Guo X, Kong X, Huang R, Jin L, Ding X, He M, Liu X, Chimanlal Patel M, Congdon N. Effect of Ginkgo biloba on visual field and contrast sensitivity in Chinese patients with normal tension glaucoma: a randomized, crossover clinical trial. Invest Ophthalmol Vis Sci. 2014; 55:110–116.
16. Hassan OA, Abu-Raghif AR, Rasheed AM, Al-Yawer MA. Effect of Foeniculum vulgare seed aqueous extract eye drops on selenite induced cataract in rabbits. Int J Pharm Sci Rev Res. 2017; 47:83–87.
17. Heitmar R, Brown J, Kyrou I. Saffron (Crocus sativus L) in ocular diseases: a narrative review of the existing evidence from clinical studies. Nutrients. 2019; 11:649.
18. Hosseini A, Razavi BM, Hosseinzadeh H. Saffron (Crocus sativus) petal as a new pharmacological target: a review. Iran J Basic Med Sci. 2018; 21:1091–1099.
19. Ige M, Liu J. Herbal medicines in glaucoma treatment. Yale J Biol Med. 2020; 93:347–353.
20. Jiang-Yan Li, Xiao-Bing Wang, Jian-Guang Luo, Ling-Yi Kong. Seasonal variation of alkaloid contents and anti-inflammatory activity of Rhizoma coptidis based on fingerprints combined with chemometrics methods. J Chromatogr Sci. 2015;53:1131–1139.
21. José Bagur M, Alonso Salinas GL, Jiménez-Monreal AM, Chaouqi S, Llorens S, Martínez-Tomé M, Alonso GL. Saffron: an old medicinal plant and a potential novel functional food. Molecules. 2017;23
22. Lind GJ, Chew SJ, Marzani D, Wallman J. Muscarinic acetylcholine receptor antagonists inhibit chick scleral chondrocytes. Invest Ophthalmol Vis Sci. 1998; 39:2217–2231.
23. Lone TA, Rahul M, Lone RA. In vitro anti-oxidant studies by using different methods and evaluation of anti-microbial potential of Coptis teeta. Global J Biotech & Biochem. 2014; 9:99–104.
24. Newman DJ, Cragg GM. Natural products as sources of new drugs from 1981 to 2014. J Nat Prod. 2016; 79:629–661.
25. Niazi Mashhadi Z, Irani M, Kiyani Mask M, Methie C. A systematic review of clinical trials on Ginkgo (Ginkgo biloba) effectiveness on sexual function and its safety. Avicenna J Phytomed. 2021; 11:324–331.
26. Mahmoudi Z, Soleimani M, Saidi A, Khamisipour G, Azizsoltani A. Effects of Foeniculum vulgare ethanol extract on osteogenesis in human mesenchymal stem cells. Avicenna J Phytomed. 2013; 3:135–137.
27. Miguel MG, Cruz C, Faleiro L, Simões M, Figueiredo AC, Barroso JG, Pedro LG. Foeniculum vulgare essential oils: chemical composition, antioxidant and antimicrobial activities. Nat Prod Commun. 2010; 5:319–328.
28. Mirzaei M, Gupta VB, Chick JM, Greco TM, Wu Y, Chitranshi N, Vander Wall R, Hone E, Deng L, Dheer Y, Abbasi M, Rezaeian M, Braidy N, You Y, Hosseini Salekdeh G, Haynes P, Molloy M, Martins R, Cristea I, Gygi S, Graham S, Gupta V. Age-related neurodegenerative disease associated pathways identified in retinal and vitreous proteome from human glaucoma eyes. Sci Rep. 2017;7
29. Mousavi SZ, Bathaie SZ. Historical uses of saffron: Identifying potential new avenues for modern research. Avicenna J Phytomed. 2011; 1:57–66.
30. Park JW, Kwon HJ, Chung WS, Kim CY, Seong GJ. Short term effects of Ginkgo biloba extract on peripapillary retinal blood flow in normal tension glaucoma. Korean J Ophthalmol. 2011; 25:323–328.
31. Pathan AH, Ali SA. Antiglaucoma activity of aqueous methanolic Zingiber officinale extract on carbomer induced glaucoma in rabbits. J Nat Remedies. 2014; 14:193–198.
32. Payum T. Distribution, ethnobotany, pharmacognosy and phytoconstituents of Coptis teeta Wal a highly valued and threatened medicinal plant of Eastern Himalayas. Pharmacog J. 2017; 9:28–34.
33. Prabha PM, Perumal C, Kumar MP, Sampath KR. Pharmacological activities of Abrus precatorius (L) seeds. Int J Pharm Med Res. 2015; 3:195–200.
34. Pinheiro GKLO, Filho IA, Neto IA, Rego ACM, Azevedo EP, Pinheiro FI, Filho AAS Nature as a source of drugs for ophthalmology. Arq Bras Oftalmol. 2018; 81:443–454.
35. Pooja Lal VK, Verma A. A review on Ayurvedic medicinal plants for eye disorders from ancient to modern era. Int J Pharm Sci Res. 2014; 5:5088–5096.
36. Rather MA, Dar BA, Sofi SN, Bhat BA, Qureshi MA. Foeniculum vulgare: A comprehensive review of its traditional use, phytochemistry, pharmacology, and safety. Arab J Chem. 2012; 9:1574–1583.
37. Rahimi R, Ardekani MRS. Medicinal properties of Foeniculum vulgare Mill in traditional Iranian medicine and modern phytotherapy. Chin J Integr Med. 2013; 19:73–79.
38. Ruetsch YA, Boni T, Borgeat A. From cocaine to ropivacaine: The history of local anaesthetic drugs. Curr Top Med Chem. 2001; 1:175–182.
39. Sari MD, Sihotang AD, Lelo A. Ginkgo biloba extract effect on oxidative stress marker malondialdehyde, redox enzyme glutathione peroxidase, visual field damage, and retinal nerve fibre layer thickness in primary open angle glaucoma. Int J Pharmtech Res. 2016; 9:158–166.
40. Sepahi S, Mohajeri SA, Hosseini SM, Khodaverdi E, Shoeibi N, Namdari M, Tabassi SAS. Effects of crocin on diabetic maculopathy: a placebo-controlled randomized clinical trial. Am J Ophthalmol. 2018; 190:89–98.
41. Shim SH, Kim JM, Choi CY, Kim CY, Park KH. Ginkgo biloba extract and bilberry anthocyanins improve visual function in patients with normal tension glaucoma. J Med Food. 2012; 15:818–823
42. Srikanth N, Haripriya N, Rath C, Bharti, Khanduri S, Padhi MM, Kumar A. Medicinal plants in eye care and exploration of their therapeutic potential: evidence based translational approach in: Kumar A, Padhi MM, Srikanth N, Dhar BP, Mangal AK (Eds), Conservation, cultivation and exploration of therapeutic potential of medicinal plants, Council for research in ayurvedic Sciences, Department of AYUSH, Ministry of Health & Family Welfare. New Delhi; 2014. pp. 359–374.
43. Srikanth N, Bansal P, Kaur J. An insight into indigenous ophthalmic medicine plant drugs; a scientific approach. DJO. 2007; 12:55–59.
44. Uma Maheswari M, Dhinesh S, Kumar KA, Subhadradevi TSV, Puliyath J Madeswaran A. Antic ataractic and antioxidant activities of Abrus precatorius Linn against calcium-induced cataractogenesis using goat lenses. Euro J Exp Bio. 2012; 2:378–384.
45. Uzodike EB, Ilodibe EC. Effect of ingested raw ginger Zingiber officinale on tear production. JNOA. 2010; 16:26–28.
46. Wagner H. Natural products chemistry and phytomedicine research in the new millennium: new developments and challenges. ARKIVOC. 2004; 7:277–284.