Subclinical Hypothyroidism as a Risk Factor for Vascular Calcification in ESRD Patients
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Keywords
Subclinical Hypothyroidism, Vascular Calcification, ESRD
Abstract
Subclinical hypothyroidism (SCH) is defined as the absence of symptoms accompanied by an increase in thyroid-stimulating hormone (TSH) levels and normal free T3 and free T4 levels. End-stage renal disease (ESRD) is the last stage of chronic kidney disease (stage 5), characterized by an irreversible, gradual loss of renal function. Vascular calcification is the abnormal and pathological deposition of calcium salts inside vascular tissues.
Aim and objectives: To evaluate how vascular calcifications in ESRD patients are affected by SCH and study the relationship between them.
Subjects and methods: In this cross-sectional study, 100 patients were enrolled and diagnosed by ESRD patients on regular hemodialysis. All the included patients were subjected to investigate Thyroid stimulating hormone (TSH), carotid artery atherosclerosis, arterial stiffness, and vascular calcification at Aswan University Hospital, Internal Medicine Department, Faculty of Medicine.
Results: Carotid and its Correlates (age, SCH, PTH, TSH, T3, and T4) and the independent effect of SCH on carotid calcification (CAAC) differed significantly among the examined population (PTH, TSH, and SCH).
There was an insignificant difference between the studied population regarding Carotid and its Correlates (sex, DM, and PH) and the independent effect of SCH on CAAC (age, sex, T3, and T4).
Conclusion: With high sensitivity and specificity, SCH is a risk factor for vascular calcification in ESRD patients.
References
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