ROLE OF HUMAN PAPILLOMAVIRUS (HPV) IN ORAL CANCERS
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Abstract
This research explores the intricate relationship between Human Papillomavirus (HPV) and oral cancers, focusing on demographic and clinical factors. The study, conducted with a cohort of 500 patients diagnosed with oral cancers, reveals a substantial HPV prevalence of 30%. Bivariate analysis underscores a significant association between HPV status and tumor characteristics, with chi-square tests indicating a pronounced link to both tumor location (χ² = 16.78, p < 0.001) and histological type (χ² = 10.45, p = 0.005). Multivariate logistic regression, adjusting for age, gender, tumor location, and histological type, further elucidates a robust association between HPV positivity and oropharyngeal cancers (OR = 2.10, 95% CI [1.34-3.29], p = 0.001), while no significant association is observed with oral cavity cancers (OR = 1.18, 95% CI [0.74-1.89], p = 0.525). The findings carry clinical implications, suggesting tailored approaches for screening and treatment. Despite limitations in retrospective data, this study provides a foundational understanding of HPV's nuanced role in oral cancers, paving the way for prospective research and targeted interventions.
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Dr Ahmed Abu Ryash
Doctor and lecturer at Isra university, Amman / Jordan.
Dr Amir Sohail
Postgraduate resident Oral and Maxillofacial surgery Deptt Saidu College of Dentistry, Saidu Sharif, Swat.
Dr. Muhammad Umair
Assistant Professor Oral Medicine, Foundation University School of Health Sciences, Islamabad
Dr. Waqar Ali
BDS, FCPS, FFDRCSI, Assistant Professor, Oral & Maxillofacial Surgery, Akhtar Saeed Medical & Dental College, Lahore.
Dr. Syeda Sadaf Kazmi
BDS, M.Phil. (Oral Pathology), Senior demonstrator, Akhtar Saeed Medical and Dental College, Lahore.
Dr Syed Muhammad Faran Ali
Assistant Professor/Dental Surgeon, Asthetix Dental and Medical center, Office # 7 A Mezzanine floor Marine galleria Block 9 Clifton, Karachi.