NUTRITIONAL STRATEGIES FOR ALLEVIATING SYMPTOMS OF POLYCYSTIC OVARIAN SYNDROME: A REVIEW OF CLINICAL EVIDENCE
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Keywords
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Abstract
This article offers a comprehensive synthesis of PubMed findings on Polycystic Ovary Syndrome (PCOS), delving into its intricate impact on lipid, carbohydrate, and hormonal metabolism. Exploring causative factors, disease progression, and dietary interventions, it also addresses associated health issues such as sleep disorders, mental health alterations, oxidative stress, and inflammation. PCOS is linked to severe complications like diabetes, organ fatty degeneration, infertility, cardiovascular diseases, dysbiosis, and cancer. The article underscores the modifiable nature of PCOS progression, emphasizing lifestyle adjustments, dietary choices, and nutrient selection. It explores both pharmaceutical and natural interventions, particularly herbal supplements, nutraceuticals strategies. The significance of individualized care is emphasized, acknowledging the interplay between lifestyle, genetics, and PCOS impact. In conclusion, this analysis contributes valuable insights into the complex interconnections of PCOS, metabolic pathways, and associated health outcomes, offering strategies for managing and alleviating this prevalent endocrine disorder through targeted dietary interventions and nutrient interventions with supplementation and functional food.
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23. Scarfò, G. et al. (2022) ‘Metabolic and Molecular Mechanisms of Diet and Physical Exercise in the Management of Polycystic Ovarian Syndrome’, Biomedicines, 10(6), pp. 1–22. Available at: https://doi.org/10.3390/biomedicines10061305.
24. Szczuko, M. et al. (2017) ‘Significant improvement selected mediators of inflammation in phenotypes of women with PCOS after reduction and low GI diet’, Mediators of Inflammation, 2017. Available at: https://doi.org/10.1155/2017/5489523.
25. Szczuko, M. et al. (2021) ‘Nutrition strategy and life style in polycystic ovary syndrome—narrative review’, Nutrients, 13(7), pp. 1–18. Available at: https://doi.org/10.3390/nu13072452.
26. Szczuko, M., Szydłowska, I. and Nawrocka-Rutkowska, J. (2021) ‘A properly balanced reduction diet and/or supplementation solve the problem with the deficiency of these vitamins soluble in water in patients with pcos’, Nutrients, 13(3), pp. 1–10. Available at: https://doi.org/10.3390/nu13030746.
27. Tobergte, D.R. and Curtis, S. (2013) ‘Nutrition, Metabolism and Cardiovascular Diseases’, Normasn revista, pp. 1689–1699.
28. Unfer, V. (2021) ‘A deeper assessment of ω3-poly-unsaturated fatty acids in polycystic ovary syndrome management. Comment on regidor et al. chronic inflammation in PCOS: The potential benefits of specialized pro-resolving lipid mediators (SPMs) in the improvement of the re’, International Journal of Molecular Sciences, 22(18), pp. 14–16. Available at: https://doi.org/10.3390/ijms221810114.
29. Yang, M. et al. (2022) ‘Effects of a ketogenic diet in women with PCOS with different uric acid concentrations: a prospective cohort study’, Reproductive BioMedicine Online, 45(2), pp. 391–400. Available at: https://doi.org/10.1016/j.rbmo.2022.03.023.
30. Yuandani et al. (2021) ‘Immunomodulatory Effects and Mechanisms of Curcuma Species and Their Bioactive Compounds: A Review’, Frontiers in Pharmacology, 12(April), pp. 1–26. Available at: https://doi.org/10.3389/fphar.2021.643119.
31. Zhou, Y. et al. (2019) ‘Total flavonoids extracted from Nervilia Fordii function in polycystic ovary syndrome through IL-6 mediated JAK2/STAT3 signaling pathway’, Bioscience Reports, 39(1), pp. 1–11. Available at: https://doi.org/10.1042/BSR20181380.
2. Che, X. et al. (2021) ‘Dietary Interventions: A Promising Treatment for Polycystic Ovary Syndrome’, Annals of Nutrition and Metabolism, 77(6), pp. 313–323. Available at: https://doi.org/10.1159/000519302.
3. Cincione, R.I. et al. (2021) ‘Effects of mixed of a ketogenic diet in overweight and obese women with polycystic ovary syndrome’, International Journal of Environmental Research and Public Health, 18(23). Available at: https://doi.org/10.3390/ijerph182312490.
4. Di Emidio, G. et al. (2020) ‘Regulatory functions of l-carnitine, acetyl, and propionyl l-carnitine in a PCOS mouse model: Focus on antioxidant/antiglycative molecular pathways in the ovarian microenvironment’, Antioxidants, 9(9), pp. 1–17. Available at: https://doi.org/10.3390/antiox9090867.
5. Fauser, B.C.J.M. et al. (2012) ‘Consensus on women’s health aspects of polycystic ovary syndrome (PCOS): The Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group’, Fertility and Sterility, 97(1), pp. 28-38.e25. Available at: https://doi.org/10.1016/j.fertnstert.2011.09.024.
6. Ferro, D. et al. (2020) ‘New insights into the pathogenesis of non-alcoholic and oxidative stress’, Nutrients, 12, p. 2762.
7. He, C. et al. (2015) ‘Serum vitamin d levels and polycystic ovary syndrome: A systematic review and meta-analysis’, Nutrients, 7(6), pp. 4555–4577. Available at: https://doi.org/10.3390/nu7064555.
8. Hong, G. et al. (2020) ‘Catechins from oolong tea improve uterine defects by inhibiting STAT3 signaling in polycystic ovary syndrome mice’, Chinese Medicine (United Kingdom), 15(1), pp. 1–17. Available at: https://doi.org/10.1186/s13020-020-00405-y.
9. Kakadia, N. et al. (2019) ‘Effect of Vitex negundo L. seeds in letrozole induced polycystic ovarian syndrome’, Journal of Traditional and Complementary Medicine, 9(4), pp. 336–345. Available at: https://doi.org/10.1016/j.jtcme.2018.03.001.
10. Kazemi, M. et al. (2021) ‘Effects of Dietary Glycemic Index and Glycemic Load on Cardiometabolic and Reproductive Profiles in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis of Randomized Controlled Trials’, Advances in Nutrition, 12(1), pp. 161–178. Available at: https://doi.org/10.1093/advances/nmaa092.
11. Lucidi, R.S. et al. (2005) ‘Effect of chromium supplementation on insulin resistance and ovarian and menstrual cyclicity in women with polycystic ovary syndrome’, Fertility and Sterility, 84(6), pp. 1755–1757. Available at: https://doi.org/10.1016/j.fertnstert.2005.06.028.
12. MacDonald-Ramos, K. et al. (2021) ‘Silymarin is an ally against insulin resistance: A review’, Annals of Hepatology, 23, p. 100255. Available at: https://doi.org/10.1016/j.aohep.2020.08.072.
13. Mas-Bargues, C. et al. (2021) ‘Lipid peroxidation as measured by chromatographic determination of malondialdehyde. Human plasma reference values in health and disease’, Archives of Biochemistry and Biophysics, 709. Available at: https://doi.org/10.1016/j.abb.2021.108941.
14. Mavropoulos, J.C. et al. (2005) ‘The effects of a low-carbohydrate, ketogenic diet on the polycystic ovary syndrome: A pilot study’, Nutrition and Metabolism, 2, pp. 1–5. Available at: https://doi.org/10.1186/1743-7075-2-35.
15. Maxel, T. et al. (2017) ‘Expression patterns and correlations with metabolic markers of zinc transporters ZIP14 and ZNT1 in obesity and polycystic ovary syndrome’, Frontiers in Endocrinology, 8(MAR), pp. 1–11. Available at: https://doi.org/10.3389/fendo.2017.00038.
16. Moran, L.J. et al. (2009) ‘Treatment of obesity in polycystic ovary syndrome: a position statement of the Androgen Excess and Polycystic Ovary Syndrome Society’, Fertility and Sterility, 92(6), pp. 1966–1982. Available at: https://doi.org/10.1016/j.fertnstert.2008.09.018.
17. Nafld, D. et al. (no date) ‘nutrients’, pp. 1–13.
18. Nasiadek, M., Stragierowicz, J. and Kilanowicz, A. (2020) ‘System Disorders’, pp. 2–3.
19. Papavasiliou, K. and Papakonstantinou, E. (2017) ‘Nutritional support and dietary interventions for women with polycystic ovary syndrome’, Nutrition and Dietary Supplements, Volume 9, pp. 63–85. Available at: https://doi.org/10.2147/nds.s119738.
20. Rudnicka, E. et al. (2021) ‘Chronic low grade inflammation in pathogenesis of pcos’, International Journal of Molecular Sciences, 22(7), pp. 1–12. Available at: https://doi.org/10.3390/ijms22073789.
21. Salek, M. et al. (2019) ‘N-3 fatty acids as preventive and therapeutic agents in attenuating pcos complications’, EXCLI Journal, 18, pp. 558–575. Available at: https://doi.org/10.17179/excli2019-1534.
22. Sarma Kataki, M. (2012) ‘Antioxidant, Hepatoprotective, and Anthelmintic Activities of Methanol Extract of Urtica dioica L. Leaves’, Pharmaceutical Crops, 3(1), pp. 38–46. Available at: https://doi.org/10.2174/2210290601203010038.
23. Scarfò, G. et al. (2022) ‘Metabolic and Molecular Mechanisms of Diet and Physical Exercise in the Management of Polycystic Ovarian Syndrome’, Biomedicines, 10(6), pp. 1–22. Available at: https://doi.org/10.3390/biomedicines10061305.
24. Szczuko, M. et al. (2017) ‘Significant improvement selected mediators of inflammation in phenotypes of women with PCOS after reduction and low GI diet’, Mediators of Inflammation, 2017. Available at: https://doi.org/10.1155/2017/5489523.
25. Szczuko, M. et al. (2021) ‘Nutrition strategy and life style in polycystic ovary syndrome—narrative review’, Nutrients, 13(7), pp. 1–18. Available at: https://doi.org/10.3390/nu13072452.
26. Szczuko, M., Szydłowska, I. and Nawrocka-Rutkowska, J. (2021) ‘A properly balanced reduction diet and/or supplementation solve the problem with the deficiency of these vitamins soluble in water in patients with pcos’, Nutrients, 13(3), pp. 1–10. Available at: https://doi.org/10.3390/nu13030746.
27. Tobergte, D.R. and Curtis, S. (2013) ‘Nutrition, Metabolism and Cardiovascular Diseases’, Normasn revista, pp. 1689–1699.
28. Unfer, V. (2021) ‘A deeper assessment of ω3-poly-unsaturated fatty acids in polycystic ovary syndrome management. Comment on regidor et al. chronic inflammation in PCOS: The potential benefits of specialized pro-resolving lipid mediators (SPMs) in the improvement of the re’, International Journal of Molecular Sciences, 22(18), pp. 14–16. Available at: https://doi.org/10.3390/ijms221810114.
29. Yang, M. et al. (2022) ‘Effects of a ketogenic diet in women with PCOS with different uric acid concentrations: a prospective cohort study’, Reproductive BioMedicine Online, 45(2), pp. 391–400. Available at: https://doi.org/10.1016/j.rbmo.2022.03.023.
30. Yuandani et al. (2021) ‘Immunomodulatory Effects and Mechanisms of Curcuma Species and Their Bioactive Compounds: A Review’, Frontiers in Pharmacology, 12(April), pp. 1–26. Available at: https://doi.org/10.3389/fphar.2021.643119.
31. Zhou, Y. et al. (2019) ‘Total flavonoids extracted from Nervilia Fordii function in polycystic ovary syndrome through IL-6 mediated JAK2/STAT3 signaling pathway’, Bioscience Reports, 39(1), pp. 1–11. Available at: https://doi.org/10.1042/BSR20181380.
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Dec 22, 2023
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Harmanjeet Kaur, & Dr. Santosh Kumar Verma. (2023). NUTRITIONAL STRATEGIES FOR ALLEVIATING SYMPTOMS OF POLYCYSTIC OVARIAN SYNDROME: A REVIEW OF CLINICAL EVIDENCE. Journal of Population Therapeutics and Clinical Pharmacology, 30(19), 959-967. https://doi.org/10.53555/jptcp.v30i19.3788
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Author Biographies
Harmanjeet Kaur
Quantum School of Health Sciences, Quantum University, Roorkee, India,
Dr. Santosh Kumar Verma
Quantum School of Health Sciences, Quantum University, Roorkee, India,
How to Cite
Harmanjeet Kaur, & Dr. Santosh Kumar Verma. (2023). NUTRITIONAL STRATEGIES FOR ALLEVIATING SYMPTOMS OF POLYCYSTIC OVARIAN SYNDROME: A REVIEW OF CLINICAL EVIDENCE. Journal of Population Therapeutics and Clinical Pharmacology, 30(19), 959-967. https://doi.org/10.53555/jptcp.v30i19.3788