PROTECTIVE EFFECT OF DIOXOLOPYRAN DERIVATIVE ISOLATED FROM CODIUM ELONGATUM AGAINST CCL4 INDUCED HEPATOTOXICITY IN MALE WISTAR RATS.
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Keywords
Codium elongatum, Codiaceae, hepatoprotective, marine algae, dioxolopyran derivative
Abstract
Codium elongatum is a green marine algae belonging to the family Codiaceae. It is found in the intertidal zone of marine water bodies attached to the substratum. Some researchers suggest the presence of alkaloid, flavonoids, amino acids, carbohydrate and polysaccharides in C. elongatum. This study is the first report on the protective effect of water extract and isolated dioxolopyran derivative (DOPD) obtained from C .elongatum against CCl4-induced hepatotoxicity. Liver marker enzymes such as ALT, AST and total bilirubin were measured to evaluate the hepatoprotective effect. There was a notable increase in mean plasma ALT, AST and total bilirubin levels in CCl4 -intoxicated rats as compared with the control group. Histopathological damage induced by CCl4 was improved by water extract and DOPD. The results were supported by the histological study of liver excised from rats used in the experiment. Further, it can be concluded that DOPD derived from C.elongatum might have significant hepatoprotective activity.
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Himanshi
School of Pharmacy, Faculty of Health Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences, Naini, Prayagraj- 211007, Uttar Pradesh, India
Pushpraj S Gupta
School of Pharmacy, Faculty of Health Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences, Naini, Prayagraj- 211007, Uttar Pradesh, India