Sialic Acid in Diagnosis of Oral Malignancy & Premalignancy
Main Article Content
Keywords
Sialic Acid, Oral Malignancy, Premalignancy
Abstract
Oral sqamous cell carcinoma (OSCC) an epithelial origin tumor has highest prevalence rate in India and is a former disease following precancerous conditions and lesions. Aim: To compare the sialic acid levels in blood and saliva of OSCC patients with Leukoplakia and Oral Sub Mucous Fibrosis (OSMF) with normal health individual. Material and Methodology: The saliva and serum sample collected from patients and normal individual were analyzed biochemically using Yao et al method. Result: The sialic acid level hiked in OSCC and Premalignant group compared with controls. Conclusion: As the levels increased, the sialic acid can be used as diagnostic marker as well as prognostic marker post treatment. A larger study is required to be conducted for to check specificity of sialic acid as marker.
References
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14. Chinnannavar SN, Ashok L, Vidya KC, Setty SM, Narasimha GE, Garg R, et al. Evaluation of serum sialic acid, fucose levels and their ratio in oral squamous cell carcinoma. J Int Soc Prev Community Dent 2015;5:446 50.
15. Jacob TV, Ramesh M, Murali S, Ramesh K, Sanjay PR, Abraham P. A non-invasive study to estimate and compare salivary sialic acid level as tumor marker in patients with pre-cancer and oral cancer. J Can Res Ther 2016;12:634-9.
16. Achalli S, Madi M, Babu SG, Shetty SR, Kumari S, Bhat S. Sialic acid as a biomarker of oral potentially malignant disorders and oral cancer. Indian J Dent Res 2017;28:395-9.
17. Sanjay PR, Kaveri Hallikeri, Shivashankara AR Evaluation of salivary sialic acid, total protein, and totalsugar in oral cancer: A preliminary report Indian J Dent Res; 2008; 19(4):288-91.
18. Shivashankara AR, Prabhu MK. Salivary total protein, sialic acid, lipid peroxidation and glutathione in oral squamous cell carcinoma. Biomed Res 2011;22:355 9.
19. Ajay P., Ashwinirani S., Nayak A., Suragimath G., Kamala K., Sande A., Naik R. Oral cancer prevalence in Western population of Maharashtra, India, for a period of 5 years. J. Oral Res. Rev. 2018;10:11. doi: 10.4103/jorr.jorr_23_17.
2. Prashant Mathur, DNB, PhD1; Krishnan Sathishkumar, MSc1; Meesha Chaturvedi, MBBS1; Priyanka Das, B-Level1;Kondalli Lakshminarayana Sudarshan, MSc1; Stephen Santhappan, MSc, MPhil1; Vinodh Nallasamy, MSc, MPhil1; Anish John, BE1;Sandeep Narasimhan, MSc1; and Francis Selvaraj Roselind, MSc1; on behalf of ICMR-NCDIR-NCRP Investigator Group. Cancer Statistics, 2020: Report From National Cancer Registry Programme, India. JCO Global Oncol 6:1063-1075.
3. Sharma P, Saxena S, Aggarwal P. Trends in the epidemiology of oral squamous cell carcinoma in Western UP: an institutional study. Ind J Dent Res 2010; 21: 316-9.
4. Available from: http://en.wikipedia.org/wiki/Neuraminic_acid [Last accessed on 2014 Nov 10].
5. Rao VR, Krishnamoorthy L, Kumaraswamy SV, Ramaswamy G. Circulating levels in serum total sialic acid, lipid associated sialic acid and fucose in precancerous lesions and cancer of the oral cavity. Cancer Detect Prev 1998;22:237 40.
6. Joshi M, Patil R. Estimation and comparative study of serum total sialic acid levels as tumor markers in oral cancer and precancer. J Cancer Res Ther2010;6:263 6
7. Baxi BR, Patel PS, Adhvaryu SG, Dayal PK. Usefulness of serum glycoconjugates in precancerous and cancerous diseases of the oral cavity. Cancer 1991;67:135 40.
8. Taqi SA. Clinical evaluation of total and lipid bound sialic acid levels in oral precancer and oral cancer. Indian J Med Paediatr Oncol2012;33:36 41.
9. Yao K, Ubuka T, Masuoka N, Kinuta M, Ikeda T. Direct determination of bound sialic acids in sialoglycoproteins by acidic ninhydrin reaction. Anal Biochem1989;179:332‑5.
10. Bose K S, Gokhale PV, Dwivedi S, Singh M. Quantitative evaluation and correlation of serum glycoconjugates: Protein bound hexoses, sialic acid and fucose in leukoplakia, oral sub mucous fibrosis and oral cancer.J Nat Sc Biol Med 2013;4:122-125
11. Dadhich M, Prabhu V, Pai VR, D’Souza J, Harish S, Jose M, et al. Serum and salivary sialic acid as a biomarker in oral potentially malignant disorders and oral cancer. Indian J Cancer 2014;51:214 8.
12. Chittemsetti S, Manchikatla PK, Guttikonda V. Estimation of serum sialic acid in oral submucous fibrosis and oral squamous cell carcinoma. J Oral MaxillofacPathol2019;23:156.
13. Rajaram S, Danasekaran BP, Venkatachalapathy R, Prashad KV, Rajaram S. N-acetylneuraminic acid: A scrutinizing tool in oral squamous cell carcinoma diagnosis. Dent Res J 2017;14:267-71.
14. Chinnannavar SN, Ashok L, Vidya KC, Setty SM, Narasimha GE, Garg R, et al. Evaluation of serum sialic acid, fucose levels and their ratio in oral squamous cell carcinoma. J Int Soc Prev Community Dent 2015;5:446 50.
15. Jacob TV, Ramesh M, Murali S, Ramesh K, Sanjay PR, Abraham P. A non-invasive study to estimate and compare salivary sialic acid level as tumor marker in patients with pre-cancer and oral cancer. J Can Res Ther 2016;12:634-9.
16. Achalli S, Madi M, Babu SG, Shetty SR, Kumari S, Bhat S. Sialic acid as a biomarker of oral potentially malignant disorders and oral cancer. Indian J Dent Res 2017;28:395-9.
17. Sanjay PR, Kaveri Hallikeri, Shivashankara AR Evaluation of salivary sialic acid, total protein, and totalsugar in oral cancer: A preliminary report Indian J Dent Res; 2008; 19(4):288-91.
18. Shivashankara AR, Prabhu MK. Salivary total protein, sialic acid, lipid peroxidation and glutathione in oral squamous cell carcinoma. Biomed Res 2011;22:355 9.
19. Ajay P., Ashwinirani S., Nayak A., Suragimath G., Kamala K., Sande A., Naik R. Oral cancer prevalence in Western population of Maharashtra, India, for a period of 5 years. J. Oral Res. Rev. 2018;10:11. doi: 10.4103/jorr.jorr_23_17.
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Published
Nov 3, 2023
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Dr Jinal K. Chavada, Dr Viral Bhatt, Dr Mamatha M.T. , Dr Rohan Thaker, Dr Priyanshi Parikh, Dr Honey Patel. (2023). Sialic Acid in Diagnosis of Oral Malignancy & Premalignancy. Journal of Population Therapeutics and Clinical Pharmacology, 30(14), 422-429. https://mail.jptcp.com/index.php/jptcp/article/view/3316
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How to Cite
Dr Jinal K. Chavada, Dr Viral Bhatt, Dr Mamatha M.T. , Dr Rohan Thaker, Dr Priyanshi Parikh, Dr Honey Patel. (2023). Sialic Acid in Diagnosis of Oral Malignancy & Premalignancy. Journal of Population Therapeutics and Clinical Pharmacology, 30(14), 422-429. https://mail.jptcp.com/index.php/jptcp/article/view/3316