STUDY ON THE FETO-MATERNAL OUTCOME IN SICKLE CELL HEMOGLOBINOPATHY AT A RURAL TERTIARY CARE CENTER IN KERALA
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Keywords
Maternal morbidity, Maternal mortality, Perinatal outcome, Perinatal mortality, Sickle cell disease, Vaso-occlusive crisis.
Abstract
Background: In India sickle cell disease is a genetic haematological condition that is common. Pregnancy outcomes can be adversely affected by sickle cell disease as it can exacerbate pregnancy difficulties. The present research was done to study the feto-maternal outcome in sickle cell hemoglobinopathy at a rural tertiary care center in Kerala.
Methods: The retrospective study was done among 28 pregnant women with sickle cell disease or trait who were seen in the department of OBG during the period of Dec 2017 – Nov 2019. Pregnancy outcomes, diagnostic morbidities, and treatments received were estimated using the cross-tabulation approach.For statistical analysis, we utilized SPSS version 25.0.
Results: Total patients suffering from sickle cell disease were 9 (32.1%) and those with sickle cell trait were 19 (67.8%). The commomcomplications seen during the pregnancy were pre-eclampsia (14.2%), postpartum eclampsia (3.5%), pre term labor (17.9%), hypertension (7.1%), IUGR (39.2%) and oligohydramnios (21.4%). Main SCD complication were Anemia (67.8%) blood transfusion (32.1%), UTI (28.5%), bone crisis (10.7%), and vaso-occlusive crisis (3.5%).Common mode of delivery was vaginal (53.5%) whereas 46.4% delivered through C-section. Perinatal outcome observed were postpartum depression and psychosis (7.12%), severe anemia and thrombocytopenia (3.5%), NICU admission (7.12%), shoulder dystocia (3.5%) and mortality (3.5%).
Conclusion: Due to obstetric and medical problems, pregnancy in individuals with sickle cell disease is linked to a higher risk of maternal morbidity and a higher risk of perinatal mortality.
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Dr. Noori Khalid
Associate Professor, Department of Obstetrics and Gynaecology, Dr. Moopen’s Medical College, Wayanad, Kerala, India.
Dr. Divya S.
Associate Professor, Department of Obstetrics and Gynaecology, Dr. Moopen’s Medical College, Wayanad, Kerala, India.
Dr. Rejeesh S. Ravi
Assistant Professor, Department of Obstetrics and Gynaecology, Malabar Medical College Hospital and Research Centre, Kozhikode, Kerala, India.
Dr. Amarpali K. S.
Associate Professor, Department of Obstetrics and Gynaecology, Dr. Moopen’s Medical College, Wayanad, Kerala, India.