AN INTERVENTIONAL STUDY FOR DECREASED VITAMIN-D LEVELS AS A RISK FACTOR FOR DEVELOPING UTERINE FIBROID

Abstract

Uterine fibroids or leiomyomas are the most common tumors of females in their reproductive life, they usually represent heavy mensural bleeding, dragging abdominal pain, and pressure symptoms, there are numerous uterine fibroid risk factors, and vitamin D deficiency has a significant effect on reproductive women. In general, black women are more likely to suffer from uterine fibroid than other ethnic groups, with estimates of incidence ranging from 5.4% to 77% globally. Uterine fibroid frequency in Pakistan is believed to be around 54%. The treatment options depend upon the size, quantity, and location of the uterine fibroid. Agonists for gonadotropin-releasing hormone, selective progesterone receptor modulators, tranexamic acid, and dydrogesterone, while surgical treatment shrinks the fibroid, medical treatment only reduces the symptoms temporarily. The objective of this study was to assess the decreased Vitamin -D level as a risk factor for developing uterine fibroid. In this study, 5000 IU of vitamin D was given orally as an adjuvant therapy together with 500 mg of tranexamic acid and 10 mg of dydrogesterone. Vitamin D a, steroid hormone with a significant impact on other body areas is vitamin D, Deficiency of vitamin D may strongly correlate with the growth of leiomyomas. Our study concluded that there was evidence of a strong association between the administration of vitamin D and the reduction of the size of uterine fibroid