EFFICACY OF COMBINED CRYOTHERAPY AND INTRALESIONAL MEGLUMINE ANTIMONIATE (GLUCANTIME®) VS. CRYOTHERAPY AND INTRALESIONAL MEGLUMINE ANTIMONIATE (GLUCANTIME®) ALONE FOR THE TREATMENT OF CUTANEOUS LEISHMANIASIS
Main Article Content
Keywords
Efficacy, Intralesional Glucantime and Cryotherapy, Intralesional Glucantime, Cryotherapy, cutaneous Leishmaniasis
Abstract
Introduction: Leishmaniasis is categorized into three different clinical forms that are: visceral, mucocutaneous, and cutaneous leishmaniasis (CL), of which the more frequent form is the cutaneous Leishmaniasis. There is a need for more effective and less time-consuming therapeutic methods for this condition.
Objectives: We ought to compare the efficacy of Intralesional meglumine antimoniate (Glucantime®) and cryotherapy combined whereas cryotherapy and Intralesional meglumine antimoniate (Glucantime®) alone for the treatment of cutaneous leishmaniasis.
Materials and Methods: A total of 258 (86 patients in each group) were observed. Patients were allocated in three groups that are A, B, and C. Group-A had the combination of Intralesional Glucantime and Cryotherapy fortnightly. Group-B patients received Intralesional Glucantime alone fortnightly. Group-C patients were treated with Cryotherapy alone fortnightly.
RESULTS: In Group-A the mean age was 31.37 years ± 10.99 SD. In Group-B mean age was 31 years ± 10.56 SD while in Group-C mean age was 32.50 years ± 10.50SD. In Group-A 61% of patients were male and 39% were female. In Group-B 58% of patients were male and 42% were female. In Group-C 59% of patients were male and 41% were female. Moreover, Group-A (Intralesional Glucantime and Cryotherapy) was effective in 98% patients, Group B (Intralesional Glucantime alone) was effective in 82% patients and Group C (Cryotherapy alone) was effective in 78% patients.
CONCLUSION: Our study concludes that it is more effective to use the combination of Intralesional Glucantime and Cryotherapy than either Intralesional Glucantime or Cryotherapy alone for the treatment of cutaneous Leishmaniasis.
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Arfa Ikram
Department of Dermatology, Lady Reading Hospital (LRH), Peshawar - Pakistan
Mehak Mukhtar
Emergency Satellite Hospital, Nahaqi Peshawar - Pakistan
Javeria Javed
Department of Radiology, Khyber Teaching Hospital (KTH), MTI, Peshawar - Pakistan
Amina Rahat
Department of Food & Nutrition, College of Home Economics, University of Peshawar - Pakistan
Assad Ullah
Department of Livestock Gombat Hospital, Kohat - Pakistan