FORMULATION DEVELOPMENT AND EVALUATION OF TOPICAL DRUG DELIVERY SYSTEM

Main Article Content

Dr. Shashikant D. Barhate
Dr. Sandip R. Pawar

Keywords

Rizatriptan, Migraine, Topical drug

Abstract

Topical delivery has been developed for variety of disease and disorders. The treatment of skin diseases additionally as musculoskeletal disorders may well be advantageous from topical administration obtaining a substantial reduction in oral side effects with improved patient compliance. Many anti-inflammatory drugs are poorly water soluble and Nano suspension is that the techniques which is employed to enhance this characteristic, so anti-inflammatory drugs are chosen as a model for this study. Rizatriptan is employed to treat migraines. It helps to alleviate headache, pain, and other migraine symptoms (including nausea, vomiting, and sensitivity to light/sound). Prompt treatment helps you come back to your normal routine and should decrease your need for other pain medications. Rizatriptan belongs to a category of medicine called triptans. It affects a specific natural substance (serotonin) that causes narrowing of blood vessels within the brain. It’s going to also relieve ache by affecting certain nerves inside the brain. Rizatriptan don't prevent future migraines or lessen how often you get migraine attacks the improved adoption of topical medication in current years has been impressive. this can be largely thanks to the very fact that the medication has proven to own more advantages than drawbacks. After all, the skin is right for drug administration, because it produces both systematic and native effects. Call it a life-changing medical innovation. Topical drug delivery systems have surely changed the way we glance at medication. More and more medical institutions and health practitioners are adopting this kind of medication in an endeavor to boost their services to patients.

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References

1. Bhowmik D, Harish GB, Kumar P, Duraivel S, Kumar SKP. Recent Advances In Novel Topical Drug Delivery System. The Pharma Innovation 2012;1(9): 12-30.
2. Verma A, Singh S, Kaur R, Jain UK. Topical Gels as Drug Delivery Systems. A Review: International Journal of Pharmaceutical Sciences Review And Research 2013;23(2):374-382.
3. Sonaje S, Gondkar SB, Saudagar RB. Gellified Emulsion A New Born Formulation for Topical Delivery of Hydrophobic Drug. World Journal of Pharmacy and Pharmaceutical Science 2013;1(3):233-251.
4. Basera K, Bhatt G, Kothiyal P, Gupta P. Nanoemulgel A Novel Formulation Approach for Topical Delivery of Hydrophobic Drugs. World Journal of Pharmacy and Pharmaceutical Science 2015;4(10):1872-1876.
5. Aulton M.E., Aulton’s Pharmaceutics, The Design and Manufacture of Medicine. 3rdEd., Churchil Livingstone 2007:390.
6. Herbert A. Liberman, Pharmaceutical Dosage Forms, Disperse Systems, Published By Marcel Dekkar, 2nd, 2005, Page No. 1, 57.
7. Katiyar BS, Katiyar SS, Mishra PS, Sailaja DL. Microemulsions: A Novel Drug Carrier System. International Journal of Pharmaceutical Sciences Review And Research 2013;20(2):139.
8. Haritha, Sayed PB, Koteswara RP, Chakravarthi V. A Brief Introduction To Methods of Preparation, Applications and Characterization of Nanoemulsion Drug Delivery Systems. Indian Journal of Research in Pharmacy and Biotechnology 2006;1(1):25-28.
9. Christofori M. R. R. Nastiti, Thellie Ponto, Emanabd, Topical Nano And Microemulsions For Skin Delivery, Pharmaceutics, 2017, Volume 9, Issue 37, Page No. 3.
10. Form and Drug Delivery System, 7th ed, New York Lippincoott Williams and Wilkins. 1999: 394- 400,278-280,405-407.
11. Setya S, legaonkar S, Razdan BK. Nanoemulsion: Formulation Method and Stability aspect. World Journal of Pharmacy and Pharmaceutical Sciences 2014;3(2):2218, 2214, 2222.
12. Thakur N, Garg G, Sharma PK, Kumar N. Nanoemulsion A Review on Various Pharmaceutical Application. Global Journal of Pharmacology 2012;6(3):222-225