EFFECT OF VITAMIN D ON LIVER ENZYMES AND NAFLD
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Keywords
NALFD, bilirubin, Vitamin D
Abstract
Background: NAFLD is one of the metabolic diseases of liver that can lead to variety of complications ranging from simple derangement in liver function to full blown cirrhosis.
Objective: To assess the effect of Vitamin D on liver function and NAFLD.
Materials & Methods: This cross-sectional study was conducted at MMC General Hospital Peshawar. Proper ethical approval was taken from the research committee of the hospital. The inclusion criteria were patient shaving fatty liver seen on imaging and graded according to criteria by a radiologist. The patients with other causes of liver derangement were excluded sampling. The sample size with non-probability convenient sampling as the technique. The patients were assessed properly and those who met the criteria were given Vitamin D for 8 weeks to assess its effect on liver function tests and grading of fatty liver Descriptive statistics were applied for checking the mean and standard deviation Paired sample test was applied to assess the effect before and after giving Vitamin D with a p value of less than 0.05 as significant.
Results: The mean age of the patients was 38 years with equal male to female ratio. The mean grade of fatty liver was 1.65 with 48.3% having mild steatosis, 38.3 moderate steatosis and 13.3 having severe steatosis while after treatment 38.3 had no steatosis, 46.7 mild steatosis and 15% had moderate steatosis. In terms of liver functions significant improvement were seen in ALT, ALP and bilirubin as reflected by p value of less than 0.05.
Conclusion: Our study concludes that role of vitamin D is instrumental in improving both the grade of fatty liver and liver function as well.
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Humera Fayaz
Department of Radiology MMC General Hospital Kabir Medical College, Peshawar – Pakistan
Amina Iftikhar
Department of Radiology MMC General Hospital Kabir Medical College, Peshawar – Pakistan
Jibran Umar Ayub Khan
Department of Medicine MMC General Hospital Kabir Medical College, Peshawar – Pakistan
Saifullah Khan Khalil
Department of Pharmacology Kabir Medical College, Peshawar – Pakistan
Sajid Razaq
Consultant Physician Dir Medical Center, Peshawar – Pakistan
Qamar Aziz
Department of Medicine MMC General Hospital Kabir Medical College, Peshawar – Pakistan