DARKSIDE OF NUTRACEUTICALS

Main Article Content

Mansi Makwana
Nirav Rathi
Dr. Pragnesh Patani

Keywords

.

Abstract

The concept of "Let food be your medicine and medicine be your food," attributed to Hippocrates, has resonated through the ages, emphasizing the therapeutic potential of food. This philosophy finds parallels in Ayurveda and culminated in the term "nutraceutical," coined by Dr. Stephen De Felice in 1989. Nutraceuticals, a fusion of "nutrition" and "pharmaceuticals," encompass substances from food with perceived health benefits.


This paper presents a comprehensive classification of nutraceuticals based on chemical composition, source, and traditional or nontraditional nature. It explores their popularity, safety concerns, and the misconception that "all-natural remedies are beneficial." The list of marketed nutraceuticals illustrates their diversity, from appetite suppressants to immune boosters.


The analysis delves into potential health risks associated with nutraceuticals, focusing on vitamins, minerals, omega-3 fatty acids, soy protein, and botanicals. Adverse incidents, including liver damage and birth defects, are discussed. The paper highlights the lack of scientific consensus on the effectiveness of nutraceuticals in preventing diseases.


Specific attention is given to contaminants such as heavy metals, pyrrolizidine alkaloids, and mycotoxins found in nutraceuticals, emphasizing their potential harm. The significance of understanding and regulating nutraceuticals is underscored, given their increasing prevalence and the need for consumer awareness.


In conclusion, while nutraceuticals offer potential health benefits, their safety and efficacy are contingent on factors like purity, quality control, and accurate labeling. This paper contributes to the ongoing discourse on the integrity and security of nutraceutical products, urging a more informed and discerning approach to their consumption.

Abstract 320 | pdf Downloads 121

References

1. Dudeja P, Gupta RK. Nutraceuticals. In Food safety in the 21st century 2017 Jan 1 (pp. 491-496). Academic Press.
2. Gupta RC, Srivastava A, Lall R. Toxicity potential of nutraceuticals. Computational toxicology: methods and protocols. 2018:367-94.
3. Kalra EK. Nutraceutical-definition and introduction. Aaps Pharmsci. 2003 Sep;5(3):25.
4. Sachdeva V, Roy A, Bharadvaja N. Current prospects of nutraceuticals: A review. Current pharmaceutical biotechnology. 2020 Aug 1;21(10):884-96.
5. Bailey RL, Gahche JJ, Miller PE, Thomas PR, Dwyer JT. Why US adults use dietary supplements. JAMA internal medicine. 2013 Mar 11;173(5):355-61.
6. Moyer MW. Vitamins on trial. Nature. 2014 Jun 26;510(7506):462.
7. Weaver CM, Alekel DL, Ward WE, Ronis MJ. Flavonoid intake and bone health. Journal of nutrition in gerontology and geriatrics. 2012 Jul 1;31(3):239-53.
8. Oketch-Rabah HA, Roe AL, Rider CV, Bonkovsky HL, Giancaspro GI, Navarro V, Paine MF, Betz JM, Marles RJ, Casper S, Gurley B. United States Pharmacopeia (USP) comprehensive review of the hepatotoxicity of green tea extracts. Toxicology reports. 2020 Jan 1;7:386-402.
9. Mulholland CA, Benford DJ. What is known about the safety of multivitamin-multimineral supplements for the generally healthy population? Theoretical basis for harm. The American journal of clinical nutrition. 2007 Jan 1;85(1):318S-22S.
10. Guallar E, Stranges S, Mulrow C, Appel LJ, Miller III ER. Enough is enough: stop wasting money on vitamin and mineral supplements. Annals of internal medicine. 2013 Dec 17;159(12):850-1.
11. Fortmann SP, Burda BU, Senger CA, Lin JS, Whitlock EP. Vitamin and mineral supplements in the primary prevention of cardiovascular disease and cancer: an updated systematic evidence review for the US Preventive Services Task Force. Annals of internal medicine. 2013 Dec 17;159(12):824-34.
12. Bairati I, Meyer F, Gélinas M, Fortin A, Nabid A, Brochet F, Mercier JP, Têtu B, Harel F, Abdous B, Vigneault É. Randomized trial of antioxidant vitamins to prevent acute adverse effects of radiation therapy in head and neck cancer patients. Journal of clinical oncology. 2005 Aug 20;23(24):5805-13.
13. Miller III ER, Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Annals of internal medicine. 2005 Jan 4;142(1):37-46.
14. Rothman KJ, Moore LL, Singer MR, Nguyen US, Mannino S, Milunsky A. Teratogenicity of high vitamin A intake. New England Journal of Medicine. 1995 Nov 23;333(21):1369-73.
15. Ramanathan VS, Hensley G, French S, Eysselein V, Chung D, Reicher S, Pham B. Hypervitaminosis A inducing intra-hepatic cholestasis—a rare case report. Experimental and Molecular Pathology. 2010 Apr 1;88(2):324-5.
16. Barton JC, Lee PL, West C, Bottomley SS. Iron overload and prolonged ingestion of iron supplements: Clinical features and mutation analysis of hemochromatosis‐associated genes in four cases. American journal of hematology. 2006 Oct;81(10):760-7.
17. Swanson CA. Iron intake and regulation: implications for iron deficiency and iron overload. Alcohol. 2003 Jun 1;30(2):99-102.
18. Doron S, Snydman DR. Risk and safety of probiotics. Clinical Infectious Diseases. 2015 May 15;60(suppl_2):S129-34.
19. Besselink MG, van Santvoort HC, Buskens E, Boermeester MA, van Goor H, Timmerman HM, Nieuwenhuijs VB, Bollen TL, van Ramshorst B, Witteman BJ, Rosman C. Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial. The Lancet. 2008 Feb 23;371(9613):651-9.
20. Munakata S, Arakawa C, Kohira R, Fujita Y, Fuchigami T, Mugishima H. A case of D-lactic acid encephalopathy associated with use of probiotics. Brain and Development. 2010 Sep 1;32(8):691-4.
21. Vaarala O. Immunological effects of probiotics with special reference to lactobacilli. Clinical & Experimental Allergy. 2003 Dec;33(12):1634-40.
22. Lin CF, Fung ZF, Wu CL, Chung TC. Molecular Characterization of a Plasmid-Borne (pTC82) Chloramphenicol Resistance Determinant (cat-TC) fromLactobacillus reuteriG4. Plasmid. 1996 Sep 1;36(2):116-24.
23. Dessart SR, Steenson LR. High frequency intergeneric and intrageneric conjugal transfer of drug resistance plasmids in Leuconostoc mesenteroides ssp. cremoris. Journal of Dairy Science. 1991 Sep 1;74(9):2912-9.
24. Morelli L, Sarra PG, Bottazzi V. In vivo transfer of pAMβ1 from Lactobacillus reuteri to Enterococcus faecalis. Journal of Applied Bacteriology. 1988 Nov;65(5):371-5.
25. Fang N, Yu S, Badger TM. Comprehensive phytochemical profile of soy protein isolate. Journal of agricultural and food chemistry. 2004 Jun 16;52(12):4012-20.
26. Harlid S, Adgent M, Jefferson WN, Panduri V, Umbach DM, Xu Z, Stallings VA, Williams CJ, Rogan WJ, Taylor JA. Soy formula and epigenetic modifications: analysis of vaginal epithelial cells from infant girls in the IFED study. Environmental health perspectives. 2017 Mar;125(3):447-52.
27. Tan KA, Walker M, Morris K, Greig I, Mason JI, Sharpe RM. Infant feeding with soy formula milk: effects on puberty progression, reproductive function and testicular cell numbers in marmoset monkeys in adulthood. Human Reproduction. 2006 Apr 1;21(4):896-904.
28. McCarver G, Bhatia J, Chambers C, Clarke R, Etzel R, Foster W, Hoyer P, Leeder JS, Peters JM, Rissman E, Rybak M. NTP‐CERHR expert panel report on the developmental toxicity of soy infant formula. Birth Defects Research Part B: Developmental and Reproductive Toxicology. 2011 Oct;92(5):421-68.
29. Bailey RL, Gahche JJ, Lentino CV, Dwyer JT, Engel JS, Thomas PR, Betz JM, Sempos CT, Picciano MF. Dietary supplement use in the United States, 2003–2006. The Journal of nutrition. 2011 Feb 1;141(2):261-6.
30. Enbom ET, Le MD, Oesterich L, Rutgers J, French SW. Mechanism of hepatotoxicity due to black cohosh (Cimicifuga racemosa): histological, immunohistochemical and electron microscopy analysis of two liver biopsies with clinical correlation. Experimental and molecular pathology. 2014 Jun 1;96(3):279-83.
31. Lieberman HR, Stavinoha TB, McGraw SM, White A, Hadden LS, Marriott BP. Use of dietary supplements among active-duty US Army soldiers. The American journal of clinical nutrition. 2010 Oct 1;92(4):985-95.
32. Hoyte CO, Albert D, Heard KJ. The use of energy drinks, dietary supplements, and prescription medications by United States college students to enhance athletic performance. Journal of community health. 2013 Jun;38:575-80.
33. Navarro VJ, Khan I, Björnsson E, Seeff LB, Serrano J, Hoofnagle JH. Liver injury from herbal and dietary supplements. Hepatology. 2017 Jan;65(1):363-73.
34. 45. Raman P, Patino LC, Nair MG. Evaluation of metal and microbial contamination in botanical supplements. J Agric Food Chem. 2004 Dec 29;52(26):7822-7. doi: 10.1021/jf049150+. PMID: 15612762.
35. 46. Gan F, Hou L, Zhou Y, Liu Y, Huang D, Chen X, Huang K. Effects of ochratoxin A on ER stress, MAPK signaling pathway and autophagy of kidney and spleen in pigs. Environmental toxicology. 2017 Oct;32(10):2277-86.
36. 47. Prado G, Altoé AF, Gomes TC, Leal AS, Morais VA, Oliveira MS, Ferreira MB, Gomes MB, Paschoal FN, Souza RV, Silva DA. Occurrence of aflatoxin B1 in natural products. Brazilian Journal of Microbiology. 2012;43:1428-35.
37. 48. Sharif MK, Khalid R. Nutraceuticals: myths versus realities. InTherapeutic foods 2018 Jan 1 (pp. 3-21). Academic Press.
38. 49. Nikolić G, Marković D. MISCONCEPTIONS ABOUT NUTRITIONAL SUPPLEMENTS AND MODERN DISEASES. Hrana u zdravlju i bolesti [Internet]. 2015 [cited 2023 November 28];4(1):34-47.
39. 50. Isidoro C, Huang CC, Sheen LY. Report from the second international conference of traditional and complementary medicine on health 2015. Journal of traditional and complementary medicine. 2016 Jan 1;6(1):5-9.
40. Top of Form