ANTIOXIDANT ACTIVITY AND EVALUATION OF SEVEN MEDICINAL PLANTS FOR POTENTIAL ROLE IN MANAGING OXIDATIVE STRESS IN ANEMIA

Abstract

Anemia is a medical disorder defined by insufficient oxygen-carrying ability to meet physiological needs and is related with increased or decreased RBCs. Oxidative pressure in erythrocytes is considered as crucial mechanism of hemolysis. Disruption of membrane integrity arises from fragility, dehydration as well as extended manufacturing of reactive oxygen species. Chronic hemolysis leads to lack of hemoglobin. These metabolic changes result in the depletion of essential nutrients and micronutrients which are required for correct cellular function. In the prospective of it, the present study aimed to evaluate the antioxidant activity of seven plants Terminalia chebula, Terminalia bellirica, Syzygiumcumini, Phyllanthus emblica, Piper nigrum Linn, Amomum subulatum, and Cuminum. 2,2-diphenyl-1-picrylhydrazyl method was used for evaluation of antioxidant activity. Antioxidant activity shown 88% to 76% at concentration of 250mg, 71%- 61% at concentration of 125mg and at 48% at concentration of 65.5mg results found in my research studies. IC₅₀ value lower as the dose increase and P value ˂ 0.05 shown the significance of activity.