EVALUATION OF ANTIBIOTIC RESISTANCE PATTERN OF UROPATHOGENS IN PATIENTS WITH URINARY TRACT INFECTION IN A TERTIARY CARE CENTER, NORTH MAHARASHTRA
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Keywords
antibiotic resistance, Culture, UTI, uropathogens
Abstract
Background: Urinary tract infection (UTI) is one of the most common bacterial infections worldwide affects women more than men. Recently, there has been a changing trend in the pattern of antibiotic resistance amongst uropathogens. It is necessary to create an awareness of regional antibiotic resistance pattern among prescribing doctors.
Method: A retrospective hospital based study conducted at tertiary care centre north Maharashtra between October 2021 and December 2022. Patients above 18 years of age admitted to with a diagnosis of UTI included in the study. The data regarding causative uropathogens and their antibiotic susceptibility were retrieved from patient’s case record files.
Results: Culture and antibiotic sensitivity reports were analyzed. Out of 120 significant isolates, gram-negative organisms accounted for 80.5% infection. The most predominant uropathogen isolated was E.coli (72.8%) followed by Klebsiella spp (12.2%), Enterococcus (8.4%) and others. E.coli showed high resistance to ampicillin (86 %), ceftriaxone (76.5%), Co-Trimoxazole (45.5%) and fluoroquinolones (59.1% to 63%); Klebsiella spp, the second most common uropathogen showed high level of resistance with ampicillin (95%), cephalexin (91%), cefuroxime (71%), ceftriaxone (75%) and Nitrofuration (89.2%). Enterococcus were highly resistant to Tetracycline (92.9%) Ciprofloxacin (85.7%), Levofloxacin (81.8%). Where, E. coli were highly sensitive to Amikacin, Imipenem, Ertapenam. Klebsiellawere highly sensitive to Meropenem, Cefoperazone/Sulbactam, Amikacin. Enterococcuswas highly sensitive to Linezolid, Teicoplanin, Vancomycin
Conclusions: Different uropathogens and their antimicrobial resistance are a concern for future treatment options in UTI.
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Ms Durga Gajanan Mahale
Assistant Professor, Department of Pharmacology, SMBT Institute of Medical Sciences and Research Centre, Dhamangoan Nashik
Dr Rahul Chavan
MBBS MD (Pharmacology), Assistant Professor, Department of Pharmacology, SMBT Institute of Medical Sciences and Research Centre, Dhamangoan Nashik