PREPARATION AND EVALUATION OF METOPROLOL SUCCINATE TABLET USING JACKFRUIT MUCILAGE
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Keywords
Sustained release tablet, Metoprolol succinate, Jackfruit mucilage,, Wet granulation
Abstract
The aim of the current research work was to isolate and evaluate Jackfruit mucilage to develop metoprolol succinate tablets using varying concentration of jackfruit mucilage. Tablets containing 50mg drug were prepared by wet granulation method. Compatibility study was carried out by using FTIR and confirmed that no chemical interaction took place during entrapment process. Pre-compression parameters like Bulk density, Tapped density, Carr’s index, Hausner’s ratio, and angle of repose were evaluated and post-compression parameters like Friability, Hardness, Thickness, Diameter, Weight variation, Disintegration, and Drug content estimation and Dissolution were evaluated and the results were within the acceptable official limits. In-vitro drug release was carried out by using USP dissolution rate apparatus type- II using two different dissolution media (0.1 N HCl and phosphate buffer of pH 6.8). In- vitro drug release shows, as the concentration of jackfruit mucilage increases, drug release decreases. The drug release follows first order kinetics and mechanisms was found to be super case II. The stability studies were carried out for two months. In conclusion result suggested that formulation containing jackfruit mucilage delayed the drug release could therapeutically better than conventional dosage form leading to improved efficacy and better patient compliance
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Kapil Kumar
Research Scholar, Lloyd Institute of Management and Technology, Plot No.11, Knowledge Park-II, Greater Noida, Uttar Pradesh, India-201306