COMPARISON OF CARBOXY THERAPY AND PLATELET-RICH PLASMA THERAPY IN PATIENTS WITH PERIORBITAL HYPERPIGMENTATION
Main Article Content
Keywords
Periorbital hyperpigmentation, Carboxy therapy, Platelet-Rich Plasma, Efficacy
Abstract
Objective: To compare the efficacy of carboxy therapy and Platelet-Rich Plasma therapy in patients with periorbital hyperpigmentation.
Methodology: This RCT study was conducted on 50 patients presenting with periorbital hyperpigmentation, divided in two groups equally, group A underwent PRP therapy and group B underwent carboxy therapy. Treatment response and pain was assessed between both groups.
Results: PRP therapy group showed significant efficacy in terms of response to treatment as compared to the carboxy therapy groups (P = 0.01), significant efficacy was seen in patients’ perception of treatment response in PRP therapy group (P = 0.007), In group A the patients had significantly higher pain score on VAS scale as compared to group B.
Conclusion: From our study we conclude that Platelet-Rich Plasma therapy was significantly more effective in patients with periorbital hyperpigmentation than carboxy therapy (P = 0.01)
References
2. Jage M, Mahajan S. Clinical and dermoscopic evaluation of periorbital hyperpigmentation. Indian J Dermatopathol Diagn Dermatol. 2018;5(1):42-7.
3. Nofal E, Elkot R, Nofal A, Eldesoky F, Shehata S, Sami M. Evaluation of carboxytherapy and platelet‐rich plasma in treatment of periorbital hyperpigmentation: a comparative clinical trial. J Cosmet Dermatol. 2018;17(6):1000-7.
4. Mussa, A.; Mohd Idris, R.A.; Ahmed, N.; Ahmad, S.; Murtadha, A.H.; Tengku Din, T.A.D.A.A.; Yean, C.Y.; Wan Abdul Rahman, W.F.; Mat Lazim, N.; Uskoković, V. High-dose vitamin C for cancer therapy. Pharmaceuticals 2022, 15, 711.
5. Zelenkova H. Carboxytherapy-a non-invasive method in aesthetic medicine and dermatology, and the combined usage of carboxytherapy and PRP in the periorbital area. Glob Dermatol. 2017;4(1):1-5.
6. Ellabban NF, Eyada M, Nada H, Kamel N. Efficacy and tolerability of using platelet‐rich plasma versus chemical peeling in periorbital hyperpigmentation. J Cosmet Dermatol. 2019;18(6):1680-5.
7. Kassir M, Kroumpouzos G, Puja P, Katsambas A, Galadari H, Lotti T, Abdelmaksoud A, Grabbe S, Juchems E, Goldust M. Update in minimally invasive periorbital rejuvenation with a focus on platelet‐rich plasma: A narrative review. J Cosmet Dermatol. 2020;19(5):1057-62.
8. Evans AG, Ivanic MG, Botros MA, Pope RW, Halle BR, Glassman GE, et al. Rejuvenating the periorbital area using platelet-rich plasma: a systematic review and meta-analysis. Arch Dermatol Res. 2021;13(1):1-7.
9. Merchán WH, Gómez LA, Chasoy ME, Alfonso‐Rodríguez CA, Muñoz AL. Platelet‐rich plasma, a powerful tool in dermatology. J Tissue Eng Regen Med. 2019;13(5):892-901.
10. Kelm RC, Ibrahim O. Utility of platelet-rich plasma in aesthetics. Clin Dermatol. 2022;40(1):19-28.
11. Al-Hatamleh, M.A.; Alshaer, W.; Hatmal, M.m.M.; Lambuk, L.; Ahmed, N.; Mustafa, M.Z.; Low, S.C.; Jaafar, J.; Ferji, K.; Six, J.-L. Applications of alginate-based nanomaterials in enhancing the therapeutic effects of bee products. Frontiers in Molecular Biosciences 2022, 9, 350.
12. Bukhari, B.; Naveed, M.; Makhdoom, S.I.; Jabeen, K.; Asif, M.F.; Batool, H.; Ahmed, N.; Chan, Y.Y. A comparison between organic and inorganic nanoparticles: Prime nanoparticles for tumor curation. Nano 2021, 16, 2130011.
13. Ramzan, M.; Karobari, M.I.; Heboyan, A.; Mohamed, R.N.; Mustafa, M.; Basheer, S.N.; Desai, V.; Batool, S.; Ahmed, N.; Zeshan, B. Synthesis of silver nanoparticles from extracts of wild ginger (Zingiber zerumbet) with antibacterial activity against selective multidrug resistant oral bacteria. Molecules 2022, 27, 2007.
14. Pissaridou MK, Ghanem A, Lowe N. Periorbital Discolouration Diagnosis and Treatment: Evidence-Based Review. J Cosmet Laser Ther. 2020;22(6-8):217-25.
15. Ranu H, Thng S, Goh BK, et al. Periorbital hyperpigmentation in Asians: an epidemiologic study and a proposed classification. Dermatol Surg. 2011;37(9):1297-303.
16. Sarkar R. Idiopathic cutaneous hyperchromia at the orbital region or periorbital hyperpigmentation. J Cutan Aesthet Surg. 2012;5(3):183.
17. Sarkar R, Ranjan R, Garg S, et al. Periorbital hyperpigmentation: a comprehensive review. J Clin Aesthet Dermatol. 2016;9(1):49.
18. Sheth PB, Shah HA, Dave JN. Periorbital hyperpigmentation: a study of its prevalence, common causative factors and its association with personal habits and other disorders. Indian J Dermatol. 2014;59(2):151.
19. Asilian A, Amiri A, Mokhtari F, Faghihi G, Iraji F, Mozafarpoor S. Platelet-rich plasma versus carboxytherapy for the treatment of periocular hyperpigmentation; which approach is superior? Dermatol Ther. 2021;34(4):e14980.
20. El-Tahlawi SM, Fawzy MM, El Maadawi Z, Yasen SM, Aboraia NM. Platelet-rich plasma versus carboxytherapy in the treatment of periorbital dark circles: A split-face study. J Cosmet Dermatol. 2022 Oct;21(10):4332-4338.
Article Sidebar
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Ikra Khan
FCPS, Dermatologist, Pak Emirates Military Hospital, Rawalpindi - Pakistan
Nasira Nasr
Consultant Dermatologist, Department of Dermatology, CMH Rawalakot - Pakistan
Aqsa Habib
FCPS, Resident Dermatology, Military Hospital, Rawalpindi - Pakistan
Ismat Jabin
Classified Dermatologist, Department of Dermatology, CMH Pano Aqil, Sindh - Pakistan
Samra Iram
Classified Dermatologist, Department of Dermatology, CMH Lahore, Punjab - Pakistan
Sania Iram
FCPS, Dermatologist, Pak Emirates Military Hospital, Rawalpindi - Pakistan