Determining the effects of Vitamin D and Vitamin E administration in Psychiatric improvement of patients with mental health problems
Main Article Content
Keywords
Mental illness, Antipsychotic drugs, Vitamins
Abstract
Mental diseases, with their diverse effects on individuals, families, and society, are a major issue in today's world. The study of the benefits of giving Vitamin D and Vitamin E on psychiatric improvement in people with mental health disorders emphasizes the need for more research in this area.
Methodology
The study included 140 people with mental illnesses as well as vitamin D and vitamin E deficits. Based on 25-hydroxyvitamin D (25(OH) vitamin D) values of 10 ng/mL, baseline vitamin D levels were classified as deficiency, insufficiency, or sufficient. The participants had been taking antipsychotic drugs on a consistent basis for at least two months prior to the commencement of the trial.
Results The findings had revealed that a significant difference in the mean p<0.05 were observed among the patients in the experimental group where antipsychotic treatment alone had shown significant reduction in the BPRS and the combination of antipsychotic plus vitamin D and E.
Conclusion
In Conclusion, the data imply that combining vitamin D and E with antipsychotic medication may improve psychiatric outcomes in people with mental health issues
References
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15. Kaviani M, Nikooyeh B, Zand H, Yaghmaei P, Neyestani TR. Effects of vitamin D supplementation on depression and some involved neurotransmitters. Journal of affective disorders. 2020 May 15;269:28-35.
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18. Zhand N, Labelle A, Ghanem D, Gujral P, Han T, Huneault G, Jain GK, Robertson C. Comparison of Extrapyramidal Symptoms Among Outpatients With Schizophrenia on Long-Acting Injectable Antipsychotics. Journal of Clinical Psychopharmacology. 2022 Sep 1;42(5):475-9.
19. Jamilian H, Amirani E, Milajerdi A, Kolahdooz F, Mirzaei H, Zaroudi M, Ghaderi A, Asemi Z. The effects of vitamin D supplementation on mental health, and biomarkers of inflammation and oxidative stress in patients with psychiatric disorders: a systematic review and meta-analysis of randomized controlled trials. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2019 Aug 30;94:109651.
20. Al-Fartusie FS, Al-Bairmani HK, Al-Garawi ZS, Yousif AH. Evaluation of some trace elements and vitamins in major depressive disorder patients: a case–control study. Biological trace element research. 2019 Jun 15;189:412-9.
2. Blackmore R, Boyle JA, Fazel M, Ranasinha S, Gray KM, Fitzgerald G, Misso M, Gibson-Helm M. The prevalence of mental illness in refugees and asylum seekers: A systematic review and meta-analysis. PLoS medicine. 2020 Sep 21;17(9):e1003337.
3. Abel KM, Hope H, Swift E, Parisi R, Ashcroft DM, Kosidou K, Osam CS, Dalman C, Pierce M. Prevalence of maternal mental illness among children and adolescents in the UK between 2005 and 2017: a national retrospective cohort analysis. The Lancet Public Health. 2019 Jun 1;4(6):e291-300.
4. Afzal M, Siddiqi N, Ahmad B, Afsheen N, Aslam F, Ali A, Ayesha R, Bryant M, Holt R, Khalid H, Ishaq K. Prevalence of overweight and obesity in people with severe mental illness: systematic review and meta-analysis. Frontiers in Endocrinology. 2021 Nov 25;12:769309.
5. Laws MB, Beeman A, Haigh S, Wilson IB, Shield RR. Prevalence of serious mental illness and under 65 population in nursing homes continues to grow. Journal of the American Medical Directors Association. 2022 Jul 1;23(7):1262-3.
6. Nair S, Satyanarayana VA, Desai G. Prevalence and clinical correlates of intimate partner violence (IPV) in women with severe mental illness (SMI). Asian journal of psychiatry. 2020 Aug 1;52:102131.
7. Cuomo A, Maina G, Bolognesi S, Rosso G, Beccarini Crescenzi B, Zanobini F, Goracci A, Facchi E, Favaretto E, Baldini I, Santucci A. Prevalence and correlates of vitamin D deficiency in a sample of 290 inpatients with mental illness. Frontiers in psychiatry. 2019 Mar 29;10:167.
8. Moslemi E, Musazadeh V, Kavyani Z, Naghsh N, Shoura SM, Dehghan P. Efficacy of vitamin D supplementation as an adjunct therapy for improving inflammatory and oxidative stress biomarkers: An umbrella meta-analysis. Pharmacological Research. 2022 Oct 4:106484..
9. Kris-Etherton PM, Petersen KS, Hibbeln JR, Hurley D, Kolick V, Peoples S, Rodriguez N, Woodward-Lopez G. Nutrition and behavioral health disorders: depression and anxiety. Nutrition reviews. 2021 Mar;79(3):247-60.
10. Seyedi M, Gholami F, Samadi M, Djalali M, Effatpanah M, Yekaninejad MS, Hashemi R, Abdolahi M, Chamari M, Honarvar NM. The effect of vitamin D3 supplementation on serum BDNF, dopamine, and serotonin in children with attention-deficit/hyperactivity disorder. CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorders). 2019 Aug 1;18(6):496-501.
11. Ostadmohammadi V, Jamilian M, Bahmani F, Asemi Z. Vitamin D and probiotic co-supplementation affects mental health, hormonal, inflammatory and oxidative stress parameters in women with polycystic ovary syndrome. Journal of ovarian research. 2019 Dec;12:1-8.
12. Bo Y, Liu C, Ji Z, Yang R, An Q, Zhang X, You J, Duan D, Sun Y, Zhu Y, Cui H. A high whey protein, vitamin D and E supplement preserves muscle mass, strength, and quality of life in sarcopenic older adults: A double-blind randomized controlled trial. Clinical nutrition. 2019 Feb 1;38(1):159-64.
13. Di Nicola M, Dattoli L, Moccia L, Pepe M, Janiri D, Fiorillo A, Janiri L, Sani G. Serum 25-hydroxyvitamin D levels and psychological distress symptoms in patients with affective disorders during the COVID-19 pandemic. Psychoneuroendocrinology. 2020 Dec 1;122:104869.
14. Fazelian S, Amani R, Paknahad Z, Kheiri S, Khajehali L. Effect of vitamin D supplement on mood status and inflammation in vitamin D deficient type 2 diabetic women with anxiety: a randomized clinical trial. International journal of preventive medicine. 2019;10.
15. Kaviani M, Nikooyeh B, Zand H, Yaghmaei P, Neyestani TR. Effects of vitamin D supplementation on depression and some involved neurotransmitters. Journal of affective disorders. 2020 May 15;269:28-35.
16. Casati M, Boccardi V, Ferri E, Bertagnoli L, Bastiani P, Ciccone S, Mansi M, Scamosci M, Rossi PD, Mecocci P, Arosio B. Vitamin E and Alzheimer’s disease: the mediating role of cellular aging. Aging clinical and experimental research. 2020 Mar;32:459-64.
17. Hofmann AB, Schmid HM, Jabat M, Brackmann N, Noboa V, Bobes J, Garcia-Portilla MP, Seifritz E, Vetter S, Egger ST. Utility and validity of the Brief Psychiatric Rating Scale (BPRS) as a transdiagnostic scale. Psychiatry Research. 2022 Aug 1;314:114659.
18. Zhand N, Labelle A, Ghanem D, Gujral P, Han T, Huneault G, Jain GK, Robertson C. Comparison of Extrapyramidal Symptoms Among Outpatients With Schizophrenia on Long-Acting Injectable Antipsychotics. Journal of Clinical Psychopharmacology. 2022 Sep 1;42(5):475-9.
19. Jamilian H, Amirani E, Milajerdi A, Kolahdooz F, Mirzaei H, Zaroudi M, Ghaderi A, Asemi Z. The effects of vitamin D supplementation on mental health, and biomarkers of inflammation and oxidative stress in patients with psychiatric disorders: a systematic review and meta-analysis of randomized controlled trials. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2019 Aug 30;94:109651.
20. Al-Fartusie FS, Al-Bairmani HK, Al-Garawi ZS, Yousif AH. Evaluation of some trace elements and vitamins in major depressive disorder patients: a case–control study. Biological trace element research. 2019 Jun 15;189:412-9.
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Published
Dec 19, 2023
Article Details
How to Cite
Dr Muhammad Abid Prof. Dr Kausar Amir Dr Zubaida Umer Zehri. (2023). Determining the effects of Vitamin D and Vitamin E administration in Psychiatric improvement of patients with mental health problems. Journal of Population Therapeutics and Clinical Pharmacology, 30(17), 837-844. https://doi.org/10.53555/jptcp.v30i17.3774
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All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
Dr Muhammad Abid Prof. Dr Kausar Amir Dr Zubaida Umer Zehri. (2023). Determining the effects of Vitamin D and Vitamin E administration in Psychiatric improvement of patients with mental health problems. Journal of Population Therapeutics and Clinical Pharmacology, 30(17), 837-844. https://doi.org/10.53555/jptcp.v30i17.3774