DEVELOPMENT AND EVALUATION OF HERBAL CREAM FOR RHEUMATISM
Main Article Content
Keywords
Morinda Tinctoria, ridax Procumbens, Herbal Cosmetics,, Anti-Inflammatory Cream
Abstract
Aim: The present study was to formulate and evaluate the herbal cream comprising extracts of different medicinal plants.
Experimental: Using a Soxhlet apparatus, an aqueous extract of all the chosen plants (Morinda Tinctoria, Tridax Procumbens) was created through a series of solvent extraction steps. A topical herbal cream was created and tested for several qualities, including stability, spreadability, pH, consistency, color, and viscosity. Using incision and excision wound models, a pharmacological assessment of a herbal cream formulation was conducted.
Result and Conclusion:It can be inferred from the results of the various evaluation parameters that the prepared herbal formulation was secure and safe to use in the process of wound healing.
References
1. Schmiedel Y, Zimmerli S. Common invasive fungal diseases: An overview of invasive candidiasis, aspergillosis, cryptococcosis, and Pneumocystis pneumonia. Swiss Medical Weekly, 2016.
2. Fisher M, Hawkins N, Sanglard D, Gurr S. Worldwide emergence of resistance to antifungal drugs challenges human health and food security. Science. 2018;360(6390):739-742.
3. Urban K, Chu S, Scheufele C, Giesey R, Mehrmal S, Uppal P, et al. The global, regional, and national burden of fungal skin diseases in 195 countries and territories: A ~ 295 ~ Journal of Pharmacognosy and Phytochemistry, cross-sectional analysis from the Global Burden of Disease Study 2017. JAAD International. 2021; 2:22-27.
4. Vallabhaneni S, Mody R, Walker T, Chiller T. The Global Burden of Fungal Diseases. Infectious Disease Clinics of North America. 2016;30(1):1-11.
5. Beck S, Mathison H, Todorov T, Calderon-Juarez E, Kopp O. A Review of Medicinal Uses and Pharmacological Activities of Tridax procumbens (L.). Journal of Plant Studies. 2018;7(1):19.
6. Policegoudra R, Chattopadhyay P, Aradhya S, Shivaswamy R, Singh L, Veer V. Inhibitory effect of Tridax procumbens against human skin pathogens. Journal of Herbal Medicine. 2014;4(2):83-88.
7. Jhample S, Gajdhane S, Kasabe P, Bhagwat P, Dangde P. Phytochemical screening and in vitro antimicrobial activity of Tridax procumbens L. Research Journal of Life Sciences, Bioinformatics, Pharmaceutical and Chemical Sciences. 2015;1(1): 44.
8. Berlin Grace V, Viswanathan S, David Wilson D, Jagadish Kumar S, Sahana K, Maria Arbin E, et al. Significant action of Tridax procumbens L. leaf extract on reducing the TNF-α and COX-2 gene expressions in induced inflammation site in Swiss albino mice. Inflammopharmacology. 2019;28(4):929-938.
9. Akhtar N, Verma A, Pathak K. Topical Delivery of Drugs for the Effective Treatment of Fungal Infections of Skin. Current Pharmaceutical Design. 2015;21(20):2892- 2913.
10. Pimpale A. Formulation and Evaluation of Antibacterial, Antifungal Cream of Garlic Oil. International Journal of Trend in Scientific Research and Development. 2018;3(1):849-852.
11. Gemeda N, Tadele A, Lemma H, Girma B, Addis G, Tesfaye B, et al. Development, Characterization, and Evaluation of Novel Broad-Spectrum Antimicrobial Topical Formulations from Cymbopogon martini (Roxb) W. Watson Essential Oil. Evidence-Based Complementary and Alternative Medicine, 2018, 1-16.
12. Joshi R, Badakar V. Chemical Composition and in vitro Antimicrobial Activity of the Essential Oil of the Flowers of Tridax procumbens. Natural Product Communications. 2012; 7(7): 1934578X1200700.
13. Sarkar S, Saha P, Sultana N. In vitro evaluation of phytochemical components and antimicrobial activity of the methanolic extract of Tridax procumbens L. against pathogenic microorganisms. Journal of Pharmacognosy and Phytochemistry. 2016;5(5):42-46.
14. Sujitha, R, Sharmila R. Phytochemical Analysis and In vitro Anticancer Activity of Tridax procumbens Linn. World Journal of Pharmaceutical Research. 2018;7(10):867-878
15. Sumeet Dwivedi, Shailesh Gupta, Formulation and Evaluation of Herbal Gel Containing Sesbania grandifolora Poir. Leaf Extract, Acta Chimica and Pharmaceutical India,2012, pp.54-59.
A. Gupta, Formulation and Evaluation of Topical Gel of Diclofenac Sodium Using Different Polymers, Drug Invention Today,2010, 2(5), pp. 250-253.
16. Yogesh P Talekar, Biswadeep Das, Tania Paul, Evaluation of Wound Healing Potential of Aqueous and Ethanolic Extract of Tridax procumbens Linn. In Wistar Rats 20.K.R.Khandelwal, Vrunda Sethi, Practical Pharmacognosy, Nirali prakashan, 2013, pp. 25.1- 25.7
17. Rajesh B., Saumya Das, Pattanayak Dharmajit, M. Pavani, Formulation Design And Optimization Of Herbal Gel Containing Albizia lebbeck Bark Extract, International Journal Of Pharmacy And Pharmaceutical Sciences, Vol.6, 2014, pp.111-114.
18. Shivprasad Majumdar, Ruchi Dave, Formulation Study of Gel Containing Pterocarpus santalinus Extract For Its Anti-inflammatory Activity, World Journal Of Pharmacy And Pharmaceutical Science, Vol.2 2013, pp.4951-4964.
19. Megha Patel, Nikunjana A. Patel, Formulation and Evaluation Of Polyherbal Gel For Wound Healing, International Research Journal Of Research Journal Of Pharmaceuticals, Vol.01,2011, pp.15-20
20. Mali AS, Karekar P, Yadav AV. Formulation and evaluation of multipurpose herbal cream. Int J Sci Res. 2015; 4(11): 1495-1497.
21. Christaki EV, Florou-Paneri PC. Aloe vera: A plant for many uses. J Food Agric Environ. 2010; 8(2): 245-249.
22. Bhowmik D, Chiranjib YJ, Tripathi KK, Kumar KS. Herbal remedies of Azadirachta indica and its medicinal application. J Chem Pharm Res. 2010; 2(1): 62-72.
23. Sah AK, Vijaysimha M, Mahamood M. The tulsi, queen of green medicines: Biochemistry and pathophysiology-a review. Int J Pharm Sci Rev Res. 2018; 50(2): 106-114.
24. Viswanathan MV, Unnikrishnan PM, Komatsu K, Fushimi H, Basnet P. A brief introduction to Ayurvedic system of medicine and some of its problems. Indian J Tradit Knowl. 2003; 2(2): 159-169.
25. Imhof A, Pine DJ. Stability of nonaqueous emulsions. J Colloid Interface Sci. 1997; 192(2): 368-374.
26. Bleckmann A, Kropke R, Schneider G, Beiersdorf AG. Preparation of the w/o emulsion type with an increased water content, additionally comprising one or more alkylmethicone copolyols and/ or alkyldimethicone copolyols, and cationic polymers. US patent application. 2021.
27. Kapoor S, Saraf S. Formulation and evaluation of moisturizer containing herbal extracts for the management of dry skin. Pharmacog J. 2010; 2(11): 409-417.
28. Ashara K, Soniwala MM, Paun J, Chawda J. Importance of trituration technique on preparation and evaluation of cold cream. Inventi Rapid Pharm Tech. 2013: 1-2.
29. Gupta N, Dubey A, Prasad P, Roy A. Formulation and evaluation of herbal fairness cream comprising hydroalcoholic extracts of Pleurotus ostreatus, Glycyrrhiza glabra and Camellia sinensis. Pharma Bio Sci J. 2015: 40-45.
30. Rignall A. ICHQ1A (R2) stability testing of new drug substance and product and ICHQ1C stability testing of new dosage forms. ICH quality guidelines: An implementation guide. 2017.
31. Meenakshi S, Raghavan G, Virendra N, Kumar A, Shantha M. Antimicrobial, wound healing and antioxidant activity of Plagiochasma appendiculatum Lehm. Journal of Ethnopharmacology. 2006; 107:67–72.
32. Priya KS, Gnanamani A, Radhakrishnan N, Babu M. Healing potential of Datura alba on burn wounds in albino rats. Journal of Ethnopharmacology. 2002; 83:193-199.
33. Fabio Carmona, Ana Maria, Soares Pereira. Herbal medicines: old and new concepts, truths and misunderstandings. Brazilian Journal of Pharmacognosy. 2013; 23(2):379-385.
34. Koehn FE, Carter GT. The evolving role of natural products in drug discovery. Nature Review Drug Discovery. 2005; 4 (3):206-22
2. Fisher M, Hawkins N, Sanglard D, Gurr S. Worldwide emergence of resistance to antifungal drugs challenges human health and food security. Science. 2018;360(6390):739-742.
3. Urban K, Chu S, Scheufele C, Giesey R, Mehrmal S, Uppal P, et al. The global, regional, and national burden of fungal skin diseases in 195 countries and territories: A ~ 295 ~ Journal of Pharmacognosy and Phytochemistry, cross-sectional analysis from the Global Burden of Disease Study 2017. JAAD International. 2021; 2:22-27.
4. Vallabhaneni S, Mody R, Walker T, Chiller T. The Global Burden of Fungal Diseases. Infectious Disease Clinics of North America. 2016;30(1):1-11.
5. Beck S, Mathison H, Todorov T, Calderon-Juarez E, Kopp O. A Review of Medicinal Uses and Pharmacological Activities of Tridax procumbens (L.). Journal of Plant Studies. 2018;7(1):19.
6. Policegoudra R, Chattopadhyay P, Aradhya S, Shivaswamy R, Singh L, Veer V. Inhibitory effect of Tridax procumbens against human skin pathogens. Journal of Herbal Medicine. 2014;4(2):83-88.
7. Jhample S, Gajdhane S, Kasabe P, Bhagwat P, Dangde P. Phytochemical screening and in vitro antimicrobial activity of Tridax procumbens L. Research Journal of Life Sciences, Bioinformatics, Pharmaceutical and Chemical Sciences. 2015;1(1): 44.
8. Berlin Grace V, Viswanathan S, David Wilson D, Jagadish Kumar S, Sahana K, Maria Arbin E, et al. Significant action of Tridax procumbens L. leaf extract on reducing the TNF-α and COX-2 gene expressions in induced inflammation site in Swiss albino mice. Inflammopharmacology. 2019;28(4):929-938.
9. Akhtar N, Verma A, Pathak K. Topical Delivery of Drugs for the Effective Treatment of Fungal Infections of Skin. Current Pharmaceutical Design. 2015;21(20):2892- 2913.
10. Pimpale A. Formulation and Evaluation of Antibacterial, Antifungal Cream of Garlic Oil. International Journal of Trend in Scientific Research and Development. 2018;3(1):849-852.
11. Gemeda N, Tadele A, Lemma H, Girma B, Addis G, Tesfaye B, et al. Development, Characterization, and Evaluation of Novel Broad-Spectrum Antimicrobial Topical Formulations from Cymbopogon martini (Roxb) W. Watson Essential Oil. Evidence-Based Complementary and Alternative Medicine, 2018, 1-16.
12. Joshi R, Badakar V. Chemical Composition and in vitro Antimicrobial Activity of the Essential Oil of the Flowers of Tridax procumbens. Natural Product Communications. 2012; 7(7): 1934578X1200700.
13. Sarkar S, Saha P, Sultana N. In vitro evaluation of phytochemical components and antimicrobial activity of the methanolic extract of Tridax procumbens L. against pathogenic microorganisms. Journal of Pharmacognosy and Phytochemistry. 2016;5(5):42-46.
14. Sujitha, R, Sharmila R. Phytochemical Analysis and In vitro Anticancer Activity of Tridax procumbens Linn. World Journal of Pharmaceutical Research. 2018;7(10):867-878
15. Sumeet Dwivedi, Shailesh Gupta, Formulation and Evaluation of Herbal Gel Containing Sesbania grandifolora Poir. Leaf Extract, Acta Chimica and Pharmaceutical India,2012, pp.54-59.
A. Gupta, Formulation and Evaluation of Topical Gel of Diclofenac Sodium Using Different Polymers, Drug Invention Today,2010, 2(5), pp. 250-253.
16. Yogesh P Talekar, Biswadeep Das, Tania Paul, Evaluation of Wound Healing Potential of Aqueous and Ethanolic Extract of Tridax procumbens Linn. In Wistar Rats 20.K.R.Khandelwal, Vrunda Sethi, Practical Pharmacognosy, Nirali prakashan, 2013, pp. 25.1- 25.7
17. Rajesh B., Saumya Das, Pattanayak Dharmajit, M. Pavani, Formulation Design And Optimization Of Herbal Gel Containing Albizia lebbeck Bark Extract, International Journal Of Pharmacy And Pharmaceutical Sciences, Vol.6, 2014, pp.111-114.
18. Shivprasad Majumdar, Ruchi Dave, Formulation Study of Gel Containing Pterocarpus santalinus Extract For Its Anti-inflammatory Activity, World Journal Of Pharmacy And Pharmaceutical Science, Vol.2 2013, pp.4951-4964.
19. Megha Patel, Nikunjana A. Patel, Formulation and Evaluation Of Polyherbal Gel For Wound Healing, International Research Journal Of Research Journal Of Pharmaceuticals, Vol.01,2011, pp.15-20
20. Mali AS, Karekar P, Yadav AV. Formulation and evaluation of multipurpose herbal cream. Int J Sci Res. 2015; 4(11): 1495-1497.
21. Christaki EV, Florou-Paneri PC. Aloe vera: A plant for many uses. J Food Agric Environ. 2010; 8(2): 245-249.
22. Bhowmik D, Chiranjib YJ, Tripathi KK, Kumar KS. Herbal remedies of Azadirachta indica and its medicinal application. J Chem Pharm Res. 2010; 2(1): 62-72.
23. Sah AK, Vijaysimha M, Mahamood M. The tulsi, queen of green medicines: Biochemistry and pathophysiology-a review. Int J Pharm Sci Rev Res. 2018; 50(2): 106-114.
24. Viswanathan MV, Unnikrishnan PM, Komatsu K, Fushimi H, Basnet P. A brief introduction to Ayurvedic system of medicine and some of its problems. Indian J Tradit Knowl. 2003; 2(2): 159-169.
25. Imhof A, Pine DJ. Stability of nonaqueous emulsions. J Colloid Interface Sci. 1997; 192(2): 368-374.
26. Bleckmann A, Kropke R, Schneider G, Beiersdorf AG. Preparation of the w/o emulsion type with an increased water content, additionally comprising one or more alkylmethicone copolyols and/ or alkyldimethicone copolyols, and cationic polymers. US patent application. 2021.
27. Kapoor S, Saraf S. Formulation and evaluation of moisturizer containing herbal extracts for the management of dry skin. Pharmacog J. 2010; 2(11): 409-417.
28. Ashara K, Soniwala MM, Paun J, Chawda J. Importance of trituration technique on preparation and evaluation of cold cream. Inventi Rapid Pharm Tech. 2013: 1-2.
29. Gupta N, Dubey A, Prasad P, Roy A. Formulation and evaluation of herbal fairness cream comprising hydroalcoholic extracts of Pleurotus ostreatus, Glycyrrhiza glabra and Camellia sinensis. Pharma Bio Sci J. 2015: 40-45.
30. Rignall A. ICHQ1A (R2) stability testing of new drug substance and product and ICHQ1C stability testing of new dosage forms. ICH quality guidelines: An implementation guide. 2017.
31. Meenakshi S, Raghavan G, Virendra N, Kumar A, Shantha M. Antimicrobial, wound healing and antioxidant activity of Plagiochasma appendiculatum Lehm. Journal of Ethnopharmacology. 2006; 107:67–72.
32. Priya KS, Gnanamani A, Radhakrishnan N, Babu M. Healing potential of Datura alba on burn wounds in albino rats. Journal of Ethnopharmacology. 2002; 83:193-199.
33. Fabio Carmona, Ana Maria, Soares Pereira. Herbal medicines: old and new concepts, truths and misunderstandings. Brazilian Journal of Pharmacognosy. 2013; 23(2):379-385.
34. Koehn FE, Carter GT. The evolving role of natural products in drug discovery. Nature Review Drug Discovery. 2005; 4 (3):206-22
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Published
Dec 28, 2023
Article Details
How to Cite
Ranganathan K, Jeevanandham S, Nandhini.A, Preethi.M, Rinshida P.A, Sakthivel.M, & Mohammed Basith.M. (2023). DEVELOPMENT AND EVALUATION OF HERBAL CREAM FOR RHEUMATISM. Journal of Population Therapeutics and Clinical Pharmacology, 30(19), 1452-1463. https://doi.org/10.53555/jptcp.v30i19.3850
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Author Biographies
Ranganathan K
Department of Pharmaceutics, Sree Abirami college of Pharmacy, Eachanari, Coimbatore – 641 021, India
Jeevanandham S
Department of Pharmaceutics, Sree Abirami college of Pharmacy, Eachanari, Coimbatore – 641 021, India
Nandhini.A
Department of Pharmaceutics, Sree Abirami college of Pharmacy, Eachanari, Coimbatore – 641 021, India
Preethi.M
Department of Pharmaceutics, Sree Abirami college of Pharmacy, Eachanari, Coimbatore – 641 021, India
Rinshida P.A
Department of Pharmaceutics, Sree Abirami college of Pharmacy, Eachanari, Coimbatore – 641 021, India
Sakthivel.M
Department of Pharmaceutics, Sree Abirami college of Pharmacy, Eachanari, Coimbatore – 641 021, India
Mohammed Basith.M
Department of Pharmaceutics, Sree Abirami college of Pharmacy, Eachanari, Coimbatore – 641 021, India
How to Cite
Ranganathan K, Jeevanandham S, Nandhini.A, Preethi.M, Rinshida P.A, Sakthivel.M, & Mohammed Basith.M. (2023). DEVELOPMENT AND EVALUATION OF HERBAL CREAM FOR RHEUMATISM. Journal of Population Therapeutics and Clinical Pharmacology, 30(19), 1452-1463. https://doi.org/10.53555/jptcp.v30i19.3850